Výsledky vyhledávání - "Antoine Le Griffon"

Two-Directional Approach for the Rapid Synthesis of 2,4-Bis-Aminoaryl Pyridine Derivatives

Autor: Patrick Ple, Antoine Le Griffon, Janet Hawkins, Barlaam Bernard Christophe, Rémy Morgentin, Lorraine A. Hassall, Kevin Michael Foote, Clifford David Jones, Aurélien Péru

Publikováno v: Synthetic Communications. 42:8-24

We have developed two different approaches in parallel to rapidly access 2,4-bis aminoaryl pyridine compounds from a common starting material. The C-4/C-2 approach uses palladium-mediated coupling reactions to sequentially functionalize C-4 and then

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1a182d6fc9891de17adf912970310ff
https://doi.org/10.1080/00397911.2010.520403

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Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers

Publikováno v: Bioorganicmedicinal chemistry letters. 25(22)

Starting from potent inhibitors of PI3Kα having poor general kinase selectivity (e.g., 1 and 2), optimisation of this series led to the identification of 25, a potent inhibitor of PI3Kα (wild type, E545K and H1047R mutations) and PI3Kδ, selective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3402f114ff5f66ecc62524989b91aa9
https://pubmed.ncbi.nlm.nih.gov/26475521

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ChemInform Abstract: Two-Directional Approach for the Rapid Synthesis of 2,4-Bis-aminoaryl Pyridine Derivatives

Autor: Rémy Morgentin, Clifford David Jones, Aurélien Péru, Lorraine A. Hassall, Janet Hawkins, Barlaam Bernard Christophe, Patrick Ple, Kevin Michael Foote, Antoine Le Griffon

Publikováno v: ChemInform. 43

Two different approaches to synthesize 2,4-bis-aminoaryl pyridine derivatives are introduced.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6387c3d2fd691ba7bacf00ee31a3f4a6
https://doi.org/10.1002/chin.201223153

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