Ferric reduction by a CYBDOM protein counteracts increased iron availability in root meristems induced by phosphorus deficiency

Autor: Rodolfo A. Maniero, Cristiana Picco, Anja Hartmann, Felipe Engelberger, Antonella Gradogna, Joachim Scholz-Starke, Michael Melzer, Georg Künze, Armando Carpaneto, Nicolaus von Wirén, Ricardo F. H. Giehl

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract To mobilize sparingly available phosphorus (P) in the rhizosphere, many plant species secrete malate to release P sorbed onto (hydr)oxides of aluminum and iron (Fe). In the presence of Fe, malate can provoke Fe over-accumulation in the root

Externí odkaz: https://doaj.org/article/40d1c4e9872b4f48835bb5b28de24f9d

Current Methods to Unravel the Functional Properties of Lysosomal Ion Channels and Transporters

Autor: Margherita Festa, Velia Minicozzi, Anna Boccaccio, Laura Lagostena, Antonella Gradogna, Tianwen Qi, Alex Costa, Nina Larisch, Shin Hamamoto, Emanuela Pedrazzini, Stefan Milenkovic, Joachim Scholz-Starke, Matteo Ceccarelli, Alessandro Vitale, Petra Dietrich, Nobuyuki Uozumi, Franco Gambale, Armando Carpaneto

Publikováno v: Cells, Vol 11, Iss 6, p 921 (2022)

A distinct set of channels and transporters regulates the ion fluxes across the lysosomal membrane. Malfunctioning of these transport proteins and the resulting ionic imbalance is involved in various human diseases, such as lysosomal storage disorder

Externí odkaz: https://doaj.org/article/fdbe2428eb234230ab4b6c8065d1a986

Tonoplast cytochrome b 561 is a transmembrane ascorbate‐dependent monodehydroascorbate reductase: functional characterization of electron currents in plant vacuoles

Autor: Antonella Gradogna, Laura Lagostena, Sara Beltrami, Edoardo Tosato, Cristiana Picco, Joachim Scholz‐Starke, Francesca Sparla, Paolo Trost, Armando Carpaneto

Publikováno v: New Phytologist. 238:1957-1971

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9106b5be8ec6d2b1cf8e6eeac812710f
https://doi.org/10.1111/nph.18823

The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection

Autor: Fioretta Palombi, Antonella D'Amore, Velia Minicozzi, Antonella Gradogna, Armando Carpaneto, Matteo Ceccarelli, Antonio Filippini

Publikováno v: Cells, Vol 10, Iss 1130, p 1130 (2021)
Cells 10 (2021). doi:10.3390/cells10051130
info:cnr-pdr/source/autori:D'Amore A.; Gradogna A.; Palombi F.; Minicozzi V.; Ceccarelli M.; Carpaneto A.; Filippini A./titolo:The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection/doi:10.3390%2Fcells10051130/rivista:Cells/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:10
Cells

The flavonoid naringenin (Nar), present in citrus fruits and tomatoes, has been identified as a blocker of an emerging class of human intracellular channels, namely the two-pore channel (TPC) family, whose role has been established in several disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8912d8a75dcd69da1c9eb2096b7e7f
https://www.mdpi.com/2073-4409/10/5/1130

The mechanism and energetics of a ligand-controlled hydrophobic gate in a mammalian two pore channel

Autor: Stefan Milenkovic, Antonella Gradogna, Laura Lagostena, Giovanni Serra, Igor V. Bodrenko, Armando Carpaneto, Matteo Ceccarelli, Andrea Bosin

Publikováno v: PCCP. Physical chemistry chemical physics
22 (2020): 15664–15674. doi:10.1039/d0cp00805b
info:cnr-pdr/source/autori:Milenkovic S.; Bodrenko I.V.; Lagostena L.; Gradogna A.; Serra G.; Bosin A.; Carpaneto A.; Ceccarelli M./titolo:The mechanism and energetics of a ligand-controlled hydrophobic gate in a mammalian two pore channel/doi:10.1039%2Fd0cp00805b/rivista:PCCP. Physical chemistry chemical physics (Print)/anno:2020/pagina_da:15664/pagina_a:15674/intervallo_pagine:15664–15674/volume:22

In the last decade two-pore intracellular channels (TPCs) attracted the interest of researchers, still some key questions remain open. Their importance for vacuolar (plants) and endo-lysosomal (animals) function highlights them as a very attractive s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee74dfa460de7e0a33839b89d7f97cf4
https://pubmed.ncbi.nlm.nih.gov/32618303