Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Anton Crombach"'
Publikováno v:
IEEE Access, Vol 12, Pp 163079-163092 (2024)
With the ever-increasing influence of machine learning models, it has become necessary to explain their predictions. The SHAP framework provides a solution to this problem by assigning a score to each feature of a model such that it reflects the feat
Externí odkaz:
https://doaj.org/article/3f7c9b24abb843bdab8dfd1282d3d785
Autor:
Sara Zeppilli, Tobias Ackels, Robin Attey, Nell Klimpert, Kimberly D Ritola, Stefan Boeing, Anton Crombach, Andreas T Schaefer, Alexander Fleischmann
Publikováno v:
eLife, Vol 10 (2021)
Projection neurons (PNs) in the mammalian olfactory bulb (OB) receive input from the nose and project to diverse cortical and subcortical areas. Morphological and physiological studies have highlighted functional heterogeneity, yet no molecular marke
Externí odkaz:
https://doaj.org/article/9685d58b0eb44b04902fd781b4e922aa
Autor:
Berta Verd, Erik Clark, Karl R Wotton, Hilde Janssens, Eva Jiménez-Guri, Anton Crombach, Johannes Jaeger
Publikováno v:
PLoS Biology, Vol 16, Iss 2, p e2003174 (2018)
Insects determine their body segments in two different ways. Short-germband insects, such as the flour beetle Tribolium castaneum, use a molecular clock to establish segments sequentially. In contrast, long-germband insects, such as the vinegar fly D
Externí odkaz:
https://doaj.org/article/80f84b8517e942bbb9db2bc49e8575f3
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 2, p e1005285 (2017)
Pattern formation during development is a highly dynamic process. In spite of this, few experimental and modelling approaches take into account the explicit time-dependence of the rules governing regulatory systems. We address this problem by studyin
Externí odkaz:
https://doaj.org/article/8f1d12a935ba424baef8c29ac233eb34
Autor:
Karl R Wotton, Eva Jiménez-Guri, Anton Crombach, Hilde Janssens, Anna Alcaine-Colet, Steffen Lemke, Urs Schmidt-Ott, Johannes Jaeger
Publikováno v:
eLife, Vol 4 (2015)
The segmentation gene network in insects can produce equivalent phenotypic outputs despite differences in upstream regulatory inputs between species. We investigate the mechanistic basis of this phenomenon through a systems-level analysis of the gap
Externí odkaz:
https://doaj.org/article/2070acfada30441ab4cc352781a9eac7
Publikováno v:
Computation, Vol 5, Iss 2, p 22 (2017)
Efficient network inference is one of the challenges of current-day biology. Its application to the study of development has seen noteworthy success, yet a multicellular context, tissue growth, and cellular rearrangements impose additional computatio
Externí odkaz:
https://doaj.org/article/7d4c1f3659714ea2a8c7be18749c1d81
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 7, p e1002589 (2012)
Understanding the complex regulatory networks underlying development and evolution of multi-cellular organisms is a major problem in biology. Computational models can be used as tools to extract the regulatory structure and dynamics of such networks
Externí odkaz:
https://doaj.org/article/ce2ba95e187e43409a06b104151e14c1
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46658 (2012)
Understanding the function and evolution of developmental regulatory networks requires the characterisation and quantification of spatio-temporal gene expression patterns across a range of systems and species. However, most high-throughput methods to
Externí odkaz:
https://doaj.org/article/c3622fb115044f5b9bcc942e3a5e3519
Autor:
Anton Crombach, Paulien Hogeweg
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 7, p e1000112 (2008)
Gene regulatory networks are perhaps the most important organizational level in the cell where signals from the cell state and the outside environment are integrated in terms of activation and inhibition of genes. For the last decade, the study of su
Externí odkaz:
https://doaj.org/article/343b67f1fad9401fa81b4a135b56b5b7
Autor:
Anton Crombach
Publikováno v:
Anton Crombach. Springer International Publishing, pp.1-294, 2021, 978-3-030-71736-0. ⟨10.1007/978-3-030-71737-7⟩
International audience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daca85c65e615ba50c0401278a2bbecc
https://hal.archives-ouvertes.fr/hal-03473679
https://hal.archives-ouvertes.fr/hal-03473679
