Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Antonia A. Nikitenko"'
Autor:
Rose Barham, Thuy Hoang, Jeremy T. Starr, Jennifer A. Young, M. Megan Lemmon, Joseph Penzien, Mark J. Mitton-Fry, Thomas M. Harris, Antonia A. Nikitenko, Brian S. Gerstenberger, Sandra P. McCurdy, Veerabahu Shanmugasundaram, Lisa Mullins, Joel R. Hardink, Jeffrey M. Casavant, Eric S. Marr, Jian Lin, Seungil Han, Joel T. Arcari, John P. Mueller, Brandon P. Schuff, Mark S. Plummer, Craig J. McPherson, Michael D. Huband, Mark C. Noe, Manjinder S. Lall, Richard P. Zaniewski, Chao Li, Matthew Frank Brown, Jianmin Sun, Eric B. McElroy, Andrew P. Tomaras
Publikováno v:
Journal of Medicinal Chemistry. 56:5541-5552
Herein we describe the structure-aided design and synthesis of a series of pyridone-conjugated monobactam analogues with in vitro antibacterial activity against clinically relevant Gram-negative species including Pseudomonas aeruginosa , Klebsiella p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8694e6ad3d6cdb04a7acacaafb875122
https://doi.org/10.1021/jm400560z
https://doi.org/10.1021/jm400560z
Autor:
Zhong Li, Judy Lucas, Jonathan D. Bloom, Russell Dushin, Hao Liu, Mercy Otteng, Mark Johnson, Thomas Nittoli, Jeremy I. Levin, Andrea Olland, Jennifer M. Golas, Christoph W. Zapf, Erik Vogan, Antonia A. Nikitenko, Frank Boschelli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4602-4607
An extension of our previously reported series of macrocyclic ortho-aminobenzamide Hsp90 inhibitors is reported. Addition of a second methyl group to the tether provided analogs that show increased potency in binding as well as cell-proliferation ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292118865b349b233211d45dbcb33006
https://doi.org/10.1016/j.bmcl.2011.05.102
https://doi.org/10.1016/j.bmcl.2011.05.102
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:427-430
The knowledge of SAR in a series of biphenyl anionic RSV inhibitors has been broadened by synthesis and testing of analogs with pyrimidine linkers. Generally, pyrimidine compounds were much harder to synthesize, and their anti-RSV activity was lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d556ffc5d3906e76d85a460a73d66a0
https://doi.org/10.1016/j.bmcl.2004.10.056
https://doi.org/10.1016/j.bmcl.2004.10.056
Autor:
Irina G. Taran, Antonia A. Nikitenko, Ving J. Lee, Yuri E. Raifeld, Stanley A. Lang, Boris Arshava, Vitaly I. Shvets, Igor E. Mikerin
Publikováno v:
Tetrahedron. 54:11731-11740
The effect of A(1,3)-cis strain on the diastereoselectivity of epoxidation of (E)-and (Z)-6,6-diethoxy-3-hexen-2-ols and 4-methyl-6,6-diethoxy-3-hexen-2-ols is analyzed, with some empiric observations provided. Increased A(1,3)-cis strain results in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ad608dc9c7dd3c5c12a769ba3e6da8e
https://doi.org/10.1016/s0040-4020(98)83034-2
https://doi.org/10.1016/s0040-4020(98)83034-2
Autor:
Mark Cutler, O'hara Bryan Mark, Antonia A. Nikitenko, Stanley A. Lang, Cynthia D. Hess, Yuri Raifeld, Yakov Gluzman, Girija Krishnamurthy, Boris Feld, George A. Ellestad, Boris Mitsner, Weidong Ding, Anna Gazumyan, Joe Zaccardi, Ann Aulabaugh
Publikováno v:
Journal of Medicinal Chemistry. 41:2671-2675
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee4d27a85c0616a4cd16983fa96aa2b
https://doi.org/10.1021/jm980239e
https://doi.org/10.1021/jm980239e
Autor:
Maxim V. Jasko, Antonia A. Nikitenko, Lubov S. Viktorova, Ving J. Lee, Valery E. Zavodnik, Dmitzy G. Semizarov, B. M. Arshava, Anatoly D. Shutalev, Yuri E. Raifeld, Galina V. Gurskaya, Galina Ya. Vid, Igor E. Mikerin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:761-768
The synthesis, physicochemical properties and chain-termination properties of 3′-fluoro-3′-methyl-2′-3-dideoxythymidine is described. The synthesis was accomplished b the coupling of bis(TMS)thymine with 3-fluoro-3-methyl-2,3-dideoxy-D-erythro-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ca07be1fa8289a1104cd077271dafdb
https://doi.org/10.1016/s0960-894x(01)80197-9
https://doi.org/10.1016/s0960-894x(01)80197-9
Autor:
Ving J. Lee, Yuri E. Raifeld, Igor E. Mikerin, Lubov L. Zilberg, Galina Ya. Vid, Stanley A. Lang, Antonia A. Nikitenko, B. M. Arshava
Publikováno v:
Tetrahedron. 50:8603-8616
The enantioselective synthesis of 3-substituted and 3-methyl-3-substituted 2,3-dideoxy-D- erythro -pentoses from (3 R ,4 R )-1,1-diethoxy-3,4-epoxypentane-5-ol, (3 R ,4 R) -1,1-diethoxy-3,4-epoxy-3-methylpentane-5-ol and (2 R ,3 R )-2,3-epoxy-5-hexen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afd61b5a3188ed5bb6890bbeb2ef184b
https://doi.org/10.1016/s0040-4020(01)85335-7
https://doi.org/10.1016/s0040-4020(01)85335-7
Publikováno v:
ChemInform. 32
The design and synthesis of a new potent and selective inhibitor of the respiratory syncytial virus are described. This compound, RFI-641, emerged from analysis of the structure–activity relationship in a series of biphenyl triazine anionic compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e6f1b8067ea4367bfa977f34910e902
https://doi.org/10.1002/chin.200132240
https://doi.org/10.1002/chin.200132240
Autor:
Antonia A, Nikitenko
Publikováno v:
Current opinion in drug discoverydevelopment. 9(6)
As a result of an economically challenging environment within the pharmaceutical industry, pharmaceutical companies and their departments must increase productivity and cut costs to stay in line with the market. Discovery-led departments such as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::468081a7422899291da96df586139cc1
https://pubmed.ncbi.nlm.nih.gov/17117683
https://pubmed.ncbi.nlm.nih.gov/17117683
Autor:
Kitae Lim, John W. Ellingboe, Tarek S. Mansour, John O'Connell, Franklin J. Moy, Boris Feld, Antonia A. Nikitenko, Diane Grinberg, Geraldine Bebernitz, Matthew W. Olson, Ariamala Gopalsamy, Janis Upeslacis, Boris Mitsner
Publikováno v:
Journal of medicinal chemistry. 47(8)
Through high throughput screening of various libraries, substituted styryl naphthalene 6 was identified as an HCMV protease inhibitor. Optimization of various regions of the lead molecule using parallel synthesis resulted in 1,6-substituted naphthale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714f4da5e18c5acd3a9e9ff60525b68a
https://pubmed.ncbi.nlm.nih.gov/15055990
https://pubmed.ncbi.nlm.nih.gov/15055990