Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Antoinette B. Hartman"'
Publikováno v:
Journal of Clinical Microbiology. 41:1023-1032
To make a comprehensive study of tetracycline resistance determinant distribution in the genus Shigella , a collection of 577 clinical isolates of Shigella spp. and enteroinvasive Escherichia coli (EIEC) from a variety of geographical locations was s
Autor:
Thomas L. Hale, David N. Taylor, William D. Picking, James D. Campbell, Steven S. Wasserman, Marcelo B. Sztein, Myron M. Levine, Karen L. Kotloff, Antoinette B. Hartman, David E. Katz, Genevieve Losonsky, Malabi M. Venkatesan, James P. Nataro
Publikováno v:
Infection and Immunity. 70:2016-2021
We conducted a phase I trial with healthy adults to evaluate WRSS1, a live, oral Δ virG Shigella sonnei vaccine candidate. In a double-blind, randomized, dose-escalating fashion, inpatient volunteers received a single dose of either placebo ( n = 7)
Autor:
Scott A. Hammond, Evelina Angov, Tanya Scharton-Kersten, Carl R. Alving, Jianmei Yu, Frederick J. Cassels, Antoinette B. Hartman, Gregory M. Glenn, Blaise Corthésy
Publikováno v:
Infection and Immunity. 70:1056-1068
EnterotoxigenicEscherichia coli(ETEC) diarrheal disease is a worldwide problem that may be addressed by transcutaneous delivery of a vaccine. In several human settings, protective immunity has been associated with immune responses toE. colicolonizati
Publikováno v:
Infection and Immunity. 68:6624-6632
The invasiveness and virulence of Shigella spp. are largely due to the expression of plasmid-encoded virulence factors, among which are the invasion plasmid antigens (Ipa proteins). After infection, the host immune response is directed primarily agai
Autor:
Malabi M. Venkatesan, Carmen M. Fernandez-Prada, Antoinette B. Hartman, June Kopelowitz, Ben D. Tall, David L. Hoover
Publikováno v:
Infection and Immunity. 68:3608-3619
The behavior ofShigella flexneri ipaHmutants was studied in human monocyte-derived macrophages (HMDM), in 1-day-old human monocytes, and in J774 mouse macrophage cell line. In HMDM, strain pWR700, anipaH7.8deletion mutant ofS. flexneri2a strain 2457T
Publikováno v:
Infection and Immunity. 67:5841-5847
Both native and mutant forms of cholera toxin (CT) and heat-labile enterotoxin (LT) are effective adjuvants for antigens and killed whole-cell preparations. To determine whether these toxin molecules could also boost the immunogenicity and efficacy o
Publikováno v:
Infection and Immunity. 66:4572-4576
Construction of a stable Shigella sonnei vaccine has been complicated by the instability of the virulence phenotype caused by the spontaneous loss of the invasion plasmid. To select a suitable candidate for vaccine construction, 16 S. sonnei strains
Autor:
J L Puryear, N O Bendiuk, Antoinette B. Hartman, David N. Taylor, J L Ruckert, M M Marsh, L L Van De Verg, Karen L. Kotloff
Publikováno v:
Vaccine. 14:1062-1068
To study the cross-reactivity pattern of Shigella flexneri 2a O-antigen antibodies, sera from humans and monkeys challenged with S. flexneri 2a, and from humans and guinea pigs immunized with a recombinant vaccine expressing serotype 2a O-antigen, we
Publikováno v:
Molecular Microbiology. 5:2435-2445
Summary Oligonucleotide primers derived from the ipaH7.8 sequence have been used to determine the boundaries of DNA sequence homology among five lpaH genes on the invasion plasmid (pWR100) of Shigella flexneri 5, strain M9OT-W. The primary structure
Autor:
Malabi M. Venkatesan, A. A. Franco, R. B. Sack, Antoinette B. Hartman, C. F. Lanata, W. Spira, Carmen M. Fernandez-Prada
Publikováno v:
Epidemiology and infection. 132(2)
A year-long community-based study of diarrhoeal diseases was conducted in Canto Grande, a periurban community in Lima, Peru. In 109 (34%) houses out of 323 that were visited, at least one individual was detected with shigellosis. The frequency of the