Výsledky vyhledávání - "Anton V. Manuilov"

Attribute Analytics Performance Metrics from the MAM Consortium Interlaboratory Study

Autor: Trina Mouchahoir, John E. Schiel, Rich Rogers, Alan Heckert, Benjamin J. Place, Aaron Ammerman, Xiaoxiao Li, Tom Robinson, Brian Schmidt, Chris M. Chumsae, Xinbi Li, Anton V. Manuilov, Bo Yan, Gregory O. Staples, Da Ren, Alexander J. Veach, Dongdong Wang, Wael Yared, Zoran Sosic, Yan Wang, Li Zang, Anthony M. Leone, Peiran Liu, Richard Ludwig, Li Tao, Wei Wu, Ahmet Cansizoglu, Andrew Hanneman, Greg W. Adams, Irina Perdivara, Hunter Walker, Margo Wilson, Arnd Brandenburg, Nick DeGraan-Weber, Stefano Gotta, Joe Shambaugh, Melissa Alvarez, X. Christopher Yu, Li Cao, Chun Shao, Andrew Mahan, Hirsh Nanda, Kristen Nields, Nancy Nightlinger, Ben Niu, Jihong Wang, Wei Xu, Gabriella Leo, Nunzio Sepe, Yan-Hui Liu, Bhumit A. Patel, Douglas Richardson, Yi Wang, Daniela Tizabi, Oleg V. Borisov, Yali Lu, Ernest L. Maynard, Albrecht Gruhler, Kim F. Haselmann, Thomas N. Krogh, Carsten P. Sönksen, Simon Letarte, Sean Shen, Kristin Boggio, Keith Johnson, Wenqin Ni, Himakshi Patel, David Ripley, Jason C. Rouse, Ying Zhang, Carly Daniels, Andrew Dawdy, Olga Friese, Thomas W. Powers, Justin B. Sperry, Josh Woods, Eric Carlson, K. Ilker Sen, St John Skilton, Michelle Busch, Anders Lund, Martha Stapels, Xu Guo, Sibylle Heidelberger, Harini Kaluarachchi, Sean McCarthy, John Kim, Jing Zhen, Ying Zhou, Sarah Rogstad, Xiaoshi Wang, Jing Fang, Weibin Chen, Ying Qing Yu, John G. Hoogerheide, Rebecca Scott, Hua Yuan

Publikováno v: Journal of the American Society for Mass Spectrometry. 33:1659-1677

The multi-attribute method (MAM) was conceived as a single assay to potentially replace multiple single-attribute assays that have long been used in process development and quality control (QC) for protein therapeutics. MAM is rooted in traditional p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fbb68de4c53ee4678b9e74066d51588
https://doi.org/10.1021/jasms.2c00129

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New Peak Detection Performance Metrics from the MAM Consortium Interlaboratory Study

Autor: Irina Perdivara, Ben Niu, Kim F. Haselmann, St John Skilton, Anthony Leone, Gregory O. Staples, Carsten P. Sønksen, Helena Maria Barysz, Andrew Hanneman, Chun Shao, Rebecca Scott, Anders Lund, Carly Daniels, Michael Jahn, Da Ren, Nunzio Sepe, K. Ilker Sen, Zoran Sosic, David Ripley, Jing Zhen, Margo Wilson, Melissa Alvarez, John G Hoogerheide, Xinbi Li, Harini Kaluarachchi, Josh Woods, Wenqin Ni, Albrecht Gruhler, Keith A. Johnson, Arnd Brandenburg, Kristen Nields, Michelle Busch, Douglas D. Richardson, Yan Wang, Ahmet Cansizoglu, Xiaoxiao Li, Greg W Adams, Simon Letarte, Joe Shambaugh, Hua Yuan, Trina Mouchahoir, Tom Robinson, Xiaoshi Wang, Nancy S. Nightlinger, Alexander Julian Veach, Chris Chumsae, Eric Carlson, Dongdong Wang, Sean Shen, Jing Fang, Wei Wu, Stefano Gotta, Justin B. Sperry, Hirsh Nanda, X. Christopher Yu, Sibylle Heidelberger, Bhumit A. Patel, Jihong Wang, Sean McCarthy, Himakshi Patel, Thomas N. Krogh, Hunter Walker, Olga V. Friese, Daniela Tizabi, Yali Lu, Kristin Boggio, Ernest L. Maynard, Rich Rogers, Ying Zhou, Nick DeGraan-Weber, John E. Schiel, Weibin Chen, Jason C. Rouse, Li Tao, Thomas W. Powers, John Kim, Xu Guo, Bo Yan, Gabriella Leo, Ying Zhang, Oleg V. Borisov, Ying Qing Yu, Martha Stapels, Wael Yared, Yan-Hui Liu, Alan Heckert, Sarah Rogstad, Li Zang, Aaron Ammerman, Li Cao, Benjamin J. Place, Richard Ludwig, Anton V. Manuilov, Andrew Mahan, Andrew Dawdy, Yi Wang, Brian Schmidt, Peiran Liu

