Výsledky vyhledávání - "Antonella Ilenia Alfano"

Akademický článek

Rejuvenating the [1, 2, 3]-triazolo [1,5-a]quinoxalin-4(5H)-one scaffold: Synthesis and derivatization in a sustainable guise and preliminary antimicrobial evaluation

Autor: Sveva Pelliccia, Antonella Ilenia Alfano, Beatriz Ramos Gomes Da Assunção, Luigia Turco, Francesca Lembo, Vincenzo Summa, Elisabetta Buommino, Margherita Brindisi

Publikováno v: Frontiers in Chemistry, Vol 11 (2023)

The [1,2,3]-triazolo [1,5-a] quinoxalin-4(5H)-one scaffold and its analogues triazole-fused heterocyclic compounds are relevant structural templates in both natural and synthetic biologically active compounds. However, their medicinal chemistry appli

Externí odkaz: https://doaj.org/article/6bf770e98cbd4144a7b6499ba99d96e3

Zobrazit plný text záznamu

Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology

Autor: Simona Barone, Emilia Cassese, Antonella Ilenia Alfano, Margherita Brindisi, Vincenzo Summa

Publikováno v: Journal of Medicinal Chemistry. 65:3080-3097

Compelling new support has been provided for histone deacetylase isoform 6 (HDAC6) as a common thread in the generation of the dysregulated proinflammatory and fibrotic phenotype in cystic fibrosis (CF). HDAC6 also plays a crucial role in bacterial c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7202e2dc0a52611e1e645096118974
https://doi.org/10.1021/acs.jmedchem.1c02067

Zobrazit plný text záznamu

Coupling Interrupted Fischer and Multicomponent Joullié‐Ugi to Chase Chemical Diversity: from Batch to Sustainable Flow Synthesis of Peptidomimetics

Autor: Maria Grazia Ferraro, Antonella Ilenia Alfano, Angela Zampella, Heiko Lange, Elisabetta Buommino, Carlo Irace, Margherita Brindisi

Publikováno v: ChemMedChem. 16:3795-3809

The generation of peptidomimetic substructures for medicinal chemistry purposes requires effective and divergent synthetic methods. We present in this work an efficient flow process that allows quick modulation of reagents for Joullié-Ugi multicompo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811f4b06515d91fdce9be459ad68a320
https://doi.org/10.1002/cmdc.202100474

Zobrazit plný text záznamu

Amide Bonds Meet Flow Chemistry: A Journey into Methodologies and Sustainable Evolution

Autor: Heiko Lange, Margherita Brindisi, Antonella Ilenia Alfano

Publikováno v: ChemSusChem. 15

Formation of amide bonds is of immanent importance in organic and synthetic medicinal chemistry. Its presence in “traditional” small-molecule active pharmaceutical ingredients, in linear or cyclic oligo- and polypeptidic actives, including pseudo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2613f072bd6ecb928bc32ed3d60a33
https://doi.org/10.1002/cssc.202102708

Zobrazit plný text záznamu

Photocatalytic Isocyanide-Based Multicomponent Domino Cascade toward the Stereoselective Formation of Iminofurans

Autor: Antonella Ilenia Alfano, Davide Ravelli, Gian Cesare Tron, Sveva Pelliccia, Mariateresa Giustiniano, Ettore Novellino, Alberto Massarotti, Paolo Luciano

Publikováno v: The Journal of Organic Chemistry. 85:1981-1990

A visible-light-promoted three-component isocyanide-based synthesis of iminofurans is herein reported. The reaction proved to be general in scope and proceeds through a triple domino process. Control experiments with 18O-labeled water and TEMPO provi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a580759bbdfca51d19dbad39f8c5b419
https://doi.org/10.1021/acs.joc.9b02709

Zobrazit plný text záznamu

Flow synthesis approaches to privileged scaffolds - recent routes reviewed for green and sustainable aspects

Autor: Margherita Brindisi, Heiko Lange, Antonella Ilenia Alfano

Privileged scaffolds as starting points toward biologically active molecules represent a neuralgic point in drug discovery. The ability of synthetic chemists concerned with their generation should be flanked by robust technologies enabling the effici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ce41e265f62fb75b5a9541ca34cd3c
http://hdl.handle.net/10281/316864

Zobrazit plný text záznamu

Harnessing interrupted Fischer in continuous flow: sustainable synthesis of (spiro)indolenine and (spiro)indoline privileged scaffolds

Autor: Heiko Lange, Angela Zampella, Ettore Novellino, Margherita Brindisi, Antonella Ilenia Alfano

A greener and sustainable flow chemistry protocol for the synthesis of 3,3-disubstituted indolenines through interrupted Fischer indolisation reaction is described. First, two model aldehydes were reacted with phenylhydrazine in order to explore the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6fa77e7919ac054f8c68c24c915c34
http://hdl.handle.net/10281/316890

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání