Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Antonella, Fidanza"'
Autor:
Laura J. Wagstaff, Nadine Bestard-Cuche, Maja Kaczmarek, Antonella Fidanza, Lorraine McNeil, Robin J. M. Franklin, Anna C. Williams
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract In Multiple Sclerosis (MS), inflammatory demyelinated lesions in the brain and spinal cord lead to neurodegeneration and progressive disability. Remyelination can restore fast saltatory conduction and neuroprotection but is inefficient in MS
Externí odkaz:
https://doaj.org/article/7184d2b1e55348b98f2a48442e934e12
Autor:
Paolo Petazzi, Francisco Gutierrez-Agüera, Heleia Roca-Ho, Julio Castaño, Clara Bueno, Niuska Alvarez, Lesley M. Forrester, Ana Sevilla, Antonella Fidanza, Pablo Menendez
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The CRISPR/Cas9 system has transformed genome editing by enabling precise modifications for diverse applications. Recent advancements, including base editing and prime editing, have expanded its utility beyond conventional gene knock-out and knock-in
Externí odkaz:
https://doaj.org/article/a5c34ff86ef84f9495ad57c6c81b86fc
Autor:
Telma Ventura, Antonella Fidanza, Marieangela C. Wilson, Daniel C. J. Ferguson, Phillip A. Lewis, Alisha May, Helen Taylor, Michael P. Rimmer, Christopher D. Gregory, Jan Frayne, Lesley M. Forrester
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Introduction: Erythroblastic island (EBI) macrophages play an essential role in the production and maturation of the vast numbers of red blood cells (RBCs) that are produced throughout life. Their location within the bone marrow makes it difficult to
Externí odkaz:
https://doaj.org/article/efb4c16f8d8e4e2885212d3119f67a99
Autor:
Xiaoyi Cheng, Radwa Barakat, Giulia Pavani, Masuma Khatun Usha, Rodolfo Calderon, Elizabeth Snella, Abigail Gorden, Yudi Zhang, Paul Gadue, Deborah L. French, Karin S. Dorman, Antonella Fidanza, Clyde A. Campbell, Raquel Espin-Palazon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Uncovering the mechanisms regulating hematopoietic specification not only would overcome current limitations related to hematopoietic stem and progenitor cell (HSPC) transplantation, but also advance cellular immunotherapies. However, genera
Externí odkaz:
https://doaj.org/article/c2136f3074024e3ca14b63136730c55e
Autor:
Alisha May, Telma Ventura, Antonella Fidanza, Helena Volmer, Helen Taylor, Nicola Romanò, Sunita L. D’Souza, James J. Bieker, Lesley M. Forrester
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: Congenital dyserythropoietic anaemia (CDA) type IV has been associated with an amino acid substitution, Glu325Lys (E325K), in the transcription factor KLF1. These patients present with a range of symptoms, including the persistence of n
Externí odkaz:
https://doaj.org/article/c88b612d1db749ba874de06480b3d793
Autor:
Paolo Petazzi, Raul Torres-Ruiz, Antonella Fidanza, Heleia Roca-Ho, Francisco Gutierrez-Agüera, Julio Castaño, Sandra Rodriguez-Perales, Rafael Díaz de la Guardia, Belén López-Millán, Anna Bigas, Lesley M. Forrester, Clara Bueno, Pablo Menéndez
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 20, Iss , Pp 196-204 (2020)
Human pluripotent stem cells (hPSCs) and mesenchymal stromal/stem cells (hMSCs) are clinically relevant sources for cellular therapies and for modeling human development and disease. Many stem cell-based applications rely on the ability to activate s
Externí odkaz:
https://doaj.org/article/f77cc3d8fc8949cb8341a5d7065e2798
Autor:
Martha Lopez-Yrigoyen, Cheng-Tao Yang, Antonella Fidanza, Luca Cassetta, A. Helen Taylor, Angela McCahill, Erica Sellink, Marieke von Lindern, Emile van den Akker, Joanne C. Mountford, Jeffrey W. Pollard, Lesley M. Forrester
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
In vitro differentiation of red blood cells (RBCs) is a desirable therapy for various disorders. Here the authors develop a culture system using stem cell-derived macrophages to show that inducible expression of a transcription factor, KLF1, enhances
Externí odkaz:
https://doaj.org/article/b0cccdc9bb284487980ca46db3249dc4
Autor:
Antonella Fidanza, Martha Lopez-Yrigoyen, Nicola Romanò, Rhiannon Jones, A. Helen Taylor, Lesley M. Forrester
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Abstract We have generated a drug-free, all-in-one dCAS9-SAM vector that can activate endogenous gene expression with the potential to modify cell fate. We demonstrate that this strategy can be used in a number of cell lines and avoids exceptionally
Externí odkaz:
https://doaj.org/article/edc72eebc6cf414da606a273513ae452
Autor:
Nada Zaidan, Leslie Nitsche, Evangelia Diamanti, Rebecca Hannah, Antonella Fidanza, Nicola K. Wilson, Lesley M. Forrester, Berthold Göttgens, Katrin Ottersbach
Publikováno v:
Zaidan, N, Nitsche, L, Diamanti, E, Hannah, R, Fidanza, A, Wilson, N K, Forrester, L M, Gottgens, B & Ottersbach, K 2022, ' Endothelial-specific Gata3 expression is required for hematopoietic stem cell generation ', Stem Cell Reports . https://doi.org/10.1016/j.stemcr.2022.06.008
To generate sufficient numbers of transplantable hematopoietic stem cells (HSCs) in vitro, a detailed understanding of how this process takes place in vivo is essential. The endothelial-to-hematopoietic transition (EHT), which culminates in the produ
Autor:
Domenico Iuso, Marta Czernik, Paola Toschi, Antonella Fidanza, Federica Zacchini, Robert Feil, Sandrine Curtet, Thierry Buchou, Hitoshi Shiota, Saadi Khochbin, Grazyna Ewa Ptak, Pasqualino Loi
Publikováno v:
Cell Reports, Vol 13, Iss 9, Pp 1765-1771 (2015)
Protamines confer a compact structure to the genome of male gametes. Here, we find that somatic cells can be remodeled by transient expression of protamine 1 (Prm1). Ectopically expressed Prm1 forms scattered foci in the nuclei of fibroblasts, which
Externí odkaz:
https://doaj.org/article/98dd4b38ec1342bf8de6bc3e55f668a3