Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Antonella Lauri"'
Autor:
Giulia Fasano, Stefania Petrini, Valeria Bonavolontà, Graziamaria Paradisi, Catia Pedalino, Marco Tartaglia, Antonella Lauri
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-22 (2024)
Abstract Background RASopathies are genetic syndromes affecting development and having variable cancer predisposition. These disorders are clinically related and are caused by germline mutations affecting key players and regulators of the RAS-MAPK si
Externí odkaz:
https://doaj.org/article/7a729a03da08403eb3305e703b20dc15
Autor:
Martina Venditti, Catia Pedalino, Marion Rosello, Giulia Fasano, Malo Serafini, Céline Revenu, Filippo Del Bene, Marco Tartaglia, Antonella Lauri
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Current genetic modification and phenotyping methods in teleost fish allow detailed investigation of vertebrate mechanisms of development, modeling of specific aspects of human diseases and efficient testing of drugs at an organ/organismal l
Externí odkaz:
https://doaj.org/article/c595a8ce9c5949c2bb8dec48c02be6c1
Autor:
Giulia Fasano, Valentina Muto, Francesca Clementina Radio, Martina Venditti, Niloufar Mosaddeghzadeh, Simona Coppola, Graziamaria Paradisi, Erika Zara, Farhad Bazgir, Alban Ziegler, Giovanni Chillemi, Lucia Bertuccini, Antonella Tinari, Annalisa Vetro, Francesca Pantaleoni, Simone Pizzi, Libenzio Adrian Conti, Stefania Petrini, Alessandro Bruselles, Ingrid Guarnetti Prandi, Cecilia Mancini, Balasubramanian Chandramouli, Magalie Barth, Céline Bris, Donatella Milani, Angelo Selicorni, Marina Macchiaiolo, Michaela V. Gonfiantini, Andrea Bartuli, Riccardo Mariani, Cynthia J. Curry, Renzo Guerrini, Anne Slavotinek, Maria Iascone, Bruno Dallapiccola, Mohammad Reza Ahmadian, Antonella Lauri, Marco Tartaglia
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-29 (2022)
Disruptions to the ER-Golgi network can lead to neurodevelopmental disorders, though our understanding of these Golgipathies remains incomplete. Here Lauri, Tartaglia and colleagues show that ARF3 mutations cause a rare pediatric neurological disorde
Externí odkaz:
https://doaj.org/article/a42e4ca5b10d4b7dba9201eff5862471
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
The variety in the display of animals’ cognition, emotions, and behaviors, typical of humans, has its roots within the anterior-most part of the brain: the forebrain, giving rise to the neocortex in mammals. Our understanding of cellular and molecu
Externí odkaz:
https://doaj.org/article/75a61f18c87a4393a2a6ad5fc0114b27
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
While individually rare, disorders affecting development collectively represent a substantial clinical, psychological, and socioeconomic burden to patients, families, and society. Insights into the molecular mechanisms underlying these disorders are
Externí odkaz:
https://doaj.org/article/055c4cb9eb114a13b94aebe49f983835
Autor:
Ahne Myklatun, Antonella Lauri, Stephan H. K. Eder, Michele Cappetta, Denis Shcherbakov, Wolfgang Wurst, Michael Winklhofer, Gil G. Westmeyer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Advances in animal magnetoreception have been limited by a lack of tractable vertebrate laboratory models. Here, the authors demonstrate light-independent magnetoreception in mature zebrafish and medaka, as well as magnetosensitive locomotion in juve
Externí odkaz:
https://doaj.org/article/2a3bde88964948798cc4fa964171c7e5
Autor:
Thibaut Brunet, Antje HL Fischer, Patrick RH Steinmetz, Antonella Lauri, Paola Bertucci, Detlev Arendt
Publikováno v:
eLife, Vol 5 (2016)
The dichotomy between smooth and striated myocytes is fundamental for bilaterian musculature, but its evolutionary origin is unsolved. In particular, interrelationships of visceral smooth muscles remain unclear. Absent in fly and nematode, they have
Externí odkaz:
https://doaj.org/article/5e879dbc67314926b4872e4a0778077e
Autor:
