CRISPR-edited human ES-derived oligodendrocyte progenitor cells improve remyelination in rodents

Autor: Laura J. Wagstaff, Nadine Bestard-Cuche, Maja Kaczmarek, Antonella Fidanza, Lorraine McNeil, Robin J. M. Franklin, Anna C. Williams

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract In Multiple Sclerosis (MS), inflammatory demyelinated lesions in the brain and spinal cord lead to neurodegeneration and progressive disability. Remyelination can restore fast saltatory conduction and neuroprotection but is inefficient in MS

Externí odkaz: https://doaj.org/article/7184d2b1e55348b98f2a48442e934e12

Proteomic analysis reveals a potential role for extracellular vesicles within the erythroblastic island niche

Autor: Telma Ventura, Antonella Fidanza, Marieangela C. Wilson, Daniel C. J. Ferguson, Phillip A. Lewis, Alisha May, Helen Taylor, Michael P. Rimmer, Christopher D. Gregory, Jan Frayne, Lesley M. Forrester

Publikováno v: Frontiers in Molecular Biosciences, Vol 11 (2024)

Introduction: Erythroblastic island (EBI) macrophages play an essential role in the production and maturation of the vast numbers of red blood cells (RBCs) that are produced throughout life. Their location within the bone marrow makes it difficult to

Externí odkaz: https://doaj.org/article/efb4c16f8d8e4e2885212d3119f67a99

Modelling the erythroblastic island niche of dyserythropoietic anaemia type IV patients using induced pluripotent stem cells

Autor: Alisha May, Telma Ventura, Antonella Fidanza, Helena Volmer, Helen Taylor, Nicola Romanò, Sunita L. D’Souza, James J. Bieker, Lesley M. Forrester

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Introduction: Congenital dyserythropoietic anaemia (CDA) type IV has been associated with an amino acid substitution, Glu325Lys (E325K), in the transcription factor KLF1. These patients present with a range of symptoms, including the persistence of n

Externí odkaz: https://doaj.org/article/c88b612d1db749ba874de06480b3d793

Genetic programming of macrophages generates an in vitro model for the human erythroid island niche

Autor: Martha Lopez-Yrigoyen, Cheng-Tao Yang, Antonella Fidanza, Luca Cassetta, A. Helen Taylor, Angela McCahill, Erica Sellink, Marieke von Lindern, Emile van den Akker, Joanne C. Mountford, Jeffrey W. Pollard, Lesley M. Forrester

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

In vitro differentiation of red blood cells (RBCs) is a desirable therapy for various disorders. Here the authors develop a culture system using stem cell-derived macrophages to show that inducible expression of a transcription factor, KLF1, enhances

Externí odkaz: https://doaj.org/article/b0cccdc9bb284487980ca46db3249dc4

Endothelial-specific Gata3 expression is required for hematopoietic stem cell generation

Autor: Nada Zaidan, Leslie Nitsche, Evangelia Diamanti, Rebecca Hannah, Antonella Fidanza, Nicola K. Wilson, Lesley M. Forrester, Berthold Göttgens, Katrin Ottersbach

Publikováno v: Zaidan, N, Nitsche, L, Diamanti, E, Hannah, R, Fidanza, A, Wilson, N K, Forrester, L M, Gottgens, B & Ottersbach, K 2022, ' Endothelial-specific Gata3 expression is required for hematopoietic stem cell generation ', Stem Cell Reports . https://doi.org/10.1016/j.stemcr.2022.06.008

To generate sufficient numbers of transplantable hematopoietic stem cells (HSCs) in vitro, a detailed understanding of how this process takes place in vivo is essential. The endothelial-to-hematopoietic transition (EHT), which culminates in the produ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa3588fa79fe12cb01d9501374a75a6
https://doi.org/10.1016/j.stemcr.2022.06.008