Circulating Fibronectin Controls Tumor Growth

Autor: Anja von Au, Matthaeus Vasel, Sabrina Kraft, Carla Sens, Norman Hackl, Alexander Marx, Philipp Stroebel, Jörg Hennenlotter, Tilman Todenhöfer, Arnulf Stenzl, Sarah Schott, Hans-Peter Sinn, Antoinette Wetterwald, Justo Lorenzo Bermejo, Marco G Cecchini, Inaam A Nakchbandi

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 8, Pp 925-938 (2013)

Fibronectin is ubiquitously expressed in the extracellular matrix, and experimental evidence has shown that it modulates blood vessel formation. The relative contribution of local and circulating fibronectin to blood vessel formation in vivo remains

Externí odkaz: https://doaj.org/article/1bd397fdc23c48fda9dccebf2d503938

The role of the BMP signaling antagonist noggin in the development of prostate cancer osteolytic bone metastasis.

Autor: Chiara Secondini, Antoinette Wetterwald, Ruth Schwaninger, George N Thalmann, Marco G Cecchini

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e16078 (2011)

Members of the BMP and Wnt protein families play a relevant role in physiologic and pathologic bone turnover. Extracellular antagonists are crucial for the modulation of their activity. Lack of expression of the BMP antagonist noggin by osteoinductiv

Externí odkaz: https://doaj.org/article/61c74838c5f943d48a272a0d4383c217

Osteolytic cancer cells induce vascular/axon guidance processes in the bone/bone marrow stroma

Autor: Carsten Riether, Gabri van der Pluijm, Marco G. Cecchini, Antoinette Wetterwald, Ramzi Temanni, Irene Keller, George N. Thalmann, Janine Hensel

Publikováno v: Oncotarget
Hensel, Janine; Wetterwald, Antoinette; Temanni, Ramzi; Keller, Irene; Riether, Carsten; van der Pluijm, Gabri; Cecchini, Marco G; Thalmann, George N. (2018). Osteolytic cancer cells induce vascular/axon guidance processes in the bone/bone marrow stroma. OncoTarget, 9(48), pp. 28877-28896. Impact Journals LLC 10.18632/oncotarget.25608

Prostate and breast cancers frequently metastasize to bone. The physiological bone homeostasis is perturbed once cancer cells proliferate at the bone metastatic site. Tumors are complex structures consisting of cancer cells and numerous stroma cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301138042de4e1ccad94b25ee6dd3b88

Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases

Autor: Walter Pyerin, Clemens W.G.M. Löwik, Cyrill A. Rentsch, George N. Thalmann, Gabri van der Pluijm, Ruth Schwaninger, Freddie C. Hamdy, Antoinette Wetterwald, Geertje van der Horst, Rutger L. van Bezooijen, Karin Ackermann, Marco G. Cecchini

Prostate and mammary cancer bone metastases can be osteoblastic or osteolytic, but the mechanisms determining these features are unclear. Bone morphogenetic and Wnt proteins are osteoinductive molecules. Their activity is modulated by antagonists suc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e691fc6c106470bc75a3f4898c81e2ca
https://doi.org/10.2353/ajpath.2007.051276

Stem-Like Cells with Luminal Progenitor Phenotype Survive Castration in Human Prostate Cancer

Autor: Gabri van der Pluijm, George N. Thalmann, Markus Germann, Natalia Guzmán-Ramírez, Elizabeth D. Williams, Antoinette Wetterwald, Zoran Culig, Marco G. Cecchini

Publikováno v: STEM CELLS, 30(6), 1076-1086
Cancer Stem Cells

Castration is the standard therapy for advanced prostate cancer (PC). Although this treatment is initially effective, tumors invariably relapse as incurable, castration-resistant PC (CRPC). Adaptation of androgen-dependent PC cells to an androgen-dep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01083b0bc23e3c474597f590806e66e
https://doi.org/10.1002/stem.1087