Splicing factors Sf3A2 and Prp31 have direct roles in mitotic chromosome segregation

Autor: Claudia Pellacani, Elisabetta Bucciarelli, Fioranna Renda, Daniel Hayward, Antonella Palena, Jack Chen, Silvia Bonaccorsi, James G Wakefield, Maurizio Gatti, Maria Patrizia Somma

Publikováno v: eLife, Vol 7 (2018)

Several studies have shown that RNAi-mediated depletion of splicing factors (SFs) results in mitotic abnormalities. However, it is currently unclear whether these abnormalities reflect defective splicing of specific pre-mRNAs or a direct role of the

Externí odkaz: https://doaj.org/article/9ca624ec66434052b0068316fa6df172

Splicing factors Sf3A2 and Prp31 have direct roles in mitotic chromosome segregation

Autor: Jack W. C. Chen, Claudia Pellacani, Elisabetta Bucciarelli, Maurizio Gatti, Antonella Palena, Daniel Hayward, Silvia Bonaccorsi, Fioranna Renda, James G. Wakefield, Maria Patrizia Somma

Publikováno v: eLife, Vol 7 (2018)
eLife
eLife 7 (2018). doi:10.7554/eLife.40325
info:cnr-pdr/source/autori:Pellacani, Claudia; Bucciarelli, Elisabetta; Renda, Fioranna; Hayward, Daniel; Palena, Antonella; Chen, Jack; Bonaccorsi, Silvia; Wakefield, James G.; Gatti, Maurizio; Somma, Maria Patrizia/titolo:Splicing factors Sf3A2 and Prp31 have direct roles in mitotic chromosome segregation/doi:10.7554%2FeLife.40325/rivista:eLife/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:7

Several studies have shown that RNAi-mediated depletion of splicing factors (SFs) results in mitotic abnormalities. However, it is currently unclear whether these abnormalities reflect defective splicing of specific pre-mRNAs or a direct role of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f5c078d79bcb7cabaea34b0d9f30af
https://doi.org/10.7554/elife.40325

Drosophila Dgt6 Interacts with Ndc80, Msps/XMAP215, and γ-Tubulin to Promote Kinetochore-Driven MT Formation

Autor: Valeria Naim, Maria Patrizia Somma, Elisabetta Bucciarelli, Claudia Pellacani, Antonella Palena, Maurizio Gatti

Publikováno v: Current biology 19 (2009): 1839–1845. doi:10.1016/j.cub.2009.09.043
info:cnr-pdr/source/autori:Bucciarelli, Elisabetta; Pellacani, Claudia; Naim, Valeria; Palena, Antonella; Gatti, Maurizio; Somma, Maria Patrizia/titolo:Drosophila Dgt6 Interacts with Ndc80, Msps%2FXMAP215, and ?-Tubulin to Promote Kinetochore-Driven MT Formation/doi:10.1016%2Fj.cub.2009.09.043/rivista:Current biology/anno:2009/pagina_da:1839/pagina_a:1845/intervallo_pagine:1839–1845/volume:19
Current biology 19 (2009): 1839–1845.
info:cnr-pdr/source/autori:E. Bucciarelli; C. Pellacani; V. Naim; A. Palena; M. Gatti; M.P. Somma/titolo:Drosophila Dgt6 protein interacts with Ndc80, Msps%2FXMAP215 and g-tubulin to promote kinetochore-driven MT formation/doi:/rivista:Current biology/anno:2009/pagina_da:1839/pagina_a:1845/intervallo_pagine:1839–1845/volume:19

In centrosome-containing cells, spindle assembly relies on microtubules (MTs) nucleated from both centrosomes and chromosomes [1, 2]. Recent work has suggested that additional spindle MTs can be nucleated by ?-tubulin ring complexes (?-TuRCs) that as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe780a2bb015062068368a8bec7d61a7

Molecular cloning of the breakpoints of the hereditary persistence of fetal hemoglobin type-6 (HPFH-6) deletion and sequence analysis of the novel juxtaposed region from the 3′ end of the β-globin gene cluster

Autor: Antonella Palena, Nicholas P. Anagnou, Theodoros Kosteas

Publikováno v: Human Genetics. 100:441-445

Naturally occurring deletion mutations within the human beta-globin cluster lead to specific, phenotypically discrete syndromes (i.e., delta beta-thalassemias and hereditary persistence of fetal hemoglobin, HPFH), characterized by increased productio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e7a797f535a42acb315683e98705a3
https://doi.org/10.1007/s004390050530

p53 Localization at Centrosomes during Mitosis and Postmitotic Checkpoint are ATM-Dependent and Require Serine 15 Phosphorylation

Autor: Rosamaria Mangiacasale, Antonella Palena, Patrizia Lavia, Marilena Ciciarello, A. Tritarelli, Silvia Soddu, Enrico Cundari, Elisa Oricchio

Publikováno v: Molecular biology of the cell 15 (2004): 3751–3757.
info:cnr-pdr/source/autori:Tritarelli A, Oricchio E, Ciciarello M, Mangiacasale R, Palena A, Lavia P, Soddu S, Cundari E./titolo:p53 Localization at Centrosomes during Mitosis and Postmitotic Checkpoint are ATM-Dependent and Require Serine 15 Phosphorylation./doi:/rivista:Molecular biology of the cell/anno:2004/pagina_da:3751/pagina_a:3757/intervallo_pagine:3751–3757/volume:15

We recently demonstrated that the p53 oncosuppressor associates to centrosomes in mitosis and this association is disrupted by treatments with microtubule-depolymerizing agents. Here, we show that ATM, an upstream activator of p53 after DNA damage, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dea6d326143de635cea8c2c10e64af8
https://publications.cnr.it/doc/11467