Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Antoinette Naylor"'
Autor:
Beverley Smith, Alessandra Gaiba, Jon Graham Anthony Steadman, Penelope C. Staton, Antoinette Naylor, David Matthew Wilson, Robert P. Davis, Susannah Davies, Tania O. Stean, Alastair D. Reith, Mark James Bamford, Christopher A. Parr, David Kenneth Dean, Frank D. King, Andrew K. Takle, Elaine A. Irving, Alison M. Ray
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4373-4376
Modification of the potent imidazole-based B-Raf inhibitor SB-590885 resulted in the identification of a series of furan-based derivatives with enhanced CNS penetration. One such compound, SB-699393 (17), was examined in vivo to challenge the hypothe
Autor:
Eric Hunt, Andrew K. Takle, A. J. Eglington, J. D. Hinks, Steven Coulton, George Burton, S. F. Moss, Antoinette Naylor, R K Holland, Michael J. Pearson, Clive Leslie Branch, Sarah J. Knott, G. J. Clarke, J. D. Douglas, A. W. Guest, N. W. Hird
Publikováno v:
The Journal of Antibiotics. 51:210-220
The synthesis, antibacterial activity, and stability to human dehydropeptidase-1 (DHP-1) of a novel series of (5R,6S)-6-[(1R)-1-hydroxyethyl]-2-heterocyclylcarbapen-2-em-3-carb oxylates are described. Of the compounds investigated 1,5-disubstituted p
Autor:
G. J. Clarke, A. J. Eglington, Eric Hunt, Antoinette Naylor, N. W. Hird, George Burton, J. D. Douglas, J. D. Hinks, S. F. Moss, C. H. Frydrych, N. H. Nicholson, Michael J. Pearson
Publikováno v:
The Journal of Antibiotics. 49:1266-1274
A series of carbapenems containing novel C-2 semisaturated heterocyclic substituents were synthesised by 1, 3 dipolar cycloaddition reactions of nitrile oxides, nitrile imines and a nitrone to 2-vinylcarbapenem. The isoxazoline and isoxazolidine comp
Publikováno v:
Tetrahedron. 51:8655-8664
Routes to derivatives of the 6,7-benzo-1-azabicyclo[3.2.0]heptyl ring system are described; the relative ability of substituted aryl rings to participate in selective reaction of the anti - invertomers of the title compounds during Ag(I)-catalysed me
Publikováno v:
Tetrahedron. 49:451-468
Publikováno v:
ChemInform. 24
Publikováno v:
ChemInform. 24
Publikováno v:
ChemInform. 26
Routes to derivatives of the 6,7-benzo-1-azabicyclo[3.2.0]heptyl ring system are described; the relative ability of substituted aryl rings to participate in selective reaction of the anti - invertomers of the title compounds during Ag(I)-catalysed me
Autor:
Eric Hunt, A. J. Eglington, N. J. C. Clear, Michael J. Pearson, Antoinette Naylor, George Burton, Angela W. Guest, Andrew K. Takle
Publikováno v:
ChemInform. 28
Autor:
G. J. Clarke, N. W. Hird, N. H. Nicholson, George Burton, A. J. Eglington, J. D. Hinks, Michael J. Pearson, Antoinette Naylor, Stephen Moss, Eric Hunt, C. H. Frydrych, J. D. Douglas
Publikováno v:
ChemInform. 28