Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Antonella Peduto"'
Autor:
Antonella Peduto, Mario Rocca, Cinzia De Maio, Federica Gallarotti, Giulia Pomero, Paolo Gancia
Publikováno v:
Italian Journal of Pediatrics, Vol 44, Iss 1, Pp 1-3 (2018)
Abstract Background FPIES (Food Protein Induced Eneterolitis Syndrome) is a rare non IgE- mediated food allergy, usually affecting infants and children after first months of life. Clinical presentation is heterogeneous, usually characterised by repet
Externí odkaz:
https://doaj.org/article/ab4b074577fa473a9a44b17fa307d543
Publikováno v:
Medico e Bambino pagine elettroniche. 24:114-117
Neurodevelopmental disorders (ND) have an important prevalence in children; intellectual disability in particular occurs in a heterogeneous group of genetic conditions. The evolution of molecular cytogenetic techniques and the recent advances in exom
Autor:
Mario De Rosa, Rosanna Filosa, Pieter Leyssen, Boris Pastorino, Antonella Peduto, Annalisa La Gatta, Antonia Di Mola, Leen Delang, Johan Neyts
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:6014-6025
Chikungunya virus (CHIKV), a mosquito-borne arthrogenic Alphavirus, causes an acute febrile illness in humans, that is, accompanied by severe joint pains. In many cases, the infection leads to persistent arthralgia, which may last for weeks to severa
Autor:
Federica Gallarotti, Mario Rocca, Giulia Pomero, Antonella Peduto, Paolo Gancia, Cinzia De Maio
Publikováno v:
Italian Journal of Pediatrics
Italian Journal of Pediatrics, Vol 44, Iss 1, Pp 1-3 (2018)
Italian Journal of Pediatrics, Vol 44, Iss 1, Pp 1-3 (2018)
Background FPIES (Food Protein Induced Eneterolitis Syndrome) is a rare non IgE- mediated food allergy, usually affecting infants and children after first months of life. Clinical presentation is heterogeneous, usually characterised by repetitive vom
Autor:
Mario De Rosa, Veronika Temml, Hermann Stuppner, Chiara Schiraldi, Maria Scuotto, Antonietta Rossi, Oliver Werz, Antonella Peduto, Fiorentina Roviezzo, Daniela Schuster, Bruno D'Agostino, Rosanna Filosa, Verena Krauth, Veronica Esposito
Aiming to assess the biological activities of synthetic 1,4-benzoquinones, we previously synthesized different libraries of benzoquinones with lipophilic and bulky alkyl- or aryl-substituents that inhibited 5-lipoxygenase (5-LO). The high potency of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265b17f0ab93aecb4f22b6ddbba31e69
http://hdl.handle.net/11588/652417
http://hdl.handle.net/11588/652417
Autor:
Friedrike Dehm, Dagmar Barz, Antonio Massa, Mario De Rosa, Paolo De Caprariis, Antonella Peduto, Ferdinando Bruno, Rosanna Filosa, Christina Weinigel, Verena Krauth, Oliver Werz
Publikováno v:
European Journal of Medicinal Chemistry. 81:492-498
5-Lipoxygenase (5-LO), an enzyme that catalyzes the initial steps in the biosynthesis of pro-inflammatory leukotrienes, is an attractive drug target for the pharmacotherapy of inflammatory and allergic diseases. Here, we present the design, synthesis
Autor:
Carlo Pergola, A. Di Mola, Veronika Temml, Oliver Werz, Anja M. Schaible, F Bruno, Fiorentina Roviezzo, Dagmar Barz, M. De Rosa, Andreas Koeberle, Bruno D'Agostino, Susann Luderer, Maria Antonietta De Matteis, Verena Krauth, Rosanna Filosa, Antonella Peduto, Daniela Schuster, Christina Weinigel
Publikováno v:
British Journal of Pharmacology. 171:2399-2412
Background and Purpose 1,4-Benzoquinones are well-known inhibitors of 5-lipoxygenase (5-LOX, the key enzyme in leukotriene biosynthesis), but the molecular mechanisms of 5-LOX inhibition are not completely understood. Here we investigated the molecul
Autor:
Oliver Werz, Stefan M. Noha, Antonella Peduto, Rosanna Filosa, Dagmar Barz, Daniela Schuster, Christina Weinigel, Heidi Traber, Anja M. Schaible, Veronika Temml
Publikováno v:
Biochemical Pharmacology. 86:476-486
Embelin (2,5-dihydroxy-3-undecyl-1,4-benzoquinone) possesses anti-inflammatory and anti-carcinogenic properties in vivo, and these features have been related to interference with multiple targets including XIAPs, NF kappa B, STAT-3, Akt and mTOR. How
Autor:
Maria Scuotto, Fioretina Roviezzo, Mario De Rosa, Verena Krauth, Simona Pace, Daniela Schuster, Antonella Peduto, Ulrike Garscha, Rosanna Filosa, Hermann Stuppner, Selene Collarile, Giuseppe Spaziano, Christina Weinigel, Oliver Werz, Stefanie Liening, Anja M. Schaible, Bruno D'Agostino, Markus Nett, Sebastian Schieferdecker, Veronika Temml, Silke Rummler
Publikováno v:
Biochemical pharmacology. 112
5-Lipoxygenase (5-LO) catalyzes the first two steps in leukotriene (LT) biosynthesis. Because LTs play pivotal roles in allergy and inflammation, 5-LO represents a valuable target for anti-inflammatory drugs. Here, we investigated the molecular mecha
Autor:
Marika Ambruosi, Mario De Rosa, Carmela Belardo, Selene Collarile, Veronica Esposito, Oliver Werz, Antonio Massa, Sabatino Maione, Fiederike Dehm, Rosanna Filosa, Verena Krauth, Antonella Peduto, Francesca Guida
Following the results we previously reported on a series of ethyl 2-phenylthiomethyl 5-hydroxyindole-3- carboxylate derivatives as 5-lipoxygenase (5-LOX) inhibitors, in order to obtain a more selective compound with respect to the previous generation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfdc7ffeabb03891ba546287068c7379
http://hdl.handle.net/11386/4670343
http://hdl.handle.net/11386/4670343