Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Antoinette Viger"'
Autor:
Thomas E. Mulligan, Lana Gabriel, Jianguo Zhi, Christoph Funk, Berthold Lausecker, Ka Wang, Angela T. Melia, Antoinette Viger-Chougnet, Jeffrey S. Fulton, Gérard Hopfgartner
Publikováno v:
The Journal of Clinical Pharmacology. 36:1006-1011
To determine the metabolic profile of minimally absorbed orlistat in obese/overweight patients, an open-label, single-dose study was performed in eight obese/overweight volunteers between 23 and 68 years of age. Each subject received a single oral do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89065e0867a7147989ac3c4d76b70b7c
https://doi.org/10.1177/009127009603601104
https://doi.org/10.1177/009127009603601104
Publikováno v:
European Journal of Biochemistry. 232:247-256
The last step of aldosterone biosynthesis, an 11 beta-hydroxylation followed by two 18-hydroxylations, are catalyzed, in the bovine system, by the same enzyme, the cytochrome P-450(11 beta) (deoxycorticosterone (DOC)-->corticosterone-->18-hydroxycort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134298f40bc07a1f35491bd36fda0bb6
https://doi.org/10.1111/j.1432-1033.1995.tb20806.x
https://doi.org/10.1111/j.1432-1033.1995.tb20806.x
Publikováno v:
Tetrahedron. 47:7309-7322
Androst-4-en-3-one derivatives substituted at the 18-methyl group bearing a 17-keto or 17-spirolactone function have been synthesized and tested in vitro as inhibitors of aldosterone biosynthesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75de13bca31ec0fd2745e7160f3227fe
https://doi.org/10.1016/s0040-4020(01)89733-7
https://doi.org/10.1016/s0040-4020(01)89733-7
Publikováno v:
Journal of Crystallographic and Spectroscopic Research. 20:429-432
The crystal structure of 18-cyanoprogesterone was determined by X-ray diffraction methods:P212121a=7.436(2),b=11.322(2),c=22.642(2) A. The structure was solved usingShelx-86. Final conventionalR=0.054.Rw=0.051 for 1841 reflections. TheA ring has an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7be7a8611ef9ab04ff4271347de8a1fc
https://doi.org/10.1007/bf01180109
https://doi.org/10.1007/bf01180109
Publikováno v:
Steroids. 55:271-275
The synthesis of new 18- or 18'-thioether derivatives of progesterone are reported, along with acid-catalyzed rearrangements occurring during the thioacetalization reactions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e15c2032d19396cec207f858c960a7
https://doi.org/10.1016/0039-128x(90)90044-c
https://doi.org/10.1016/0039-128x(90)90044-c
Publikováno v:
Steroids. 58(3)
We describe the synthesis of 13β- and 13α-H-18-nor-androst-4-ene-3,17-dione ( 1a and 1b ) from 18-hydroxyprogesterone (18 → 20) hemiketal, via the 18-acetoxy-17β-hydroxyandrost-4-en-3-one formed by a modified Baeyer-Villiger reaction. Saponifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ace3713d041515b4ad2dc6b7b2f186
https://pubmed.ncbi.nlm.nih.gov/8475519
https://pubmed.ncbi.nlm.nih.gov/8475519
Publikováno v:
Journal of the American Chemical Society. 103:451-458
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e17c292627b679a2cb3ba9a62c0c354
https://doi.org/10.1021/ja00392a034
https://doi.org/10.1021/ja00392a034
Publikováno v:
Tetrahedron. 35:1657-1663
Resume L'effet Cotton associe aux alkylidenes-17 (5α) androstanes est discute. Les variations importantes du dichroisme circulaire observees ne sont pas dues a la torsion de la liaison ethylenique dans l'etat fondamental. Le modele A.B.P. permet d'a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::157ac6b49646fd060a2de7caed20fb04
https://doi.org/10.1016/0040-4020(79)80030-7
https://doi.org/10.1016/0040-4020(79)80030-7
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :1937-1940
Reduction of 3β-benzoyloxycholest-5-en-4-one (3) with sodium borohydride under various conditions affords only minor amounts of 3β-benzoyloxycholest-5-en-4β-ol (2a). The major product is the 4α-isomer (6). Using sodium borodeuteride it has been s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caf0452176c545a16eded65e45827656
https://doi.org/10.1039/p19820001937
https://doi.org/10.1039/p19820001937
Publikováno v:
Journal of Steroid Biochemistry. 30:469-472
A new family of aldosterone biosynthesis inhibitors, designed as 18-mono-oxygenase, cytochrome-P450-dependent, potential Kcat inhibitors, is described. These compounds are progesterone derivatives substituted at the 18-methyl group. Preliminary resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6911e596af4b22b7bbe18b435a52283e
https://doi.org/10.1016/0022-4731(88)90145-8
https://doi.org/10.1016/0022-4731(88)90145-8