Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Anton Henssen"'
Publikováno v:
Cancer Medicine, Vol 13, Iss 20, Pp n/a-n/a (2024)
ABSTRACT Background Rhabdomyosarcoma (RMS) is a rare malignant soft tissue sarcoma (STS), accounting for almost 50% of pediatric STSs. Due to its heterogeneity, RMS presents challenges in diagnosis and treatment, with prognosis varying depending on m
Externí odkaz:
https://doaj.org/article/a67c1698fd844d1c9d678e354097b335
Autor:
Lena Andersch, Josefine Radke, Anika Klaus, Silke Schwiebert, Annika Winkler, Elisa Schumann, Laura Grunewald, Felix Zirngibl, Carina Flemmig, Michael C. Jensen, Claudia Rossig, Antonia Joussen, Anton Henssen, Angelika Eggert, Johannes H. Schulte, Annette Künkele
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-17 (2019)
Abstract Background Chimeric antigen receptor (CAR)-based T cell therapy is in early clinical trials to target the neuroectodermal tumor, neuroblastoma. No preclinical or clinical efficacy data are available for retinoblastoma to date. Whereas unilat
Externí odkaz:
https://doaj.org/article/5def686206a34ba99dda7e4365b95db8
Autor:
Bieke Decaesteker, Geertrui Denecker, Christophe Van Neste, Emmy M. Dolman, Wouter Van Loocke, Moritz Gartlgruber, Carolina Nunes, Fanny De Vloed, Pauline Depuydt, Karen Verboom, Dries Rombaut, Siebe Loontiens, Jolien De Wyn, Waleed M. Kholosy, Bianca Koopmans, Anke H. W. Essing, Carl Herrmann, Daniel Dreidax, Kaat Durinck, Dieter Deforce, Filip Van Nieuwerburgh, Anton Henssen, Rogier Versteeg, Valentina Boeva, Gudrun Schleiermacher, Johan van Nes, Pieter Mestdagh, Suzanne Vanhauwaert, Johannes H. Schulte, Frank Westermann, Jan J. Molenaar, Katleen De Preter, Frank Speleman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
In high-risk neuroblastoma cases, gains in chromosome 17q are common. Here, the authors investigate the epigenomics and transcriptomics of neuroblastoma, identifying TBX2 as a core regulatory circuitry component enhancing the reactivation of DREAM ta
Externí odkaz:
https://doaj.org/article/536b907629694780b1f507b113373066
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
Mechanisms of reduced cell viability induced by OTX015 are cell line dependent. OTX015 reduces cell proliferation over time and induces cell cycle changes as well as apoptosis. (a) Representative photomicrographs of neuroblastoma cell lines treated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6c21717502a0e406b5de6278290afd
https://doi.org/10.1158/1078-0432.22458717
https://doi.org/10.1158/1078-0432.22458717
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
All H3K27Ac peaks called in non-promoter regions in IMR5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0bdb3202921740e4a27fb7232c3f5c
https://doi.org/10.1158/1078-0432.22458729.v1
https://doi.org/10.1158/1078-0432.22458729.v1
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
OTX015 has no significant effect on non-malignant human fibroblasts. (a) Representative pictures of human fibroblasts treated for 72 h with 500 nM OTX015 or DMSO control. Scale bar=100 µm. (b) Growth of fibroblasts treated with 500 nM OTX015 (black)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079d20d24933361e5347a563449a502c
https://doi.org/10.1158/1078-0432.22458723
https://doi.org/10.1158/1078-0432.22458723
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
GSEA of gene sets describing general cellular processes after treatment with OTX015 and/or JQ1(GSEA, Broad institute)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342c4514be8e32a13a17e6c8666271cc
https://doi.org/10.1158/1078-0432.22458735.v1
https://doi.org/10.1158/1078-0432.22458735.v1
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
BET inhibition preferentially disrupts expression of genes associated with super-enhancers. (a) ChIP-seq profiles for H3K27Ac binding at representative super-enhancer-associated gene loci, including MYCN, NCOR2, BCOR and GLI2, in MYCN-amplified IMR-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde9e59bc7ca07c5c3ec4d2b98e90f35
https://doi.org/10.1158/1078-0432.22458705.v1
https://doi.org/10.1158/1078-0432.22458705.v1
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
GSEA of cancer gene sets after treatment with OTX015 and/or JQ1(GSEA, Broad institute)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8019254c454179edf44c85046656f67a
https://doi.org/10.1158/1078-0432.22458738.v1
https://doi.org/10.1158/1078-0432.22458738.v1
Autor:
Johannes H. Schulte, Esteban Cvitkovic, Angelika Eggert, Maria E. Riveiro, Lucile Astorgues-Xerri, Alexander Schramm, Natalie Sadowski, Sven Lindner, Kathy Astrahanseff, Annika Spruessel, Lukas Heukamp, Alexandra Florin, Katleen De Preter, Frank Westermann, Maike Nortmeyer, Emma Bell, Simon Schäfers, Frank Speleman, Richard Koche, Anneleen Beckers, Andrea Odersky, Kristina Althoff, Anton Henssen
BET bromodomain inhibition leads to disruption of MYCN driven gene-expression programs even at high levels of MYCN. (a) Enrichment of the published gene expression signature for JQ1-treated human MYCN-amplified neuroblastoma cell lines (11) in differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f15b6f946f7d96e97df919886734c08
https://doi.org/10.1158/1078-0432.22458708
https://doi.org/10.1158/1078-0432.22458708