Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Anton A. Buzdin"'
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Cancer chimeric, or fusion, transcripts are thought to most frequently appear due to chromosomal aberrations that combine moieties of unrelated normal genes. When being expressed, this results in chimeric RNAs having upstream and downstream parts rel
Externí odkaz:
https://doaj.org/article/baead3a859174dd691a5185c268c0a25
Autor:
Maksim Sorokin, Anton A. Buzdin, Anastasia Guryanova, Victor Efimov, Maria V. Suntsova, Marianna A. Zolotovskaia, Elena V. Koroleva, Marina I. Sekacheva, Victor S. Tkachev, Andrew Garazha, Kristina Kremenchutckaya, Aleksey Drobyshev, Aleksander Seryakov, Alexander Gudkov, Irina V. Alekseenko, Olga Rakitina, Maria B. Kostina, Uliana Vladimirova, Aleksey Moisseev, Dmitry Bulgin, Elena Radomskaya, Viktor Shestakov, Vladimir P. Baklaushev, Vladimir Prassolov, Petr V. Shegay, Xinmin Li, Elena V. Poddubskaya, Nurshat Gaifullin
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3964-3986 (2023)
Normal tissues are essential for studying disease-specific differential gene expression. However, healthy human controls are typically available only in postmortal/autopsy settings. In cancer research, fragments of pathologically normal tissue adjace
Externí odkaz:
https://doaj.org/article/bf4fa9cc991740c98706b792903a2914
Autor:
Julian M. Rozenberg, Anton A. Buzdin, Tharaa Mohammad, Olga A. Rakitina, Dmitry A. Didych, Victor V. Pleshkan, Irina V. Alekseenko
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Treatment of metastatic disease remains among the most challenging tasks in oncology. One of the early events that predicts a poor prognosis and precedes the development of metastasis is the occurrence of clusters of cancer cells in the blood flow. M
Externí odkaz:
https://doaj.org/article/762a5fffdaa14ad1b22afcb5d9d42de9
Autor:
Marianna A. Zolotovskaia, Victor S. Tkachev, Anastasia A. Guryanova, Alexander M. Simonov, Mikhail M. Raevskiy, Victor V. Efimov, Ye Wang, Marina I. Sekacheva, Andrew V. Garazha, Nicolas M. Borisov, Denis V. Kuzmin, Maxim I. Sorokin, Anton A. Buzdin
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2280-2291 (2022)
OncoboxPD (Oncobox pathway databank) available at https://open.oncobox.com is the collection of 51 672 uniformly processed human molecular pathways. Superposition of all pathways formed interactome graph of protein–protein interactions and metaboli
Externí odkaz:
https://doaj.org/article/b245b73cfa724537ad4253da67e83fa8
Autor:
Marianna Zolotovskaia, Maks Kovalenko, Polina Pugacheva, Victor Tkachev, Alexander Simonov, Maxim Sorokin, Alexander Seryakov, Andrew Garazha, Nurshat Gaifullin, Marina Sekacheva, Galina Zakharova, Anton A. Buzdin
Publikováno v:
Proteomes, Vol 11, Iss 3, p 26 (2023)
Individual gene expression and molecular pathway activation profiles were shown to be effective biomarkers in many cancers. Here, we used the human interactome model to algorithmically build 7470 molecular pathways centered around individual gene pro
Externí odkaz:
https://doaj.org/article/ad117488a3bc4345bdbae550b0a3ed52
Autor:
Maria V. Suntsova, Anton A. Buzdin
Publikováno v:
BMC Genomics, Vol 21, Iss S7, Pp 1-12 (2020)
Abstract Chimpanzees are the closest living relatives of humans. The divergence between human and chimpanzee ancestors dates to approximately 6,5–7,5 million years ago. Genetic features distinguishing us from chimpanzees and making us humans are st
Externí odkaz:
https://doaj.org/article/632f063a96a44ba7b9833e3b1f246622
Autor:
Elizaveta Rabushko, Maxim Sorokin, Maria Suntsova, Alexander P. Seryakov, Denis V. Kuzmin, Elena Poddubskaya, Anton A. Buzdin
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 1866 (2022)
Drugs targeting receptor tyrosine kinase (RTK) oncogenic fusion proteins demonstrate impressive anti-cancer activities. The fusion presence in the cancer is the respective drug prescription biomarker, but their identification is challenging as both t
Externí odkaz:
https://doaj.org/article/b0c9fe5046ff4fc99785f002536ab0b9
Autor:
Marianna A. Zolotovskaia, Max A. Kovalenko, Victor S. Tkachev, Alexander M. Simonov, Maxim I. Sorokin, Ella Kim, Denis V. Kuzmin, Betul Karademir-Yilmaz, Anton A. Buzdin
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7330 (2022)
In gliomas, expression of certain marker genes is strongly associated with survival and tumor type and often exceeds histological assessments. Using a human interactome model, we algorithmically reconstructed 7494 new-type molecular pathways that are
Externí odkaz:
https://doaj.org/article/617e40bdfe5a421893e88a4919d63943
Publikováno v:
Viruses, Vol 13, Iss 12, p 2396 (2021)
LINE1 retrotransposons, which are thought to be the remnants of ancient integrations of retrovirus-like elements, are aberrantly (re)activated in many cancer cells. Due to LINE1-induced alterations in target gene expression and/or chromosomal rearran
Externí odkaz:
https://doaj.org/article/436624fe208b4cc78d6684f453c6bc80
Autor:
Marianna A. Zolotovskaia, Maxim I. Sorokin, Sergey A. Roumiantsev, Nikolay M. Borisov, Anton A. Buzdin
Publikováno v:
Frontiers in Oncology, Vol 8 (2019)
DNA mutations play a crucial role in cancer development and progression. Mutation profiles vary dramatically in different cancer types and between individual tumors. Mutations of several individual genes are known as reliable cancer biomarkers, altho
Externí odkaz:
https://doaj.org/article/9d5a087202d843fda65d7799bc1bf3b5