Výsledky vyhledávání - "Anton Preisinger"

Akademický článek

Local, Controlled Release In Vivo of Vascular Endothelial Growth Factor Within a Subcutaneous Scaffolded Islet Implant Reduces Early Islet Necrosis and Improves Performance of the Graft

Autor: John A. Gebe, Anton Preisinger, Michel D. Gooden, Leonard A. D’Amico, Robert B. Vernon

Publikováno v: Cell Transplantation, Vol 27 (2018)

Islet transplantation remains the only alternative to daily insulin therapy for control of type 1 diabetes (T1D) in humans. To avoid the drawbacks of intrahepatic islet transplantation, we are developing a scaffolded islet implant to transplant islet

Externí odkaz: https://doaj.org/article/13f7976aa70a467299a41920b947c0c8

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Akademický článek

IL-10 Induction from Implants Delivering Pancreatic Islets and Hyaluronan

Autor: Paul L. Bollyky, Robert B. Vernon, Ben A. Falk, Anton Preisinger, Michel D. Gooden, Gerald T. Nepom, John A. Gebe

Publikováno v: Journal of Diabetes Research, Vol 2013 (2013)

Local induction of pro-tolerogenic cytokines, such as IL-10, is an appealing strategy to help facilitate transplantation of islets and other tissues. Here, we describe a pair of implantable devices that capitalize on our recent finding that hyalurona

Externí odkaz: https://doaj.org/article/200cbd63fa2148beb9dbb942ded0aaa8

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Akademický článek

Reversal of Diabetes in Mice with a Bioengineered Islet Implant Incorporating a Type I Collagen Hydrogel and Sustained Release of Vascular Endothelial Growth Factor

Autor: Robert B. Vernon, Anton Preisinger, Michel D. Gooden, Leonard A. D'amico, Betty B. Yue, Paul L. Bollyky, Christian S. Kuhr, Thomas R. Hefty, Gerald T. Nepom, John A. Gebe Ph.D.

Publikováno v: Cell Transplantation, Vol 21 (2012)

We have developed a bioengineered implant (BI) to evaluate strategies to promote graft survival and function in models of islet transplantation in mice. The BI, sized for implantation within a fold of intestinal mesentery, consists of a disk-shaped,

Externí odkaz: https://doaj.org/article/5ba1b75c0ae4498695e690614b0b2276

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Controlled release of monoclonal antibodies from poly-l-lysine-coated alginate spheres within a scaffolded implant mitigates autoimmune responses to transplanted islets and limits systemic antibody toxicity

Autor: John A. Gebe, Anton Preisinger, Michel D. Gooden, Robert B. Vernon

Publikováno v: Materials Science and Engineering: C. 93:390-398

Immunomodulatory monoclonal antibodies (IM-mAbs) are a cornerstone of modern immunotherapy; however, when administered systemically (i.e., via injection), these agents can generate a variety of negative side effects. For many diseases, systemic deliv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fa138f243a01e32454b63beb4aabfa
https://doi.org/10.1016/j.msec.2018.07.056

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Local, Controlled Release In Vivo of Vascular Endothelial Growth Factor Within a Subcutaneous Scaffolded Islet Implant Reduces Early Islet Necrosis and Improves Performance of the Graft

Autor: Anton Preisinger, Leonard A D'Amico, John A. Gebe, Robert B. Vernon, Michel D. Gooden

Publikováno v: Cell Transplantation, Vol 27 (2018)
Cell Transplantation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6b9e5f7cac63a3fd35ca8f77cf4aa8
https://doi.org/10.1177/0963689718754562

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Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis

Autor: Vivekananda Gupta Sunkari, Anton Preisinger, John A. Gebe, Paul L. Bollyky, Robert B. Vernon, Hedwich F. Kuipers, Pamela Y. Johnson, Daniel J. Campbell, Marika Bogdani, Ben A. Falk, Thomas N. Wight, Gernot Kaber, Michel D. Gooden, Nadine Nagy, Anthony J. Day

Publikováno v: Journal of Clinical Investigation. 125:3928-3940

We recently reported that abundant deposits of the extracellular matrix polysaccharide hyaluronan (HA) are characteristic of autoimmune insulitis in patients with type 1 diabetes (T1D), but the relevance of these deposits to disease was unclear. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24cc6fe56efc88c87330f08c099c9f19
https://doi.org/10.1172/jci79271

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IL-10 Induction from Implants Delivering Pancreatic Islets and Hyaluronan

Autor: John A. Gebe, Gerald T. Nepom, Michel D. Gooden, Ben A. Falk, Paul L. Bollyky, Robert B. Vernon, Anton Preisinger

Publikováno v: Journal of Diabetes Research
Journal of Diabetes Research, Vol 2013 (2013)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7438ab977c62a816486193f2edc41de6
https://doi.org/10.1155/2013/342479

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Reversal of Diabetes in Mice with a Bioengineered Islet Implant Incorporating a Type I Collagen Hydrogel and Sustained Release of Vascular Endothelial Growth Factor

Autor: Leonard A. D'Amico, Betty B. Yue, Thomas R. Hefty, Gerald T. Nepom, Anton Preisinger, Michel D. Gooden, Robert B. Vernon, Christian S. Kuhr, Paul L. Bollyky, John A. Gebe

Publikováno v: Cell Transplantation, Vol 21 (2012)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d508aaa847b5825ff3a2f6f1385eb42c
https://doi.org/10.3727/096368912x636786

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ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors

Autor: S. Alice Long, Paul L. Bollyky, Gregory E. Holt, Anton Preisinger, Ben A. Falk, Brandon Teng, Nathan Standifer, Cindy Fang Xie, Gerald T. Nepom, John A. Gebe, Kathleen R. Braun, Robert B. Vernon, Peter L. Samuels, Rebecca P. Wu, James D. Lord, Thomas N. Wight

Publikováno v: Proceedings of the National Academy of Sciences. 108:7938-7943

We describe a role for ECM as a biosensor for inflammatory microenvironments that plays a critical role in peripheral immune tolerance. We show that hyaluronan (HA) promotes induction of Foxp3- IL-10–producing regulatory T cells (TR1) from conventi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20da92284fef53c7c711f25eb44927aa
https://doi.org/10.1073/pnas.1017360108

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CD44 Costimulation Promotes FoxP3+ Regulatory T Cell Persistence and Function via Production of IL-2, IL-10, and TGF-β

Autor: Paul L. Bollyky, Jane H. Buckner, Ben A. Falk, Stephen P. Evanko, Thomas N. Wight, Kathy R. Braun, S. Alice Long, Anton Preisinger, Rebecca P. Wu, Gerald T. Nepom

Publikováno v: The Journal of Immunology. 183:2232-2241

Work by our group and others has demonstrated a role for the extracellular matrix receptor CD44 and its ligand hyaluronan in CD4+CD25+ regulatory T cell (Treg) function. Herein, we explore the mechanistic basis for this observation. Using mouse FoxP3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0aa4397e6853aa5775a2afdebb78ed7
https://doi.org/10.4049/jimmunol.0900191

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