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pro vyhledávání: '"Anton Dorph-Pedersen"'
Autor:
Folmer Nielsen-Kudsk, Steffen Hvidt, Niels Anders Klitgaard, Knud Erik Pedersen, Karen Kjær, Anton Dorph-Pedersen
Publikováno v:
Clinical Pharmacology and Therapeutics. 32:562-565
Verapamil has been shown to reduce total-body digoxin clearance by 35% due to impairments of both renal and extrarenal clearances. Our study was undertaken to evaluate the influence of the related calcium antagonist nifedipine on single-dose digoxin
Autor:
Steffen Hvidt, Niels Anders Klitgaard, Anton Dorph-Pedersen, Folmer Nielsen-Kudsk, Knud Erik Pedersen
Publikováno v:
Clinical Pharmacology and Therapeutics. 30:311-316
To explore a possible interaction between digoxin and verapamil, a single-dose kinetic study of digoxin was performed and then repeated after 10 days of verapamil treatment in eight healthy subjects. Verapamil diminished the apparent central distribu
Autor:
Steffen Hvidt, Niels Anders Klitgaard, K K Pedersen, Knud Erik Pedersen, Anton Dorph-Pedersen
Publikováno v:
European journal of clinical pharmacology. 22(2)
Single-dose investigations in healthy subjects have demonstrated substantial impairment of renal and extrarenal clearance of digoxin during coadministration of verapamil. A longitudinal study has been performed to assess the changes in digoxin dispos