Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Antoine Ménoret"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The search for dementia treatments, including treatments for neuropsychiatric lupus (NPSLE), has not yet uncovered useful therapeutic targets that mitigate underlying inflammation. Currently, NPSLE’s limited treatment options are often acc
Externí odkaz:
https://doaj.org/article/25e88789dddd4480a02f0d67db2b4f57
Autor:
William C. Theune, Ju Chen, Eileen Victoria Theune, Xiaoyang Ye, Antoine Ménoret, Anthony T. Vella, Kepeng Wang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundInterleukin-17 (IL-17) family cytokines promote protective inflammation for pathogen resistance, but also facilitate autoimmunity and tumor development. A direct signal of IL-17 to regulatory T cells (Tregs) has not been reported and may he
Externí odkaz:
https://doaj.org/article/bf87f7da59524d10bc5a24ee0e7274b2
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The provision of costimulatory signals to T cells are known to be vital in the direction and induction of a T cell driven response. Here the authors show an optimal T cell response requires a costimulatory induced modification of the transcript lands
Externí odkaz:
https://doaj.org/article/5f9acd8e70524ef1a3d9a323352fee0e
Autor:
Antoine Ménoret, Federica Agliano, Timofey A. Karginov, Keaton S. Karlinsey, Beiyan Zhou, Anthony T. Vella
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
MicroRNA-150 (miR-150) has been shown to play a general role in the immune system, but very little is known about its role on CD4+ T cell responses. During T cell responses against superantigen Staphylococcal Enterotoxin A, miR-150 expression was dow
Externí odkaz:
https://doaj.org/article/7d33ae2362004c1e8e8efe8f3aca50db
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101441- (2022)
Summary: Studying the metabolic fitness of T cells is fundamental to understand how immune responses are regulated. Here, we describe a step-by-step protocol optimized to efficiently generate and isolate effector antigen-specific CD8+ T cells ex vivo
Externí odkaz:
https://doaj.org/article/51ea0da65d254750b8f783a5161a08e4
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103932- (2022)
Summary: Nicotinamide (NAM) shapes T cell responses but its precise molecular mechanism of action remains elusive. Here, we show that NAM impairs naive T cell effector transition but also effector T cells themselves. Although aerobic glycolysis is a
Externí odkaz:
https://doaj.org/article/5a99e07485554dddb56a445d202a67d2
Autor:
Cory M. Willis, Antoine Ménoret, Evan R. Jellison, Alexandra M. Nicaise, Anthony T. Vella, Stephen J. Crocker
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Astrocytes are the most abundant glial cell type in the central nervous system (CNS) and are known to fulfill critical homeostatic functions. Dysfunction of activated astrocytes is also known to participate in the development of several neurological
Externí odkaz:
https://doaj.org/article/3088d0e62f5e4853b9aee5edc656ea40
Publikováno v:
Toxins, Vol 2, Iss 7, Pp 1898-1912 (2010)
In response to environmental cues the human pathogen Staphylococcus aureus synthesizes and releases proteinaceous enterotoxins. These enterotoxins are natural etiologic entities of severe food poisoning, toxic shock syndrome, and acute diseases. Stap
Externí odkaz:
https://doaj.org/article/dffb9d14f6274db49e389bd563964991
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141548 (2015)
Pathogen and cellular by-products released during infection or trauma are critical for initiating mucosal inflammation. The localization of these factors, their bioactivity and natural countermeasures remain unclear. This concept was studied in mice
Externí odkaz:
https://doaj.org/article/25ef16ae2e52410db1f848cb97151240
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40184 (2012)
Acute lung injury (ALI) is characterized by pulmonary edema and acute inflammation leading to pulmonary dysfunction and potentially death. Early medical intervention may ameliorate the severity of ALI, but unfortunately, there are no reliable biomark
Externí odkaz:
https://doaj.org/article/fdf561bd4f4f450384428ea12e27f1b1