Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Antonella, Grigoletto"'
Autor:
Maria Rosaria Battista, Antonella Grigoletto, Tommaso Tedeschini, Antonella Cellucci, Fabrizio Colaceci, Ralph Laufer, Gianfranco Pasut, Annalise Di Marco
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Ciliary neurotrophic factor (CNTF) is a neurotrophic cytokine able to induce appetite reduction, weight loss and antidiabetic effects. However, its susceptibility to neutralizing anti-CNTF antibodies in patients hampered its use for treatment of huma
Externí odkaz:
https://doaj.org/article/275712289d7d46749feca52a20c48f5e
Autor:
Antonella Grigoletto, Gabriele Martinez, Daniela Gabbia, Tommaso Tedeschini, Michela Scaffidi, Sara De Martin, Gianfranco Pasut
Publikováno v:
Pharmaceutics, Vol 13, Iss 7, p 929 (2021)
Although selective tumor delivery of anticancer drugs has been sought by exploiting either passive targeting or by ligand-mediated targeting, a selective anticancer therapy remains an unmet medical need. Despite the advances which have been achieved
Externí odkaz:
https://doaj.org/article/3bdf0b18b69a4d7ca22374fce5e13484
Autor:
Danila Delfino, Giulia Mori, Claudio Rivetti, Antonella Grigoletto, Gloria Bizzotto, Cristian Cavozzi, Marco Malatesta, Davide Cavazzini, Gianfranco Pasut, Riccardo Percudani
Publikováno v:
Biomolecules, Vol 11, Iss 3, p 410 (2021)
In cystic fibrosis (CF), the accumulation of viscous lung secretions rich in DNA and actin is a major cause of chronic inflammation and recurrent infections leading to airway obstruction. Mucolytic therapy based on recombinant human DNase1 reduces CF
Externí odkaz:
https://doaj.org/article/39b5a8e8a36447d893be544b0a5632d4
Autor:
Gianfranco Pasut, Frances Beards, Francesca Greco, Abbie Dodd, Az Alddien Natfji, Antonella Grigoletto, Lewis Renshall, Lynda K. Harris, Helen M. I. Osborn, Angelos Evangelinos
Publikováno v:
Molecular Pharmaceutics. 19:345-353
Here, we evaluated the feasibility of non-prodrug PEG-drug conjugates to decrease the accumulation of drugs within the placental tissues. The results showed that PEG was biocompatible with the human placenta with no alteration of the basal rate of pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2666a0c847581476cb6e3b341d4656e7
https://doi.org/10.1021/acs.molpharmaceut.1c00498
https://doi.org/10.1021/acs.molpharmaceut.1c00498
Autor:
Marino Bellini, Katia Maso, Ilaria Marigo, Antonella Grigoletto, Hiroki Yoshioka, Vincenzo Ingangi, Kamiya Masaki, Midori Hirai, Lucia Raccagni, Akira Suzuki, Gianfranco Pasut
Publikováno v:
Journal of Controlled Release. 324:228-237
Poly(L-glutamic acid)-co-poly(ethylene glycol) block copolymers (PLE-PEG) are here investigated as polymers for conjugation to therapeutic proteins such as granulocyte colony stimulating factor (G-CSF) and human growth hormone (hGH). PLE-PEG block co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a92e016224131b8a36df32a187b5d3
https://doi.org/10.1016/j.jconrel.2020.05.015
https://doi.org/10.1016/j.jconrel.2020.05.015
Autor:
Diana Corallo, Giovanni Tafuro, Anna Maria Tolomeo, Michela Pozzobon, Anna Gallo, Giulia Veltri, Marco Agostini, Mattia Saggioro, Antonella Grigoletto, Sara Crotti, Valentina Serafin, Gabriele Martinez, Sara D'Aronco, Sanja Aveic, Gianfranco Pasut, Stefania D'Agostino, Alessandra Semenzato
Three-dimensional (3D) culture systems have progressively attracted attention given their potential to overcome limitations of classical 2D in vitro systems. Among different supports for 3D cell culture, hydrogels (HGs) offer important advantages suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395d36da9429610819dee26092adc5ec
http://hdl.handle.net/11577/3407092
http://hdl.handle.net/11577/3407092
Autor:
Isabella Monia Montagner, Debora Carpanese, Alessandro Penna, Gaia Zuccolotto, Antonella Grigoletto, Gianfranco Pasut, V Rossi, Antonio Rosato, A Dalla Pietà
Publikováno v:
Poster Presentations.
Background The use of proteins as immunogens is attractive for the development of vaccines, but requires efficient adjuvants to overcome their weak immunogenicity. Recently, we investigated the potential of the TLR2/4 agonist hyaluronan (HA) as an im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::236dee21d9759b85eed9dca6907ea901
https://doi.org/10.1136/jitc-2021-itoc8.53
https://doi.org/10.1136/jitc-2021-itoc8.53
Autor:
Maria Rosaria Battista, Antonella Grigoletto, Tommaso Tedeschini, Antonella Cellucci, Fabrizio Colaceci, Ralph Laufer, Gianfranco Pasut, Annalise Di Marco
Publikováno v:
PloS one. 17(3)
Ciliary neurotrophic factor (CNTF) is a neurotrophic cytokine able to induce appetite reduction, weight loss and antidiabetic effects. However, its susceptibility to neutralizing anti-CNTF antibodies in patients hampered its use for treatment of huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18984018e339d77e1a28aa1365875f54
https://pubmed.ncbi.nlm.nih.gov/35316287
https://pubmed.ncbi.nlm.nih.gov/35316287
Autor:
Antonella Grigoletto, Y. Matsuno, Tommaso Tedeschini, M. Salvalaio, Gianfranco Pasut, B. Campara, Marino Bellini, Akira Suzuki, Hiroki Yoshioka
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 337
Antibody-drug conjugates (ADCs) are an established therapeutic entity in which potent cytotoxic drugs are conjugated to a monoclonal antibody. In parallel with the great emphasis put on novel site-specific bioconjugation technologies, future advancem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9e48a97dbb8ef17547ec4e2a81a642
https://pubmed.ncbi.nlm.nih.gov/34329685
https://pubmed.ncbi.nlm.nih.gov/34329685
Autor:
Isabella Monia Montagner, Katia Maso, Antonella Grigoletto, Oddone Schiavon, Gianfranco Pasut, Antonio Rosato
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 142:49-60
Antibody drug conjugates (ADCs), which are obtained by coupling a potent cytotoxic agent to a monoclonal antibody (mAb), are traditionally bound in a random way to lysine or cysteine residues, with the final product’s heterogeneity having an import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e61d82c03243ba634962b9445f357b5d
https://doi.org/10.1016/j.ejpb.2019.06.012
https://doi.org/10.1016/j.ejpb.2019.06.012