Limited evidence for blood eQTLs in human sexual dimorphism

Autor: Eleonora Porcu, Annique Claringbould, Antoine Weihs, Kaido Lepik, BIOS Consortium, Tom G. Richardson, Uwe Völker, Federico A. Santoni, Alexander Teumer, Lude Franke, Alexandre Reymond, Zoltán Kutalik

Publikováno v: Genome Medicine, Vol 14, Iss 1, Pp 1-13 (2022)

Abstract Background The genetic underpinning of sexual dimorphism is very poorly understood. The prevalence of many diseases differs between men and women, which could be in part caused by sex-specific genetic effects. Nevertheless, only a few publis

Externí odkaz: https://doaj.org/article/a3f5c3b678794a75addbb623225d2106

Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus

Autor: Adrienne Tin, Pascal Schlosser, Pamela R. Matias-Garcia, Chris H. L. Thio, Roby Joehanes, Hongbo Liu, Zhi Yu, Antoine Weihs, Anselm Hoppmann, Franziska Grundner-Culemann, Josine L. Min, Victoria L. Halperin Kuhns, Adebowale A. Adeyemo, Charles Agyemang, Johan Ärnlöv, Nasir A. Aziz, Andrea Baccarelli, Murielle Bochud, Hermann Brenner, Jan Bressler, Monique M. B. Breteler, Cristian Carmeli, Layal Chaker, Josef Coresh, Tanguy Corre, Adolfo Correa, Simon R. Cox, Graciela E. Delgado, Kai-Uwe Eckardt, Arif B. Ekici, Karlhans Endlich, James S. Floyd, Eliza Fraszczyk, Xu Gao, Xīn Gào, Allan C. Gelber, Mohsen Ghanbari, Sahar Ghasemi, Christian Gieger, Philip Greenland, Megan L. Grove, Sarah E. Harris, Gibran Hemani, Peter Henneman, Christian Herder, Steve Horvath, Lifang Hou, Mikko A. Hurme, Shih-Jen Hwang, Sharon L. R. Kardia, Silva Kasela, Marcus E. Kleber, Wolfgang Koenig, Jaspal S. Kooner, Florian Kronenberg, Brigitte Kühnel, Christine Ladd-Acosta, Terho Lehtimäki, Lars Lind, Dan Liu, Donald M. Lloyd-Jones, Stefan Lorkowski, Ake T. Lu, Riccardo E. Marioni, Winfried März, Daniel L. McCartney, Karlijn A. C. Meeks, Lili Milani, Pashupati P. Mishra, Matthias Nauck, Christoph Nowak, Annette Peters, Holger Prokisch, Bruce M. Psaty, Olli T. Raitakari, Scott M. Ratliff, Alex P. Reiner, Ben Schöttker, Joel Schwartz, Sanaz Sedaghat, Jennifer A. Smith, Nona Sotoodehnia, Hannah R. Stocker, Silvia Stringhini, Johan Sundström, Brenton R. Swenson, Joyce B. J. van Meurs, Jana V. van Vliet-Ostaptchouk, Andrea Venema, Uwe Völker, Juliane Winkelmann, Bruce H. R. Wolffenbuttel, Wei Zhao, Yinan Zheng, The Estonian Biobank Research Team, The Genetics of DNA Methylation Consortium, Marie Loh, Harold Snieder, Melanie Waldenberger, Daniel Levy, Shreeram Akilesh, Owen M. Woodward, Katalin Susztak, Alexander Teumer, Anna Köttgen

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Serum urate concentration can be studied in large datasets to find genetic and epigenetic loci that may be related to cardiometabolic traits. Here the authors identify and replicate 100 urate-associated CpGs, which provide insights into urate GWAS lo

Externí odkaz: https://doaj.org/article/34e5ed6ae9ad4343931586438a0971b4

Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome

Autor: Eleonora Porcu, Marie C. Sadler, Kaido Lepik, Chiara Auwerx, Andrew R. Wood, Antoine Weihs, Maroun S. Bou Sleiman, Diogo M. Ribeiro, Stefania Bandinelli, Toshiko Tanaka, Matthias Nauck, Uwe Völker, Olivier Delaneau, Andres Metspalu, Alexander Teumer, Timothy Frayling, Federico A. Santoni, Alexandre Reymond, Zoltán Kutalik

