Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Antoni G. Wrobel"'
Autor:
Lena Jaki, Sebastian Weigang, Lisa Kern, Stefanie Kramme, Antoni G. Wrobel, Andrea B. Grawitz, Philipp Nawrath, Stephen R. Martin, Theo Dähne, Julius Beer, Miriam Disch, Philipp Kolb, Lisa Gutbrod, Sandra Reuter, Klaus Warnatz, Martin Schwemmle, Steven J. Gamblin, Elke Neumann-Haefelin, Daniel Schnepf, Thomas Welte, Georg Kochs, Daniela Huzly, Marcus Panning, Jonas Fuchs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Monoclonal antibodies (mAbs) directed against the spike of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are effective therapeutic options to combat infections in high-risk patients. Here, we report the adaptation of SARS-CoV-
Externí odkaz:
https://doaj.org/article/d61edc8bae2d4d3c8f29f4fd3b6b89ba
Autor:
Valeria Calvaresi, Antoni G. Wrobel, Joanna Toporowska, Dietmar Hammerschmid, Katie J. Doores, Richard T. Bradshaw, Ricardo B. Parsons, Donald J. Benton, Chloë Roustan, Eamonn Reading, Michael H. Malim, Steve J. Gamblin, Argyris Politis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
In this paper, the authors use hydrogen-deuterium exchange mass spectrometry to describe how the SARS-CoV-2 spike glycoprotein has evolved its structural dynamics features and receptor binding capability from the emergence of the original Wuhan isola
Externí odkaz:
https://doaj.org/article/97f9efb389ef48dfa07633acc7b2d899
Autor:
Antoni G. Wrobel, Donald J. Benton, Chloë Roustan, Annabel Borg, Saira Hussain, Stephen R. Martin, Peter B. Rosenthal, John J. Skehel, Steven J. Gamblin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-7 (2022)
The SARS-CoV-2 spike has been evolving in the human population. The variants of concern alpha and beta evolved to optimise spike openness and so ability to bind its receptor ACE2, the affinity towards the receptor, and stability upon receptor binding
Externí odkaz:
https://doaj.org/article/b4dd4e7327c04cb0a388bbe45794406e
Autor:
Antoni G. Wrobel, Donald J. Benton, Pengqi Xu, Lesley J. Calder, Annabel Borg, Chloë Roustan, Stephen R. Martin, Peter B. Rosenthal, John J. Skehel, Steven J. Gamblin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
It has been suggested that pangolin coronaviruses may be the origin of SARS-CoV-2. Here the authors show that the Pangolin-CoV spike is structurally closely related to the closed form of SARS-CoV-2 spike and exhibits similar binding properties to hum
Externí odkaz:
https://doaj.org/article/e6fc3e78a8f74f72b0f0a1e0880a8bb4
Autor:
Antoni G. Wrobel, Donald J. Benton, Saira Hussain, Ruth Harvey, Stephen R. Martin, Chloë Roustan, Peter B. Rosenthal, John J. Skehel, Steven J. Gamblin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-5 (2020)
Here, the authors characterise the binding and neutralisation properties of CR3022, a neutralising Ab isolated from a convalescent SARS patient, against SARS-CoV-2 spike trimers and show using Cryo-EM the disruption of SARS-CoV-2 spike by CR3022 Fab.
Externí odkaz:
https://doaj.org/article/d4d4b2a7e1194f45b301bc4c82ffd83f
We have developed broadly reactive aptamers against multiple variants by alternating the target between spike proteins from different SARS-CoV-2 variants during the selection process. In this process we have developed aptamers which can recognise all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d93675ca096c8aecbefd371354ccbdb
Autor:
Antoni G. Wrobel
Spike glycoprotein of SARS-CoV-2 mediates viral entry into host cells by facilitating virus attachment and membrane fusion. ACE2 is the main receptor of SARS-CoV-2 and its interaction with spike has shaped the virus’ emergence from an animal reserv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007ede0e28b0bd3ca1a308bba15433f6
Autor:
Edgar Gonzalez-Rodriguez, Mia Zol-Hanlon, Ganka Bineva-Todd, Andrea Marchesi, Mark Skehel, Keira E. Mahoney, Chloë Roustan, Annabel Borg, Lucia Di Vagno, Svend Kjaer, Antoni G. Wrobel, Donald J. Benton, Philipp Nawrath, Sabine L. Flitsch, Dhira Joshi, Andrés Manuel González-Ramírez, Katalin A. Wilkinson, Robert J. Wilkinson, Emma C. Wall, Ramón Hurtado-Guerrero, Stacy A. Malaker, Benjamin Schumann
Publikováno v:
Gonzalez-Rodriguez, E, Zol-Hanlon, M, Bineva-Todd, G, Marchesi, A, Skehel, M, Mahoney, K E, Roustan, C, Borg, A, Di Vagno, L, Kjær, S, Wrobel, A G, Benton, D J, Nawrath, P, Flitsch, S L, Joshi, D, González-Ramírez, A M, Wilkinson, K A, Wilkinson, R J, Wall, E C, Hurtado-Guerrero, R, Malaker, S A & Schumann, B 2023, ' O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern ', ACS Central Science, vol. 9, no. 3, pp. 393-404 . https://doi.org/10.1021/acscentsci.2c01349
The emergence of a polybasic cleavage motif for the protease furin in the SARS-CoV-2 spike protein has been established as a major factor for enhanced viral transmission in humans. The peptide region N-terminal to that motif is extensively mutated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8375bb070568530844a5ff77444ebaee
Autor:
Antoni G. Wrobel, Philipp Nawrath
Publikováno v:
Structure (London, England : 1993). 30(10)
In this issue of Structure, Lan and colleagues seek to identify regions on the ACE2 receptor and coronavirus spikes that are essential for the viral attachment. They achieve it through a detailed comparative analysis of the binding of coronaviruses N
Autor:
Nathan R. Zaccai, Zuzana Kadlecova, Veronica Kane Dickson, Kseniya Korobchevskaya, Jan Kamenicky, Oleksiy Kovtun, Perunthottathu K. Umasankar, Antoni G. Wrobel, Jonathan G. G. Kaufman, Sally R. Gray, Kun Qu, Philip R. Evans, Marco Fritzsche, Filip Sroubek, Stefan Höning, John A. G. Briggs, Bernard T. Kelly, David J. Owen, Linton M. Traub
Publikováno v:
Science Advances. 8
Clathrin-mediated endocytosis (CME) is the main mechanism by which mammalian cells control their cell surface proteome. Proper operation of the pivotal CME cargo adaptor AP2 requires membrane-localized Fer/Cip4 homology domain-only proteins (FCHO). H