Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Anton Khmelinskii"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Selective protein degradation typically involves substrate recognition via short linear motifs known as degrons. Various degrons can be found at protein termini from bacteria to mammals. While N-degrons have been extensively studied, our und
Externí odkaz:
https://doaj.org/article/4e6136608317460ebaa44ed60f00f3ce
Autor:
Natalie Schindler, Matthias Tonn, Vanessa Kellner, Jia Jun Fung, Arianna Lockhart, Olga Vydzhak, Thomas Juretschke, Stefanie Möckel, Petra Beli, Anton Khmelinskii, Brian Luke
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
RNase H2 removes mutagenic rNMPs from genomic DNA. The authors demonstrate how nicked rNMPs are repaired when they are encountered in S phase. This study unveils genetic interactions that could potentially be exploited in RNase H2-deficient pathologi
Externí odkaz:
https://doaj.org/article/1b537419c7dd48b7bcb6463d72ebc6a1
Autor:
Lukasz Kowalski, Piotr Bragoszewski, Anton Khmelinskii, Edyta Glow, Michael Knop, Agnieszka Chacinska
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-22 (2018)
Abstract Background The proteome of mitochondria comprises mostly proteins that originate as precursors in the cytosol. Before import into the organelle, such proteins are exposed to cytosolic quality control mechanisms. Multiple lines of evidence in
Externí odkaz:
https://doaj.org/article/751d52d59eb4477994728e03219815e5
Autor:
Ayse Koca Caydasi, Anton Khmelinskii, Rafael Duenas-Sanchez, Bahtiyar Kurtulmus, Michael Knop, Gislene Pereira
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The mitotic exit network (MEN) triggers mitotic exit and can be blocked by the spindle position checkpoint (SPOC). Here the authors show that SPOC kinase Kin4 counterbalances MEN activation by the Cdc fourteen early anaphase release (FEAR) network in
Externí odkaz:
https://doaj.org/article/069c4b5c13744c27951446be503830d8
Autor:
Elena Ivanova, Anton Khmelinskii
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 6, Pp 1-2 (2020)
Abstract Pooled genetic screening is a powerful method to systematically link genotype to phenotype and gain insights into biological processes, but applying it to visual phenotypes such as cell morphology or protein localization has remained a chall
Externí odkaz:
https://doaj.org/article/b24ebb9a93fb47a887634f501e90021a
Autor:
Verena Dederer, Anton Khmelinskii, Anna Gesine Huhn, Voytek Okreglak, Michael Knop, Marius K Lemberg
Publikováno v:
eLife, Vol 8 (2019)
Tail-anchored (TA) proteins insert post-translationally into the endoplasmic reticulum (ER), the outer mitochondrial membrane (OMM) and peroxisomes. Whereas the GET pathway controls ER-targeting, no dedicated factors are known for OMM insertion, posi
Externí odkaz:
https://doaj.org/article/c6f8f3892e2d41028bef137849c62e07
Autor:
Florian Huber, Daria Bunina, Ishaan Gupta, Anton Khmelinskii, Matthias Meurer, Patrick Theer, Lars M. Steinmetz, Michael Knop
Publikováno v:
Cell Reports, Vol 15, Iss 12, Pp 2625-2636 (2016)
Stable unannotated transcripts (SUTs), some of which overlap protein-coding genes in antisense direction, are a class of non-coding RNAs. While case studies have reported important regulatory roles for several of such RNAs, their general impact on pr
Externí odkaz:
https://doaj.org/article/e59889bda649405db0cd993dfe372a4a
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23794 (2011)
Gene tagging facilitates systematic genomic and proteomic analyses but chromosomal tagging typically disrupts gene regulatory sequences. Here we describe a seamless gene tagging approach that preserves endogenous gene regulation and is potentially ap
Externí odkaz:
https://doaj.org/article/590beabfb67f423ab195a666516835f7
Autor:
Natalie Schindler, Matthias Tonn, Vanessa Kellner, Jia Jun Fung, Arianna Lockhart, Olga Vydzhak, Thomas Juretschke, Stefanie Möckel, Petra Beli, Anton Khmelinskii, Brian Luke
Single ribonucleoside monophosphates (rNMPs) are transiently present in eukaryotic genomes. The RNase H2-dependent ribonucleotide excision repair (RER) pathway ensures error-free genomic rNMP removal. In pathological conditions, genomic rNMP levels c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fdd35ab5f1a871b09f7e99d0f65c11
https://doi.org/10.1101/2022.06.30.498227
https://doi.org/10.1101/2022.06.30.498227
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2378
Tandem fluorescent protein timers (tFTs) are versatile reporters of protein dynamics. A tFT consists of two fluorescent proteins with different maturation kinetics and provides a ratiometric readout of protein age, which can be exploited to follow in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b5bb4aed2a5ae0f80c5fb6774ff64a0
https://pubmed.ncbi.nlm.nih.gov/34985695
https://pubmed.ncbi.nlm.nih.gov/34985695