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

Identification of gene expression changes between healthy and diseased individuals can reveal mechanistic insights and biomarkers. Here, the authors propose a bi-directional transcriptome-wide Mendelian Randomization approach to assess causal effects

Externí odkaz: https://doaj.org/article/b6ea07fec9aa4a9aa84d8abbe352d3b1

Epigenome-wide association study reveals CpG sites associated with thyroid function and regulatory effects on KLF9

Autor: Antoine Weihs, Layal Chaker, Tiphaine C. Martin, Kim V.E. Braun, Purdey J. Campbell, Simon R. Cox, Myriam Fornage, Christian Gieger, Hans J. Grabe, Harald Grallert, Sarah E. Harris, Brigitte Kühnel, Riccardo E. Marioni, Nicholas G. Martin, Daniel L. McCartney, Allan F. McRae, Christa Meisinger, Joyce B.J. van Meurs, Jana Nano, Matthias Nauck, Annette Peters, Holger Prokisch, Michael Roden, Elizabeth Selvin, Marian Beekman, Diana van Heemst, Eline P. Slagboom, Brenton R. Swenson, Adrienne Tin, Pei-Chien Tsai, Andre Uitterlinden, W. Edward Visser, Henry Völzke, Melanie Waldenberger, John P. Walsh, Anna Köttgen, Scott G. Wilson, Robin P. Peeters, Jordana T. Bell, Marco Medici, Alexander Teumer

Publikováno v: Weihs, A, Chaker, L, Martin, T C, Braun, K V E, Campbell, P J, Cox, S R, Fornage, M, Gieger, C, Grabe, H J, Grallert, H, Harris, S, Kuhnel, B, Marioni, R E, Martin, N, McCartney, D L, Mcrae, A F, Meisinger, C, van Meurs, J B J, Nano, J, Nauck, M, Peters, A, Prokisch, H, Roden, M, Selvin, E, Beekman, M, van Heemst, D, Slagboom, P E, Swenson, B R, Tin, A, Tsai, P-C, Uitterlinden, A G, Visser, W E, Völzke, H, Waldenberger, M, Walsh, J P, Köttgen, A, Wilson, S G, Peeters, R P, Bell, J T, Medici, M & Teumer, A 2023, ' Epigenome-wide association study reveals CpG sites associated with thyroid function and regulatory effects on KLF9 ', Thyroid Journal Program, vol. 33, no. 3, pp. 301–311 . https://doi.org/10.1089/thy.2022.0373
Thyroid 33(3), 301-311 (2023). doi:10.1089/thy.2022.0373
Thyroid, 33(3), 301-311. Mary Ann Liebert Inc.

Background: Thyroid hormones play a key role in differentiation and metabolism and are known regulators of gene expression through both genomic and epigenetic processes including DNA methylation. The aim of this study was to examine associations betw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f044dc86f46b10e5975d27cc4a844172
https://hdl.handle.net/20.500.11820/324704c8-f3a4-4bb2-ad94-f9ff5b35fa23

The relationship between Alzheimer's-related brain atrophy patterns and sleep macro-architecture

Autor: Antoine Weihs, Stefan Frenzel, Linda Garvert, Luise Kühn, Katharina Wittfeld, Ralf Ewert, Ingo Fietze, Thomas Penzel, Beate Stubbe, András Szentkirályi, Niklas Wulms, Henry Völzke, Hans J. Grabe

Publikováno v: Alzheimer's & dementia / Diagnosis, assessment & disease monitoring 14(1), e12371 (2022). doi:10.1002/dad2.12371

Sleep is increasingly recognized as a major risk factor for neurodegenerative disorders such as Alzheimer's disease (AD).Using an magnetic resonance imaging (MRI)-based AD score based on clinical data from the Alzheimer's Disease Neuroimaging Initiat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74fbb53df86f0f20a3cf6149beccf99
https://pubmed.ncbi.nlm.nih.gov/36381559