Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Anton A Komar"'
Autor:
Kepeng Che, Ajaybabu V Pobbati, Caleb N Seavey, Yuriy Fedorov, Anton A Komar, Ashley Burtscher, Shuang Ma, Brian P Rubin
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0266143 (2022)
Disrupting the formation of the oncogenic YAP/TAZ-TEAD transcriptional complex holds substantial therapeutic potential. However, the three protein interaction interfaces of this complex cannot be easily disrupted using small molecules. Here, we repor
Externí odkaz:
https://doaj.org/article/8a4ef1a458ba481fb6afe6bc523ac235
Autor:
David Holcomb, Aikaterini Alexaki, Nancy Hernandez, Ryan Hunt, Kyle Laurie, Jacob Kames, Nobuko Hamasaki-Katagiri, Anton A Komar, Michael DiCuccio, Chava Kimchi-Sarfaty
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 3, p e1008805 (2021)
Thrombosis is a recognized complication of Coronavirus disease of 2019 (COVID-19) and is often associated with poor prognosis. There is a well-recognized link between coagulation and inflammation, however, the extent of thrombotic events associated w
Externí odkaz:
https://doaj.org/article/518b9cb3c9e9405bb80b8b976a90bf35
Autor:
Sarah E. Fumagalli, Sean Smith, Tigran Ghazanchyan, Douglas Meyer, Rahul Paul, Collin Campbell, Luis Santana-Quintero, Anton Golikov, Juan Ibla, Haim Bar, Anton A. Komar, Ryan C. Hunt, Brian Lin, Michael DiCuccio, Chava Kimchi-Sarfaty
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Mouse (Mus musculus) models have been heavily utilized in developmental biology research to understand mammalian embryonic development, as mice share many genetic, physiological, and developmental characteristics with humans. New exploration
Externí odkaz:
https://doaj.org/article/4ba89a888fe44f0d801eb3f593533bc8
Autor:
Anton A Komar, Maria eHatzoglou
Publikováno v:
Frontiers in Oncology, Vol 5 (2015)
Initiation of eukaryotic mRNA translation may proceed via several different routes, each requiring a different subset of factors and relying on different and specific interactions between the mRNA and the ribosome. Two modes predominate: (i) so-calle
Externí odkaz:
https://doaj.org/article/355b3ce17186445fb8c352647e94047b
Autor:
Nathan C Edwards, Zachary A Hing, Avital Perry, Adam Blaisdell, David B Kopelman, Robert Fathke, William Plum, Jordan Newell, Courtni E Allen, Geetha S, Aaron Shapiro, Chinyere Okunji, Idit Kosti, Noam Shomron, Vahan Grigoryan, Teresa M Przytycka, Zuben E Sauna, Raheleh Salari, Yael Mandel-Gutfreund, Anton A Komar, Chava Kimchi-Sarfaty
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38864 (2012)
Synonymous variations, which are defined as codon substitutions that do not change the encoded amino acid, were previously thought to have no effect on the properties of the synthesized protein(s). However, mounting evidence shows that these "silent"
Externí odkaz:
https://doaj.org/article/1425d58426564ce68f4b13d5944197e4
Autor:
Sarah E. Fumagalli, Nigam H. Padhiar, Douglas Meyer, Upendra Katneni, Haim Bar, Michael DiCuccio, Anton A. Komar, Chava Kimchi-Sarfaty
Publikováno v:
Virology Journal. 20
Background Since the onset of the SARS-CoV-2 pandemic, bioinformatic analyses have been performed to understand the nucleotide and synonymous codon usage features and mutational patterns of the virus. However, comparatively few have attempted to perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90af02e01e9dc4882cd1b922598e53ac
https://doi.org/10.1186/s12985-023-01982-8
https://doi.org/10.1186/s12985-023-01982-8
Autor:
David D. Holcomb, Katarzyna I. Jankowska, Nancy Hernandez, Kyle Laurie, Jacob Kames, Nobuko Hamasaki-Katagiri, Anton A. Komar, Michael DiCuccio, Chava Kimchi-Sarfaty
Publikováno v:
STAR protocols. 3(3)
Here, we describe a bioinformatics pipeline that evaluates the interactions between coagulation-related proteins and genetic variants with SARS-CoV-2 proteins. This pipeline searches for host proteins that may bind to viral protein and identifies and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b918857a464eedce58c67b3ca0e815bf
https://pubmed.ncbi.nlm.nih.gov/36052345
https://pubmed.ncbi.nlm.nih.gov/36052345
Autor:
Anton A. Komar
Publikováno v:
Biochemistry (Mosc)
The genetic code sets the correspondence between the sequence of a given nucleotide triplet in an mRNA molecule, called a codon, and the amino acid that is added to the growing polypeptide chain during protein synthesis. With four bases (A, G, U, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5866b501a1f26db5915b14eae50174
https://doi.org/10.1134/s0006297921080083
https://doi.org/10.1134/s0006297921080083
Autor:
Anton A. Komar
Publikováno v:
Cell cycle (Georgetown, Tex.). 21(16)
Protein folding in the cell is largely a co-translational process occurring during protein synthesis on the ribosome. It has become evident that co-translational folding is characteristic to almost every protein in the cell of pro- and eukaryotic ori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ec1a346c290268eff0aecb99dabde9
https://pubmed.ncbi.nlm.nih.gov/34994471
https://pubmed.ncbi.nlm.nih.gov/34994471
Autor:
Upendra K. Katneni, Aikaterini Alexaki, Ryan C. Hunt, Nobuko Hamasaki-Katagiri, Gaya K. Hettiarachchi, Jacob M. Kames, Joseph R. McGill, David D. Holcomb, John C. Athey, Brian Lin, Leonid A. Parunov, Tal Kafri, Qi Lu, Robert Peters, Mikhail V. Ovanesov, Darón I. Freedberg, Haim Bar, Anton A. Komar, Zuben E. Sauna, Chava Kimchi-Sarfaty
Publikováno v:
Blood advances. 6(13)
Hemophilia B is a blood clotting disorder caused by deficient activity of coagulation factor IX (FIX). Multiple recombinant FIX proteins are currently approved to treat hemophilia B, and several gene therapy products are currently being developed. Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b99eea64d9777826b0635aaa2167bc
https://pubmed.ncbi.nlm.nih.gov/35413099
https://pubmed.ncbi.nlm.nih.gov/35413099