Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Antonella, Sesta"'
Autor:
Francesca Pecori Giraldi, Antonella Sesta, Laura Tapella, Maria Francesca Cassarino, Luigi Castelli
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Retinoids play a pivotal role in adrenal development and differentiation. Recent clinical trials revealed therapeutic potential of both all-trans and 9-cis retinoic acid in patients with cortisol excess due to a pituitary ACTH-secreting aden
Externí odkaz:
https://doaj.org/article/5ef9d2bcf39a4ee0b8177dcff0ede382
Autor:
Francesca Pecori Giraldi, Maria Francesca Cassarino, Antonella Sesta, Giovanni Lasio, Marco Losa
Publikováno v:
Neuroendocrinology.
Introduction. The glucocorticoid receptor is pivotal to control corticotrophin (ACTH) secretion and its function is closely linked to the heat shock protein 90 (HSP90) chaperone complex. Impaired sensitivity to glucocorticoid feedback is a hallmark o
Autor:
Maria Francesca Cassarino, Laura Tapella, Luigi Castelli, Antonella Sesta, Francesca Pecori Giraldi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Scientific Reports
Scientific Reports
Retinoids play a pivotal role in adrenal development and differentiation. Recent clinical trials revealed therapeutic potential of both all-trans and 9-cis retinoic acid in patients with cortisol excess due to a pituitary ACTH-secreting adenoma and i
Autor:
F. Pecori Giraldi, Lucia Ghizzoni, Margherita Messina, Antonella Sesta, Silvia Einaudi, Chiara Manieri, Elisa Menegatti, Francesca Verna
Publikováno v:
Journal of Endocrinological Investigation
Purpose Genotype–phenotype correlation in congenital 21 hydroxylase deficiency is strong but by no means absolute. Indeed, clinical and hormonal features may vary among patients carrying similar CYP21A2 mutations, suggesting that modifier genes may
Autor:
Luigi Castelli, Antonella Sesta, Francesca Pecori Giraldi, Laura Tapella, Maria Francesca Cassarino
Publikováno v:
Endocrine Abstracts.
Autor:
Maria Francesca Cassarino, Marco Losa, Giovanni Lasio, M. R. Terreni, Alberto Giacinto Ambrogio, Antonella Sesta, Donatella Bardelli, Francesca Pecori Giraldi, Laura Libera
Publikováno v:
Neuroendocrinology. 110:119-129
Background: Somatic mutations in the ubiquitin-specific protease 8 (USP8) gene have recently been shown to occur in ACTH-secreting pituitary adenomas, thus calling attention to the ubiquitin system in corticotrope adenomas. Objectives: Assess the con
Autor:
Giovanni Lasio, Cassarino Maria Francesca, Laura Libera, Antonella Sesta, Marco Losa, Donatella Bardelli, Giraldi F. Pecori
Publikováno v:
Endocrine Abstracts.
Autor:
Antonella Sesta, Francesca Pecori Giraldi, Donatella Bardelli, Marco Losa, Giovanni Lasio, Laura Libera, Maria Francesca Cassarino
Publikováno v:
Journal of the Endocrine Society
Silibinin, a milk thistle extract with known hepatoprotective effects, has recently been shown to act upon tumoral corticotropes and revert the Cushingoid phenotype in an allograft mouse model (Riebold et al 2015). Silbinin is known to inhibit HSP90
Publikováno v:
Endocrine
Purpose A large number of studies has investigated proopiomelanocortin processing in anterior pituitary corticotropes but little is known on proopiomelanocortin/ACTH degradation within these cells. The ubiquitin-proteasome system is an intracellular
Autor:
Lucia Ghizzoni, Francesca Pecori Giraldi, Antonella Sesta, Silvia Einaudi, Francesca Verna, Margherita Messina, Elisa Menegatti
Publikováno v:
Journal of the Endocrine Society
Patients with congenital adrenal hyperplasia (CAH) due to 21 hydroxylase deficiency present a strong genotype-phenotype correlation but variability in clinical features among patients carrying similar CYP21A2 mutations suggests that polygenic traits