Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Antoine H Chaanine"'
Autor:
Donnell White, Lothar Lauterboeck, Parnia Mobasheran, Tetsuya Kitaguchi, Antoine H. Chaanine, Qinglin Yang
Publikováno v:
Cells, Vol 12, Iss 5, p 695 (2023)
Adenosine 5′ triphosphate (ATP) is the energy currency of life, which is produced in mitochondria (~90%) and cytosol (less than 10%). Real-time effects of metabolic changes on cellular ATP dynamics remain indeterminate. Here we report the design an
Externí odkaz:
https://doaj.org/article/26dafbd0c1c44a6d8d2038e88311693c
Autor:
Antoine H. Chaanine, LeeAnn Higgins, Lothar Lauterboeck, Todd Markowski, Qinglin Yang, Patrice Delafontaine
Publikováno v:
Cells, Vol 11, Iss 9, p 1572 (2022)
Previous work showed a role of BNIP3 in myocardial remodeling and progression to HFrEF. We utilized a multiomics approach to unravel BNIP3-related molecular mechanisms in the pathogenesis of HFrEF. BNIP3 knockdown in HFrEF improved glycolysis, pyruva
Externí odkaz:
https://doaj.org/article/5ea7ba24e82744039016eb4a5d23c926
Autor:
Antoine H. Chaanine, LeeAnn Higgins, Todd Markowski, Jarrod Harman, Maureen Kachman, Charles Burant, L. Gabriel Navar, David Busija, Patrice Delafontaine
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 235 (2021)
Metabolic remodeling plays an important role in the pathophysiology of heart failure (HF). We sought to characterize metabolic remodeling and implicated signaling pathways in two rat models of early systolic dysfunction (MOD), and overt systolic HF (
Externí odkaz:
https://doaj.org/article/c3bc29aa09bb4f78935ec1666f0b66c0
Autor:
Antoine H. Chaanine
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10579 (2021)
The heart is an organ with high-energy demands in which the mitochondria are most abundant. They are considered the powerhouse of the cell and occupy a central role in cellular metabolism. The intermyofibrillar mitochondria constitute the majority of
Externí odkaz:
https://doaj.org/article/55300d14fef248aa942a92829b081abc
Autor:
Sireesha Upadhrasta, Abdulrahman Museedi, Tariq Thannoun, Antoine H. Chaanine, Thierry H. Le Jemtel
Publikováno v:
Cardiology in Review.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da2946374d32a206b50b46b21b72865f
https://doi.org/10.1097/crd.0000000000000485
https://doi.org/10.1097/crd.0000000000000485
Autor:
Daniela Urina Jassir, Antoine H. Chaanine, Sapna Desai, Indranee Rajapreyar, Thierry H. Le Jemtel
Publikováno v:
The American journal of medicine. 136(1)
Sepsis is an increasing cause of decompensation in patients with chronic heart failure with reduced or preserved ejection fraction. Sepsis and decompensated heart failure results in a mixed septic-cardiogenic shock that poses several therapeutic dile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4b87be2d49ade65eff6d68243419f1
https://pubmed.ncbi.nlm.nih.gov/36252709
https://pubmed.ncbi.nlm.nih.gov/36252709
Autor:
Antoine H. Chaanine, K Sreekumaran Nair, Robert H. Bergen, Katherine Klaus, Adam J. Guenzel, Roger J. Hajjar, Margaret M. Redfield
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 6 (2017)
BackgroundFollowing pressure overload, compensatory concentric left ventricular remodeling (CR) variably transitions to eccentric remodeling (ER) and systolic dysfunction. Mechanisms responsible for this transition are incompletely understood. Here w
Externí odkaz:
https://doaj.org/article/b94e51f9816d4587874461f7f0be2eb9
Autor:
Antoine H. Chaanine
Publikováno v:
Medicina, Vol 55, Iss 6, p 239 (2019)
Background and objectives: Derangements in mitochondrial integrity and function constitute an important pathophysiological feature in the pathogenesis of heart failure (HF) and play an important role in myocardial remodeling and systolic dysfunction.
Externí odkaz:
https://doaj.org/article/38bd26068d3945fc8559584b594a53c3
Publikováno v:
Journal of Clinical Medicine
The mitochondria are mostly abundant in the heart, a beating organ of high- energy demands. Their function extends beyond being a power plant of the cell including redox balance, ion homeostasis and metabolism. They are dynamic organelles that are te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8a23731b40209f8f82537380be7e4f
https://pubmed.ncbi.nlm.nih.gov/33172082
https://pubmed.ncbi.nlm.nih.gov/33172082
Autor:
Antoine H. Chaanine
Publikováno v:
Journal of the American College of Cardiology. 71:2011-2014
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3de6fa15c8c5df5b9fb80c55172cce38
https://doi.org/10.1016/j.jacc.2018.02.067
https://doi.org/10.1016/j.jacc.2018.02.067