Zobrazeno 1 - 10
of 329
pro vyhledávání: '"Anton M. Jetten"'
Autor:
Chao Zhang, Michael Rehman, Xin Tian, Steven Lim Cho Pei, Jianlei Gu, Thomas A. Bell, Ke Dong, Ming Shen Tham, Yiqiang Cai, Zemeng Wei, Felix Behrens, Anton M. Jetten, Hongyu Zhao, Monkol Lek, Stefan Somlo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Mouse models of autosomal dominant polycystic kidney disease (ADPKD) show that intact primary cilia are required for cyst growth following the inactivation of polycystin-1. The signaling pathways underlying this process, termed cilia-depende
Externí odkaz:
https://doaj.org/article/be382d3d7234491f9e63a463c7ab57e7
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Background Loss of the transcription factor GLI-Similar 3 (GLIS3) function causes congenital hypothyroidism (CH) in both humans and mice due to decreased expression of several thyroid hormone (TH) biosynthetic genes in thyroid follicular cel
Externí odkaz:
https://doaj.org/article/00d726bfdce14c65b8344d1a622b9f7c
Autor:
Zorica Janjetovic, Shariq Qayyum, Sivani B. Reddy, Ewa Podgorska, S. Gates Scott, Justyna Szpotan, Alisa A. Mobley, Wei Li, Vijay K. Boda, Senthilkumar Ravichandran, Robert C. Tuckey, Anton M. Jetten, Andrzej T. Slominski
Publikováno v:
Cells, Vol 13, Iss 3, p 239 (2024)
We investigated multiple signaling pathways activated by CYP11A1-derived vitamin D3 hydroxymetabolites in human skin fibroblasts by assessing the actions of these molecules on their cognate receptors and by investigating the role of CYP27B1 in their
Externí odkaz:
https://doaj.org/article/49e273a96d6b44959945a696dfc09806
Autor:
Andrzej T. Slominski, Tae-Kang Kim, Radomir M. Slominski, Yuwei Song, Shariq Qayyum, Wojciech Placha, Zorica Janjetovic, Konrad Kleszczyński, Venkatram Atigadda, Yuhua Song, Chander Raman, Cornelis J. Elferink, Judith Varady Hobrath, Anton M. Jetten, Russel J. Reiter
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15496 (2023)
Melatonin is widely present in Nature. It has pleiotropic activities, in part mediated by interactions with high-affinity G-protein-coupled melatonin type 1 and 2 (MT1 and MT2) receptors or under extreme conditions, e.g., ischemia/reperfusion. In pha
Externí odkaz:
https://doaj.org/article/aedfc88a4e004f4881a92b6461ce04d9
Autor:
K. Saidas Nair, Chitrangda Srivastava, Robert V. Brown, Swanand Koli, Hélène Choquet, Hong Soon Kang, Yien-Ming Kuo, Sara A. Grimm, Caleb Sutherland, Alexandra Badea, G. Allan Johnson, Yin Zhao, Jie Yin, Kyoko Okamoto, Graham Clark, Terete Borrás, Gulab Zode, Krishnakumar Kizhatil, Subhabrata Chakrabarti, Simon W. M. John, Eric Jorgenson, Anton M. Jetten
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Dysfunction of the trabecular meshwork (TM) is the chief cause of elevated intraocular pressure, the major risk factor of glaucoma. Here, the authors identify the transcription factor, GLIS1, as a critical regulator of TM maintenance and intraocular
Externí odkaz:
https://doaj.org/article/1d13ccf102314720a834e165f6b1a62d
Autor:
Andrzej T. Slominski, Tae-Kang Kim, Shariq Qayyum, Yuwei Song, Zorica Janjetovic, Allen S. W. Oak, Radomir M. Slominski, Chander Raman, Joanna Stefan, Carlos A. Mier-Aguilar, Venkatram Atigadda, David K. Crossman, Andriy Golub, Yaroslav Bilokin, Edith K. Y. Tang, Jake Y. Chen, Robert C. Tuckey, Anton M. Jetten, Yuhua Song
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-23 (2021)
Abstract The interactions of derivatives of lumisterol (L3) and vitamin D3 (D3) with liver X receptors (LXRs) were investigated. Molecular docking using crystal structures of the ligand binding domains (LBDs) of LXRα and β revealed high docking sco
Externí odkaz:
https://doaj.org/article/25793fb5b8704b48b8b033ea0ef380e3
Autor:
Katharina R. Beck, Silvia G. Inderbinen, Sharavan Kanagaratnam, Denise V. Kratschmar, Anton M. Jetten, Hideaki Yamaguchi, Alex Odermatt
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 9, Pp 1535-1546 (2019)
Oxysterols previously were considered intermediates of bile acid and steroid hormone biosynthetic pathways. However, recent research has emphasized the roles of oxysterols in essential physiologic processes and in various diseases. Despite these disc
Externí odkaz:
https://doaj.org/article/05d2094e277b4194bbad67f4b6a2104a
Publikováno v:
Cells, Vol 11, Iss 11, p 1833 (2022)
The GLI-Similar 1-3 (GLIS1-3) genes, in addition to encoding GLIS1-3 Krüppel-like zinc finger transcription factors, also generate circular GLIS (circGLIS) RNAs. GLIS1-3 regulate gene transcription by binding to GLIS binding sites in target genes, w
Externí odkaz:
https://doaj.org/article/9149d68bfa6343d9b2927ab2bf07eeed
Autor:
David W. Scoville, Anton M. Jetten
Publikováno v:
Cells, Vol 10, Iss 12, p 3471 (2021)
Understanding of pancreatic islet biology has greatly increased over the past few decades based in part on an increased understanding of the transcription factors that guide this process. One such transcription factor that has been increasingly tied
Externí odkaz:
https://doaj.org/article/4456222782dc477d970250d0c9fdb676
Autor:
Anna A. Brożyna, Tae-Kang Kim, Marzena Zabłocka, Wojciech Jóźwicki, Junming Yue, Robert C. Tuckey, Anton M. Jetten, Andrzej T. Slominski
Publikováno v:
Nutrients, Vol 12, Iss 11, p 3541 (2020)
Vitamin D and its derivatives, acting via the vitamin D receptor (VDR) and retinoic acid-related orphan receptors γ and α (RORγ and RORα), show anticancer properties. Since pathological conditions are characterized by disturbances in the expressi
Externí odkaz:
https://doaj.org/article/ae16f12994194bf988ea95cc1db44f8b