Integrating radiomics into holomics for personalised oncology: from algorithms to bedside

Autor: Roberto Gatta, Adrien Depeursinge, Osman Ratib, Olivier Michielin, Antoine Leimgruber

Publikováno v: European Radiology Experimental, Vol 4, Iss 1, Pp 1-9 (2020)

Abstract Radiomics, artificial intelligence, and deep learning figure amongst recent buzzwords in current medical imaging research and technological development. Analysis of medical big data in assessment and follow-up of personalised treatments has

Externí odkaz: https://doaj.org/article/f0a0754884cf45daa2dd9317afc62c65

Behavior of Endogenous Tumor-Associated Macrophages Assessed In Vivo Using a Functionalized Nanoparticle

Autor: Antoine Leimgruber, Cedric Berger, Virna Cortez-Retamozo, Martin Etzrodt, Andita P. Newton, Peter Waterman, Jose Luiz Figueiredo, Rainer H. Kohler, Natalie Elpek, Thorsten R. Mempel, Filip K. Swirski, Matthias Nahrendorf, Ralph Weissleder, Mikael J. Pittet

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 5, Pp 459-468 (2009)

Tumor-associated macrophages (TAMs) invade the tumor stroma in many cancers, yet their role is incompletely understood. To visualize and better understand these critical cells in tumor progression, we screened a portfolio of rationally selected, inje

Externí odkaz: https://doaj.org/article/f91897bdee8d4dae93dee63ddf5784b3

TCRep 3D: an automated in silico approach to study the structural properties of TCR repertoires.

Autor: Antoine Leimgruber, Mathias Ferber, Melita Irving, Hamid Hussain-Kahn, Sébastien Wieckowski, Laurent Derré, Nathalie Rufer, Vincent Zoete, Olivier Michielin

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e26301 (2011)

TCRep 3D is an automated systematic approach for TCR-peptide-MHC class I structure prediction, based on homology and ab initio modeling. It has been considerably generalized from former studies to be applicable to large repertoires of TCR. First, the

Externí odkaz: https://doaj.org/article/faa0b69c526f44d98ab040d69269f945

Optimized exosome isolation protocol for cell culture supernatant and human plasma

Autor: Christina S. F. Wong, Richard J. Lobb, Melanie Becker, Adrian P. Wiegmans, Andreas Möller, Antoine Leimgruber, Shu Wen Wen

Publikováno v: Journal of Extracellular Vesicles, Vol 4, Iss 0, Pp 1-11 (2015)
Journal of Extracellular Vesicles, vol. 4, pp. 27031
Journal of Extracellular Vesicles
Journal of Extracellular Vesicles; Vol 4 (2015) incl supplements

Extracellular vesicles represent a rich source of novel biomarkers in the diagnosis and prognosis of disease. However, there is currently limited information elucidating the most efficient methods for obtaining high yields of pure exosomes, a subset

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8138b421c92186a5085d2913cfd3d304
http://www.journalofextracellularvesicles.net/index.php/jev/article/view/27031/pdf_11

Effect of Platinum-Based Chemoradiotherapy on Cellular Proliferation in Bone Marrow and Spleen, Estimated by (18)F-FLT PET/CT in Patients with Locally Advanced Non-Small Cell Lung Cancer

Autor: Andreas Möller, Sarah Everitt, David Ball, Benjamin Solomon, Michael MacManus, Marine Chabrot, Antoine Leimgruber, Rodney J. Hicks

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 55(7)

Historically, it has been difficult to monitor the acute impact of anticancer therapies on hematopoietic organs on a whole-body scale. Deeper understanding of the effect of treatments on bone marrow would be of great potential value in the rational d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f42bdc9264b85324d2d96c4584adaf
https://pubmed.ncbi.nlm.nih.gov/24868108