Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Antonella Roetto"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9142 (2024)
Iron is a vital element involved in a plethora of metabolic activities. Mammalian systemic iron homeostasis is mainly modulated by hepcidin, the synthesis of which is regulated by a number of proteins, including the hemochromatosis-associated protein
Externí odkaz:
https://doaj.org/article/1fb21eeb005f418c81db614abe2a6c9a
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract During physiological aging, iron accumulates in the brain with a preferential distribution in regions that are more vulnerable to age-dependent neurodegeneration such as the cerebral cortex and hippocampus. In the brain of aged wild-type mic
Externí odkaz:
https://doaj.org/article/a14ccda48eab47e8a23bfe588ee973a3
Autor:
Marie Angèle Cucci, Margherita Grattarola, Chiara Monge, Antonella Roetto, Giuseppina Barrera, Emilia Caputo, Chiara Dianzani, Stefania Pizzimenti
Publikováno v:
Antioxidants, Vol 12, Iss 6, p 1313 (2023)
The use of specific inhibitors towards mutant BRAF (BRAFi) and MEK (MEKi) in BRAF-mutated patients has significantly improved progression-free and overall survival of metastatic melanoma patients. Nevertheless, half of the patients still develop resi
Externí odkaz:
https://doaj.org/article/535882587ff54a7b88dfd08d881d032c
Autor:
Ylenia Barbanera, Francesco Arcioni, Hovirag Lancioni, Roberta La Starza, Irene Cardinali, Caterina Matteucci, Valeria Nofrini, Antonella Roetto, Antonio Piga, Paola Grammatico, Maurizio Caniglia, Cristina Mecucci, Paolo Gorello
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240632 (2020)
The hemoglobin disorders are the most common single gene disorders in the world. Previous studies have suggested that they are deeply geographically structured and a variety of genetic determinants influences different clinical phenotypes between pat
Externí odkaz:
https://doaj.org/article/7153e7955694454b9f074c5c3b33e9ac
Publikováno v:
Antioxidants, Vol 10, Iss 12, p 1864 (2021)
Iron accumulation is a key mediator of several cytotoxic mechanisms leading to the impairment of redox homeostasis and cellular death. Iron overload is often associated with haematological diseases which require regular blood transfusion/phlebotomy,
Externí odkaz:
https://doaj.org/article/2d1ddbe91257491ca12ff7878bf7e2fb
Publikováno v:
Cells, Vol 9, Iss 12, p 2591 (2020)
Cancer cells undergo considerable metabolic changes to foster uncontrolled proliferation in a hostile environment characterized by nutrient deprivation, poor vascularization and immune infiltration. While metabolic reprogramming has been recognized a
Externí odkaz:
https://doaj.org/article/233444166c744dcba478a78757580fcb
Autor:
Ulrike Baschant, Martina Rauner, Ekaterina Balaian, Heike Weidner, Antonella Roetto, Uwe Platzbecker, Lorenz C. Hofbauer
Publikováno v:
Haematologica, Vol 101, Iss 12 (2016)
Iron overload due to hemochromatosis or chronic blood transfusions has been associated with the development of osteoporosis. However, the impact of changes in iron homeostasis on osteoblast functions and the underlying mechanisms are poorly defined.
Externí odkaz:
https://doaj.org/article/a51eb38aa34b44e89d5d02bda0ba34bb
Publikováno v:
Pharmaceuticals, Vol 11, Iss 4, p 115 (2018)
Iron homeostasis is a tightly regulated process in all living organisms because this metal is essential for cellular metabolism, but could be extremely toxic when present in excess. In mammals, there is a complex pathway devoted to iron regulation, w
Externí odkaz:
https://doaj.org/article/857644d494cb47eab7ac427b7c5e22d8
Autor:
Antonella Nai, Rosa M. Pellegrino, Marco Rausa, Alessia Pagani, Martina Boero, Laura Silvestri, Giuseppe Saglio, Antonella Roetto, Clara Camaschella
Publikováno v:
Haematologica, Vol 99, Iss 6 (2014)
Transferrin receptor 2 (TFR2) is a transmembrane glycoprotein expressed in the liver and in the erythroid compartment, mutated in a form of hereditary hemochromatosis. Hepatic TFR2, together with HFE, activates the transcription of the iron-regulator
Externí odkaz:
https://doaj.org/article/680a4e14217f46e1bd31ad67d56c5443
Autor:
Maura Poli, Sara Luscieti, Valentina Gandini, Federica Maccarinelli, Dario Finazzi, Laura Silvestri, Antonella Roetto, Paolo Arosio
Publikováno v:
Haematologica, Vol 95, Iss 11 (2010)
Background Impaired regulation of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of HFE and transferrin receptor 2. However, the role of these proteins in the regulation of hepcidin expression is unclear.
Externí odkaz:
https://doaj.org/article/159b6441c5b042f780c603053f520092