Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Antonella Chiapparino"'
Autor:
Davide Pradella, Gianluca Deflorian, Alex Pezzotta, Anna Di Matteo, Elisa Belloni, Daniele Campolungo, Andrea Paradisi, Mattia Bugatti, William Vermi, Matteo Campioni, Antonella Chiapparino, Luigi Scietti, Federico Forneris, Costanza Giampietro, Nina Volf, Michael Rehman, Serena Zacchigna, Maria Paola Paronetto, Anna Pistocchi, Anne Eichmann, Patrick Mehlen, Claudia Ghigna
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
UNC5B is a Netrin-1 receptor expressed in endothelial cells that in the absence of ligand induces apoptosis. Here the authors identify an UNC5B splicing isoform that is insensitive to the pro-survival ligand Netrin-1 and is required for apoptosis-dep
Externí odkaz:
https://doaj.org/article/bc552c64149c47869cf73be5501499a0
Autor:
Luigi Scietti, Elisabetta Moroni, Daiana Mattoteia, Marco Fumagalli, Matteo De Marco, Lisa Negro, Antonella Chiapparino, Stefano A. Serapian, Francesca De Giorgi, Silvia Faravelli, Giorgio Colombo, Federico Forneris
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Multifunctional human collagen lysyl hydroxylase (LH/PLOD) enzymes catalyze post-translational hydroxylation and subsequent glycosylation of collagens, enabling their maturation and supramolecular organization in the extracellular matrix (ECM). Recen
Externí odkaz:
https://doaj.org/article/b6a66bc99baa419fbaa8c133faca3ec4
Identification of Regulatory Molecular 'Hot Spots' for LH/PLOD Collagen Glycosyltransferase Activity
Autor:
Daiana Mattoteia, Antonella Chiapparino, Marco Fumagalli, Matteo De Marco, Francesca De Giorgi, Lisa Negro, Alberta Pinnola, Silvia Faravelli, Tony Roscioli, Luigi Scietti, Federico Forneris
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11213 (2023)
Hydroxylysine glycosylations are post-translational modifications (PTMs) essential for the maturation and homeostasis of fibrillar and non-fibrillar collagen molecules. The multifunctional collagen lysyl hydroxylase 3 (LH3/PLOD3) and the collagen gal
Externí odkaz:
https://doaj.org/article/3eec098393a04a05b60c11df3052dfd5
Autor:
Silvia Faravelli, Matteo Campioni, Martina Palamini, Anselmo Canciani, Antonella Chiapparino, Federico Forneris
Publikováno v:
Bio-Protocol, Vol 11, Iss 8 (2021)
Recombinant proteins are an essential milestone for a plethora of different applications ranging from pharmaceutical to clinical, and mammalian cell lines are among the currently preferred systems to obtain large amounts of proteins of interest due t
Externí odkaz:
https://doaj.org/article/5bd3c372d0324b8289f9b0feb7f992e2
Autor:
Antonella Chiapparino, Antonija Grbavac, Hendrik RA Jonker, Yvonne Hackmann, Sofia Mortensen, Ewa Zatorska, Andrea Schott, Gunter Stier, Krishna Saxena, Klemens Wild, Harald Schwalbe, Sabine Strahl, Irmgard Sinning
Publikováno v:
eLife, Vol 9 (2020)
Protein O-mannosyltransferases (PMTs) represent a conserved family of multispanning endoplasmic reticulum membrane proteins involved in glycosylation of S/T-rich protein substrates and unfolded proteins. PMTs work as dimers and contain a luminal MIR
Externí odkaz:
https://doaj.org/article/2e778ac32c68402bbee4231f98412614
Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3
Autor:
Luigi Scietti, Antonella Chiapparino, Francesca De Giorgi, Marco Fumagalli, Lela Khoriauli, Solomon Nergadze, Shibom Basu, Vincent Olieric, Lucia Cucca, Blerida Banushi, Antonella Profumo, Elena Giulotto, Paul Gissen, Federico Forneris
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Lysyl hydroxylase 3 (LH3) catalyzes collagen lysine hydroxylation and their subsequent O-linked glycosylation. Here the authors provide mechanistic insights into the lysyl hydroxylase and glycosyltransferase activities of LH3 by determining the cryst
Externí odkaz:
https://doaj.org/article/9671310693c340349b00e760061a12e1
Autor:
Francesca Angiolini, Elisa Belloni, Marco Giordano, Matteo Campioni, Federico Forneris, Maria Paola Paronetto, Michela Lupia, Chiara Brandas, Davide Pradella, Anna Di Matteo, Costanza Giampietro, Giovanna Jodice, Chiara Luise, Giovanni Bertalot, Stefano Freddi, Matteo Malinverno, Manuel Irimia, Jon D Moulton, James Summerton, Antonella Chiapparino, Carmen Ghilardi, Raffaella Giavazzi, Daniel Nyqvist, Davide Gabellini, Elisabetta Dejana, Ugo Cavallaro, Claudia Ghigna
Publikováno v:
eLife, Vol 8 (2019)
The biological players involved in angiogenesis are only partially defined. Here, we report that endothelial cells (ECs) express a novel isoform of the cell-surface adhesion molecule L1CAM, termed L1-ΔTM. The splicing factor NOVA2, which binds direc
Externí odkaz:
https://doaj.org/article/376dd173fafe4dde820cc904b3e48e1d
Autor:
Luigi Scietti, Antonella Chiapparino, Francesca De Giorgi, Marco Fumagalli, Lela Khoriauli, Solomon Nergadze, Shibom Basu, Vincent Olieric, Lucia Cucca, Blerida Banushi, Antonella Profumo, Elena Giulotto, Paul Gissen, Federico Forneris
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The previously published version of this Article contained an error in Figure 3. In panel a, the residues His667 and Asp669 were incorrectly labelled as His627 and Asp629. The error has been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/ed1007d7b881426da6f79c706cbe1737
Identification of Regulatory Molecular “Hot Spots” for LH/PLOD Collagen Glycosyltransferase Activity
Autor:
Forneris, Daiana Mattoteia, Antonella Chiapparino, Marco Fumagalli, Matteo De Marco, Francesca De Giorgi, Lisa Negro, Alberta Pinnola, Silvia Faravelli, Tony Roscioli, Luigi Scietti, Federico
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 11213
Hydroxylysine glycosylations are post-translational modifications (PTMs) essential for the maturation and homeostasis of fibrillar and non-fibrillar collagen molecules. The multifunctional collagen lysyl hydroxylase 3 (LH3/PLOD3) and the collagen gal
Autor:
Luigi, Scietti, Elisabetta, Moroni, Daiana, Mattoteia, Marco, Fumagalli, Matteo, De Marco, Lisa, Negro, Antonella, Chiapparino, Stefano A, Serapian, Francesca, De Giorgi, Silvia, Faravelli, Giorgio, Colombo, Federico, Forneris
Publikováno v:
Frontiers in molecular biosciences. 9
Multifunctional human collagen lysyl hydroxylase (LH/PLOD) enzymes catalyze post-translational hydroxylation and subsequent glycosylation of collagens, enabling their maturation and supramolecular organization in the extracellular matrix (ECM). Recen