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Autor:
Bianca J. Kuhn, Claudia Lohrey, Felix Hoppe-Seyler, Tobias D. Strobel, Karin Hoppe-Seyler, Jeroen Krijgsveld, Julia Bulkescher, Antonia Däschle, Anja L. Herrmann
Publikováno v:
International Journal of Cancer. 149:1137-1149
Oncogenic types of human papillomaviruses (HPVs) are major human carcinogens. The viral E6/E7 oncogenes maintain the malignant growth of HPV-positive cancer cells. Targeted E6/E7 inhibition results in efficient induction of cellular senescence, which