Ahne Myklatun, Antonella Lauri, Stephan H. K. Eder, Michele Cappetta, Denis Shcherbakov, Wolfgang Wurst, Michael Winklhofer, Gil G. Westmeyer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Text for Correction
Externí odkaz:
https://doaj.org/article/421cd73d47a9496d8f542471d47c758d
Autor:
Elisabetta Flex, Shahad Albadri, Francesca Clementina Radio, Serena Cecchetti, Antonella Lauri, Manuela Priolo, Marta Kissopoulos, Giovanna Carpentieri, Giulia Fasano, Martina Venditti, Valentina Magliocca, Emanuele Bellacchio, Carrie L Welch, Paolo C Colombo, Stephanie M Kochav, Richard Chang, Rebekah Barrick, Marina Trivisano, Alessia Micalizzi, Rossella Borghi, Elena Messina, Cecilia Mancini, Simone Pizzi, Flavia De Santis, Marion Rosello, Nicola Specchio, Claudia Compagnucci, Kirsty McWalter, Wendy K Chung, Filippo Del Bene, Marco Tartaglia
Publikováno v:
Human Molecular Genetics. 32:473-488
Kinesins are motor proteins involved in microtubule (MT)-mediated intracellular transport. They contribute to key cellular processes, including intracellular trafficking, organelle dynamics and cell division. Pathogenic variants in kinesin-encoding g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce735168d1071ffa9c3db6983965726
https://doi.org/10.1093/hmg/ddac213
https://doi.org/10.1093/hmg/ddac213
Autor:
Viviana Claudia Canale, Giuseppe Torini, Maja Solman, Cristina Peggion, Martina Venditti, Antonella Lauri, Giada Cattani, Gianfranco Bocchinfuso, Chiara De Faveri, Jelmer Hoeksma, Paolo Calligari, Sara Bobone, Giulia Fasano, Marco Tartaglia, Lorenzo Stella, Alessio Bocedi, Tommaso Gandini, Giovanna Carpentieri, Fernando Formaggio, Simone Martinelli, Jeroen den Hertog, Elisabetta Flex, Andrea Quercioli, Massimo Sanchez, Valentina Tirelli, Valerio Santucci, Barbara Biondi, Luca Pannone
Publikováno v:
Journal of Medicinal Chemistry
Journal of medicinal chemistry, 64(21), 15973-15990. American Chemical Society
Journal of medicinal chemistry (2021). doi:10.1021/acs.jmedchem.1c01371
info:cnr-pdr/source/autori:Bobone, Sara; Pannone, Luca; Biondi, Barbara; Solman, Maja; Flex, Elisabetta; Canale, Viviana Claudia; Calligari, Paolo; De Faveri, Chiara; Gandini, Tommaso; Quercioli, Andrea; Torini, Giuseppe; Venditti, Martina; Lauri, Antonella; Fasano, Giulia; Hoeksma, Jelmer; Santucci, Valerio; Cattani, Giada; Bocedi, Alessio; Carpentieri, Giovanna; Tirelli, Valentina; Sanchez, Massimo; Peggion, Cristina; Formaggio, Fernando; Den Hertog, Jeroen; Martinelli, Simone; Bocchinfuso, Gianfranco; Tartaglia, Marco; Stella, Lorenzo/titolo:Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein-Protein Interactions/doi:10.1021%2Facs.jmedchem.1c01371/rivista:Journal of medicinal chemistry/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
Journal of medicinal chemistry, 64(21), 15973-15990. American Chemical Society
Journal of medicinal chemistry (2021). doi:10.1021/acs.jmedchem.1c01371
info:cnr-pdr/source/autori:Bobone, Sara; Pannone, Luca; Biondi, Barbara; Solman, Maja; Flex, Elisabetta; Canale, Viviana Claudia; Calligari, Paolo; De Faveri, Chiara; Gandini, Tommaso; Quercioli, Andrea; Torini, Giuseppe; Venditti, Martina; Lauri, Antonella; Fasano, Giulia; Hoeksma, Jelmer; Santucci, Valerio; Cattani, Giada; Bocedi, Alessio; Carpentieri, Giovanna; Tirelli, Valentina; Sanchez, Massimo; Peggion, Cristina; Formaggio, Fernando; Den Hertog, Jeroen; Martinelli, Simone; Bocchinfuso, Gianfranco; Tartaglia, Marco; Stella, Lorenzo/titolo:Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein-Protein Interactions/doi:10.1021%2Facs.jmedchem.1c01371/rivista:Journal of medicinal chemistry/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
We developed a new class of inhibitors of protein-protein interactions of the SHP2 phosphatase, which is pivotal in multiple signaling pathways and a central target in the therapy of cancer and rare diseases. Currently available SHP2 inhibitors targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8496126c4af6cc863ef8628f307fff54
https://pubmed.ncbi.nlm.nih.gov/34714648
https://pubmed.ncbi.nlm.nih.gov/34714648