Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Anton H. Poral"'
Autor:
Yasaman Barekatain, Jeffrey J. Ackroyd, Victoria C. Yan, Sunada Khadka, Lin Wang, Ko-Chien Chen, Anton H. Poral, Theresa Tran, Dimitra K. Georgiou, Kenisha Arthur, Yu-Hsi Lin, Nikunj Satani, Elliot S. Ballato, Eliot I. Behr, Ana C. deCarvalho, Roel G. W. Verhaak, John de Groot, Jason T. Huse, John M. Asara, Raghu Kalluri, Florian L. Muller
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The metabolite methylthioadenosine (MTA) inhibits PRMT5. Therefore, MTA accumulation due to MTA phosphorylase (MTAP) deletion has been proposed as a vulnerability for PRMT5-targeted therapy in cancer. Here, the authors show that MTA does not accumula
Externí odkaz:
https://doaj.org/article/52cd1479712f4a068ae698d7e4c9858e
Autor:
Victoria C. Yan, Cong-Dat Pham, Elliot S. Ballato, Kristine L. Yang, Kenisha Arthur, Sunada Khadka, Yasaman Barekatain, Prakriti Shrestha, Theresa Tran, Anton H. Poral, Mykia Washington, Sudhir Raghavan, Barbara Czako, Federica Pisaneschi, Yu-Hsi Lin, Nikunj Satani, Naima Hammoudi, Jeffrey J. Ackroyd, Dimitra K. Georgiou, Steven W. Millward, Florian L. Muller
Publikováno v:
Journal of Medicinal Chemistry. 65:13813-13832
Autor:
Kenisha Arthur, John M. Asara, Anton H. Poral, Nikunj Satani, Yu Hsi Lin, Raghu Kalluri, Florian L. Muller, Sunada Khadka, Dimitra K. Georgiou, Theresa Tran, Jeffrey J. Ackroyd, Jason T. Huse, Victoria C. Yan, Yasaman Barekatain, Eliot Itzkow Behr, Lin Wang, Ana C. deCarvalho, Ko Chien Chen, Elliot S. Ballato, John de Groot, Roel G.W. Verhaak
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Homozygous deletion of methylthioadenosine phosphorylase (MTAP) in cancers such as glioblastoma represents a potentially targetable vulnerability. Homozygous MTAP-deleted cell lines in culture show elevation of MTAP’s substrate metabolite, methylth
Autor:
Victoria C. Yan, Cong-Dat Pham, Elliot S. Ballato, Kristine L. Yang, Sunada Khadka, Yasaman Barektain, Prakriti Shrestha, Theresa Tran, Anton H. Poral, Mykia Washington, Sudhir Raghavan, Barbara Czako, Federica Pisaneschi, Yu-Hsi Lin, Nikunj Satani, Naima Hammoudi, Jeffrey J. Ackroyd, Dimitra K. Georgiou, Steven W. Millward, Florian L. Muller
Publikováno v:
Cancer Research. 83:3097-3097
Cancers harboring homozygous deletion of the glycolytic enzyme enolase 1 (ENO1) are selectively vulnerable to inhibition of the paralogous isoform, enolase 2 (ENO2). We previously identified and characterized a competitive, small molecule phosphonate
Autor:
Yasaman Barekatain, John M. Asara, Florian L. Muller, John de Groot, Theresa Tran, Sunada Khadka, Kenisha Arthur, Dimitra K. Georgiou, Jeffrey J. Ackroyd, Yu-Hsi Lin, Jason T. Huse, Anton H. Poral
Publikováno v:
Neuro Oncol
Angiogenesis inhibition has become a mainstay of oncology despite having fallen short of its early promise. As originally envisioned, angiogenesis inhibition would cut off the blood supply, deprive tumor cells of key nutrients, leading to their demis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9921307a3d5fb1eefaa28bf48b18926f
https://europepmc.org/articles/PMC7651226/
https://europepmc.org/articles/PMC7651226/
Autor:
Theresa Tran, Cong-Dat Pham, Anton H. Poral, Florian L. Muller, Elliot S. Ballato, Mykia Washington, Kenisha Arthur, Dimitra K. Georgiou, Prakriti Shrestha, Victoria C. Yan, Sunada Khadka, Kristine L. Yang, Matthew J. Yan
Publikováno v:
ACS Med Chem Lett
[Image: see text] Glycolysis inhibition remains aspirational in cancer therapy. We recently described a promising phosphonate inhibitor of enolase for cancers harboring homozygous deletions of ENO1. Here, we describe the application of a nitroheteroc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30588b038d854fa78430e16366cd14f
https://europepmc.org/articles/PMC7357215/
https://europepmc.org/articles/PMC7357215/
Autor:
Cong-Dat Pham, Kristine L. Yang, Anton H. Poral, Matthew J. Yan, Florian L. Muller, Victoria C. Yan, Hannah E. Butterfield
Publikováno v:
Trends Cancer
Chemotherapy is central to oncology, perceived to operate only on prolific cancerous tissue. Yet, many non-neoplastic tissues are more prolific compared with typical tumors. Chemotherapies achieve sufficient therapeutic windows to exert antineoplasti
Autor:
Ana C. deCarvalho, Kenisha Arthur, Anton H. Poral, John M. Asara, Nikunj Satani, Yu Hsi Lin, John de Groot, Dimitra K. Georgiou, Theresa Tran, Roeland Verhaak, Victoria C. Yan, Jeffrey J. Ackroyd, Jason T. Huse, Yasaman Barekatain, Florian L. Muller, Elliot S. Ballato
In BriefThe co-deletion ofMTAPin theCDKN2Alocus is a frequent event in diverse cancers including glioblastoma. Recent publications report that significant accumulations of the MTAP substrate, methylthioadenosine (MTA), can sensitizeMTAP-deleted cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5104540bcb859cd8d69fbc9e6da838e