Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Antoni, Olona"'
Autor:
Charlotte Hateley, Antoni Olona, Laura Halliday, Matthew L. Edin, Jeong-Hun Ko, Roberta Forlano, Ximena Terra, Fred B. Lih, Raúl Beltrán-Debón, Penelopi Manousou, Sanjay Purkayastha, Krishna Moorthy, Mark R. Thursz, Guodong Zhang, Robert D. Goldin, Darryl C. Zeldin, Enrico Petretto, Jacques Behmoaras
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105127- (2024)
Summary: Background: Obesity drives maladaptive changes in the white adipose tissue (WAT) which can progressively cause insulin resistance, type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated liver disease (MASLD). Obesity-mediated l
Externí odkaz:
https://doaj.org/article/f522db65b00f4ac6b5690aad31edc432
Autor:
Antoni Olona, Subhankar Mukhopadhyay, Charlotte Hateley, Fernando O. Martinez, Siamon Gordon, Jacques Behmoaras
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-10 (2021)
Abstract Cell membrane fusion and multinucleation in macrophages are associated with physiologic homeostasis as well as disease. Osteoclasts are multinucleated macrophages that resorb bone through increased metabolic activity resulting from cell fusi
Externí odkaz:
https://doaj.org/article/2fd5b548491e4a29a5558064d1059ef3
Autor:
Sneha Muralidharan, Federico Torta, Michelle K. Lin, Antoni Olona, Marta Bagnati, Aida Moreno-Moral, Jeong-Hun Ko, Shanshan Ji, Bo Burla, Markus R. Wenk, Hosana G. Rodrigues, Enrico Petretto, Jacques Behmoaras
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Toll-like receptor 4 (TLR4)-mediated changes in macrophages reshape intracellular lipid pools to coordinate an effective innate immune response. Although this has been previously well-studied in different model systems, it remains incompletely unders
Externí odkaz:
https://doaj.org/article/a9de5caa16a34b808e70b7f8842cd4e3
Autor:
Antoni Olona, Ximena Terra, Jeong-Hun Ko, Carme Grau-Bové, Montserrat Pinent, Anna Ardevol, Ana Garcia Diaz, Aida Moreno-Moral, Matthew Edin, David Bishop-Bailey, Darryl C. Zeldin, Timothy J. Aitman, Enrico Petretto, Mayte Blay, Jacques Behmoaras
Publikováno v:
Molecular Metabolism, Vol 11, Iss , Pp 18-32 (2018)
Objective: When molecular drivers of healthy adipogenesis are perturbed, this can cause hepatic steatosis. The role of arachidonic acid (AA) and its downstream enzymatic cascades, such as cyclooxygenase, in adipogenesis is well established. The exact
Externí odkaz:
https://doaj.org/article/d7285575e91349bf8008e12a518b25d1
Autor:
Marie Pereira, Tai-Di Chen, Norzawani Buang, Antoni Olona, Jeong-Hun Ko, Maria Prendecki, Ana S.H. Costa, Efterpi Nikitopoulou, Laura Tronci, Charles D. Pusey, H. Terence Cook, Stephen P. McAdoo, Christian Frezza, Jacques Behmoaras
Publikováno v:
Cell Reports, Vol 28, Iss 2, Pp 498-511.e5 (2019)
Summary: Iron is an essential metal that fine-tunes the innate immune response by regulating macrophage function, but an integrative view of transcriptional and metabolic responses to iron perturbation in macrophages is lacking. Here, we induced acut
Externí odkaz:
https://doaj.org/article/52934f4eeed3453cb2969714de777c3f
Autor:
Struan Bourke, Laura Urbano, Megan M. Midson, Antoni Olona, Basma Qazi-Choudhry, Maryna Panamarova, Ferran Valderrama, Nicholas J. Long, Lea-Ann Dailey, Mark Green
Publikováno v:
Bourke, S, Urbano, L, Midson, M M, Olona, A, Qazi-Chaudhry, B, Panamarova, M, Valderrama, F, Long, N J, Dailey, L-A & Green, M 2022, ' Nearly monodispersed, emission-tuneable conjugated polymer nanoparticles. ', Sensors and Diagnostics . https://doi.org/10.1039/D2SD00164K
Conjugated polymer nanoparticles have shown great promise in biological imaging due to their stable optical properties and inert composition but are usually polydispersed. By encapsulating conjugated polymer CN-PPV with a thin silica shell, it is pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a8eab05dedcddf68629b2ce3f116af
https://doi.org/10.1039/d2sd00164k
https://doi.org/10.1039/d2sd00164k
Autor:
Federico Torta, Sneha Muralidharan, Jacques Behmoaras, Antoni Olona, Markus R. Wenk, Charlotte Hateley
Publikováno v:
British Journal of Pharmacology. 178:4575-4587
Macrophage activation in response to stimulation of Toll-like receptor 4 (TLR4) provides a paradigm for investigating energy metabolism that regulates the inflammatory response. TLR4-mediated pro-inflammatory macrophage activation is characterized by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5ac4420f48ded7dc464adcc9a8a5128
https://doi.org/10.1111/bph.15642
https://doi.org/10.1111/bph.15642
Macrophages undergo profound metabolic reprogramming upon sensing infectious and sterile stimuli. This metabolic shift supports and regulates essential innate immune functions, including activation of the NLRP3 inflammasome. Within distinct metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fcdb2d5f1de3b05c91ad343e6097121
http://hdl.handle.net/10044/1/100791
http://hdl.handle.net/10044/1/100791
Autor:
Jeong-Hun Ko, Charlotte Hateley, Antoni Olona, Paras K. Anand, Marvin Johnson, Jacques Behmoaras, Jesús Gil, Ana Guerrero, David B. Thomas
Publikováno v:
British Journal of Pharmacology. 179:1874-1886
Background and purpose Cardiac glycosides (CGs) inhibit the Na+ ,K+ -ATPase and are widely prescribed medicines for chronic heart failure and cardiac arrhythmias. Recently, CGs have been described to induce inflammasome activation and pyroptosis in h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4bd9b97b78ee632e3d2994bf8a12549
https://doi.org/10.1111/bph.15423
https://doi.org/10.1111/bph.15423
Autor:
Claire Hamilton, Antoni Olona, Stuart Leishman, Kelly MacDonald-Ramsahai, Shamshad Cockcroft, Gerald Larrouy-Maumus, Paras K. Anand
Publikováno v:
ImmunoHorizons. 6(8)
Imbalance in lipid homeostasis is associated with discrepancies in immune signaling and is tightly linked to metabolic disorders. The diverse ways in which lipids impact immune signaling, however, remain ambiguous. The phospholipid phosphatidylinosit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11facab68cf62e3d72d76a7f4d06db4c
https://pubmed.ncbi.nlm.nih.gov/36038196
https://pubmed.ncbi.nlm.nih.gov/36038196