Publikováno v: Journal of the American Society for Mass Spectrometry. 32:913-928

The Multi-Attribute Method (MAM) Consortium was initially formed as a venue to harmonize best practices, share experiences, and generate innovative methodologies to facilitate widespread integration of the MAM platform, which is an emerging ultra-hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4baf4a0ab2df01bdb011465e0f168239
https://doi.org/10.1021/jasms.0c00415

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Quantitation of a recombinant monoclonal antibody in monkey serum by liquid chromatography–mass spectrometry

Autor: Chris Chumsae, Hongcheng Liu, Edit Tarcsa, Michelle L. Babineau, Anton V. Manuilov

Publikováno v: Analytical Biochemistry. 414:147-153

A method including protein A purification, limited Lys-C digestion, and mass spectrometry analysis was used in the study to quantify a recombinant monoclonal antibody in cynomolgus monkey serum. The same antibody that was isotopically labeled was use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c50c4cded35ea0160792150956801e
https://doi.org/10.1016/j.ab.2011.03.004

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Cell culture media supplementation of bioflavonoids for the targeted reduction of acidic species charge variants on recombinant therapeutic proteins

Autor: Christopher Racicot, Anton V. Manuilov, Patrick Hossler, Christopher Chumsae, Min Wang, Sean McDermott, Kofi Chemfe, Yun (\\'Frank\\') Zhang

Publikováno v: Biotechnology progress. 31(4)

Charge variants in recombinant proteins are an important series of protein modifications, whose potential role on protein stability, activity, immunogenicity, and pharmacokinetics continues to be studied. Monoclonal antibodies in particular have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973dd14844da21d92072a1203d5fc863
https://pubmed.ncbi.nlm.nih.gov/25920009

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Comparability analysis of protein therapeutics by bottom-up LC-MS with stable isotope-tagged reference standards

Autor: Czeslaw Radziejewski, David H. Lee, Anton V. Manuilov

Comparability studies lie at the heart of assessments that evaluate differences amongst manufacturing processes and stability studies of protein therapeutics. Low resolution chromatographic and electrophoretic methods facilitate quantitation, but do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988239c0a1333483d82514623dc585d1
https://europepmc.org/articles/PMC3218535/

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New photoreactive tRNA derivatives for probing the peptidyl transferase center of the ribosome

Autor: Robert A. Zimmermann, Stephen S. Hixson, Anton V. Manuilov

Three new photoreactive tRNA derivatives have been synthesized for use as probes of the peptidyl transferase center of the ribosome. In two of these derivatives, the 3' adenosine of yeast tRNA(Phe) has been replaced by either 2-azidodeoxyadenosine or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72300e134bc92c5c797b657ac41353ca
https://europepmc.org/articles/PMC1852821/

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Differential effects of replacing Escherichia coli ribosomal protein L27 with its homologue from Aquifex aeolicus

Autor: Robert A. Zimmermann, Bruce A. Maguire, Anton V. Manuilov

Publikováno v: Journal of bacteriology. 183(22)

The rpmA gene, which encodes 50S ribosomal subunit protein L27, was cloned from the extreme thermophile Aquifex aeolicus , and the protein was overexpressed and purified. Comparison of the A . aeolicus protein with its homologue from Escherichia coli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8857c467a051aece0adc5524264d4e
https://pubmed.ncbi.nlm.nih.gov/11673426

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Akademický článek

Comparability analysis of protein therapeutics by bottom-up LC-MS with stable isotope-tagged reference standards.

Publikováno v: mAbs; 2011, Vol. 3 Issue 4, p387-395, 9p

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