Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Anton Pekcec"'
Autor:
Martin M. Jendryka, Uwe Lewin, Bastiaan van der Veen, Sampath K. T. Kapanaiah, Vivien Prex, Daniel Strahnen, Thomas Akam, Birgit Liss, Anton Pekcec, Wiebke Nissen, Dennis Kätzel
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The anterior cingulate cortex (ACC) has been implicated in attention deficit hyperactivity disorder (ADHD). More specifically, an appropriate balance of excitatory and inhibitory activity in the ACC may be critical for the control of impulsi
Externí odkaz:
https://doaj.org/article/e03ece03855f4b4da4d865aaec55d90b
Autor:
Malarvizhi Gurusamy, Saeed Nasseri, Dileep Reddy Rampa, Huiying Feng, Dongwon Lee, Anton Pekcec, Henri Doods, Dongmei Wu
Publikováno v:
European Journal of Medical Research, Vol 28, Iss 1, Pp 1-13 (2023)
Abstract Background Airway remodeling is an important pathological feature of chronic airway diseases, which leads to a progressive decline in lung function. The present study examined the anti-remodeling and anti- inflammatory effect of BIBF1000, a
Externí odkaz:
https://doaj.org/article/266238147ea6421c9ed6e0effd4f7cd5
Autor:
Dileep Reddy Rampa, Huiying Feng, Sivakumar Allur-Subramaniyan, Kwanseob Shim, Anton Pekcec, Dongwon Lee, Henri Doods, Dongmei Wu
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Background and aims Kinin B1 receptors (B1Rs) are implicated in the pathogenesis of fibrosis. This study examined the anti-fibrotic effects of B1R blockade with BI 113823 in two established mouse models of hepatic fibrosis induced by intrape
Externí odkaz:
https://doaj.org/article/ed741575167b41e39ebe8f2cd2f06414
Autor:
Dileep Reddy Rampa, Priya Murugesan, Honglu Chao, Huiying Feng, Wenxin Dai, Dongwon Lee, Anton Pekcec, Henri Doods, Dongmei Wu
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-16 (2021)
Abstract Background This study examined whether BI113823, a novel selective kinin B1 receptor antagonist can reverse established pulmonary arterial hypertension (PAH), prevent right heart failure and death, which is critical for clinical translation.
Externí odkaz:
https://doaj.org/article/6486253743b248c48dd7c38ef7667413
Autor:
Malarvizhi Gurusamy, Saeed Nasseri, Dileep Reddy Rampa, Huiying Feng, Dongwon Lee, Anton Pekcec, Henri Doods, Dongmei Wu
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-11 (2021)
Abstract Background To examine the effects of BI 1029539 (GS-248), a novel selective human microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor, in experimental models of acute lung injury (ALI) and sepsis in transgenic mice constitutively expre
Externí odkaz:
https://doaj.org/article/35632fa1b861488a9bc88054c6b87659
Autor:
Bastiaan van der Veen, Sampath K. T. Kapanaiah, Kasyoka Kilonzo, Peter Steele-Perkins, Martin M. Jendryka, Stefanie Schulz, Bosiljka Tasic, Zizhen Yao, Hongkui Zeng, Thomas Akam, Janet R. Nicholson, Birgit Liss, Wiebke Nissen, Anton Pekcec, Dennis Kätzel
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
In order to identify receptors that may serve as therapeutic targets in the treatment of impulse control disorders, van der Veen et al developed a systematic target discovery approach combining behavioural chemogenetics and gene expression analysis.
Externí odkaz:
https://doaj.org/article/cd48bdbae6944aca8dc5ad44ab6da068
Autor:
Milena J. Tosiek, Kerstin Groesser, Anton Pekcec, Monika Zwirek, Gavuthami Murugesan, Eric Borges
Publikováno v:
Journal of Immunology Research, Vol 2022 (2022)
C-Type lectin receptor 5A (CLEC5A) is a spleen tyrosine kinase- (Syk-) coupled pattern recognition receptor expressed on myeloid cells and involved in the innate immune response to viral and bacterial infections. Activation of the CLEC5A receptor wit
Externí odkaz:
https://doaj.org/article/f951283ca4f54a589105c9465dface2f
Autor:
Lukasz Piszczek, Andreea Constantinescu, Dominic Kargl, Jelena Lazovic, Anton Pekcec, Janet R Nicholson, Wulf Haubensak
Publikováno v:
eLife, Vol 11 (2022)
Behavioral strategies require gating of premature responses to optimize outcomes. Several brain areas control impulsive actions, but the neuronal basis of natural variation in impulsivity between individuals remains largely unknown. Here, by combinin
Externí odkaz:
https://doaj.org/article/6fd0b3a2a2f346bfa90ac9fa3a32584a
Autor:
Rebecca Ebenhoch, Abbas Akhdar, Marc R. Reboll, Mortimer Korf-Klingebiel, Priyanka Gupta, Julie Armstrong, Yining Huang, Lee Frego, Irina Rybina, John Miglietta, Anton Pekcec, Kai C. Wollert, Herbert Nar
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Myeloid-derived growth factor (MYDGF) is an angiogenic growth factor with therapeutic potential for ischemic tissue repair and the receptor is still unknown. Here the authors present the crystal structure of human MYDGF and identify its functional ep
Externí odkaz:
https://doaj.org/article/7aa1821abf454c21a63dba52daa89da7
Impact of the PSA-NCAM system on pathophysiology in a chronic rodent model of temporal lobe epilepsy
Publikováno v:
Neurobiology of Disease, Vol 27, Iss 1, Pp 54-66 (2007)
Polysialylation is a posttranslational modification of the neural cell adhesion molecule (NCAM). In the adult brain, polysialylated NCAM (PSA-NCAM) is restricted to regions of neurogenesis and neuroplasticity, where PSA promotes plastic changes. Beca
Externí odkaz:
https://doaj.org/article/c21ad68649a24effbe3109dabb516865