Výsledky vyhledávání - "Antoine Frangeul"

Akademický článek

The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription.

Autor: Benjamin Morin, Bruno Coutard, Michaela Lelke, François Ferron, Romy Kerber, Saïd Jamal, Antoine Frangeul, Cécile Baronti, Rémi Charrel, Xavier de Lamballerie, Clemens Vonrhein, Julien Lescar, Gérard Bricogne, Stephan Günther, Bruno Canard

Publikováno v: PLoS Pathogens, Vol 6, Iss 9, p e1001038 (2010)

Arenaviridae synthesize viral mRNAs using short capped primers presumably acquired from cellular transcripts by a 'cap-snatching' mechanism. Here, we report the crystal structure and functional characterization of the N-terminal 196 residues (NL1) of

Externí odkaz: https://doaj.org/article/876236fd04814573bef8fd4aed21e9a0

Zobrazit plný text záznamu

CXCL7 is a predictive marker of sunitinib efficacy in clear cell renal cell carcinomas

Publikováno v: British Journal of Cancer
British Journal of Cancer, Cancer Research UK, 2017, 117 (7), pp.947-953. ⟨10.1038/bjc.2017.276⟩
British Journal of Cancer, 2017, 117 (7), pp.947-953. ⟨10.1038/bjc.2017.276⟩

Sunitinib is one of the first-line standard treatments for metastatic clear cell renal cell carcinoma (ccRCC) with a median time to progression shorter than 1 year. The objective is to discover predictive markers of response to adapt the treatment at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::853167db6838995384ec5fce7978038a
https://doi.org/10.1038/bjc.2017.276

Zobrazit plný text záznamu

Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues

Autor: Cécile Bussetta, Karine Barral, Bruno Canard, Karine Alvarez, Antoine Frangeul, Jerome Deval

Publikováno v: Antiviral Therapy
Antiviral Therapy, International Medical Press, 2019, 13 (1), pp.115-24
Antiviral Therapy, 2019, 13 (1), pp.115-24

BackgroundIn the treatment of HIV, the loose active site of the HIV-1 reverse transcriptase (RT) allows numerous nucleotide analogues to act as proviral DNA ‘chain-terminators’. Acyclic nucleotide phosphonate analogues (ANPs) represent a particul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7703d381b2c6a6737c63d9c4c54b24a
https://hal-amu.archives-ouvertes.fr/hal-02061712

Zobrazit plný text záznamu

Arenaviruses and hantaviruses: From epidemiology and genomics to antivirals

Autor: Bruno Coutard, Rémi N. Charrel, Antoine Nougairède, Bruno Canard, Saïd Jamal, Boris Klempa, X. de Lamballerie, Cécile Baronti, Christian L. Schmidt, Antoine Frangeul, Benjamin Morin, Rolf Hilgenfeld

Publikováno v: Antiviral Research. 90:102-114

The arenaviruses and hantaviruses are segmented genome RNA viruses that are hosted by rodents. Due to their association with rodents, they are globally widespread and can infect humans via direct or indirect routes of transmission, causing considerab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5acfb6fd06a2ec3552bee7093c6b4456
https://doi.org/10.1016/j.antiviral.2011.02.009

Zobrazit plný text záznamu

In Vitro Suppression of K65R Reverse Transcriptase-Mediated Tenofovir- and Adefovir-5'-Diphosphate Resistance Conferred by the Boranophosphonate Derivatives

Autor: Karine Alvarez, Bruno Canard, Antoine Frangeul, Karine Barral

Publikováno v: Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2007, 51 (9), pp.3162-3167. ⟨10.1128/AAC.00145-07⟩
Antimicrobial Agents and Chemotherapy, 2007, 51 (9), pp.3162-3167. ⟨10.1128/AAC.00145-07⟩

9-[2-(Boranophosphonomethoxy)ethyl]adenine diphosphate (BH3-PMEApp) and (R)-9-[2-(boranophosphonomethoxy)propyl]adenine diphosphate (BH3-PMPApp), described here, represent the first nucleoside phosphonates modified on their α-phosphates that act as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7eaaa8dc7750bc7489f00ed641c11b
https://hal-amu.archives-ouvertes.fr/hal-02061675

Zobrazit plný text záznamu

Structural and Functional Basis for ADP-Ribose and Poly(ADP-Ribose) Binding by Viral Macro Domains

Autor: Christian Cambillau, John Ziebuhr, Marie-Pierre Egloff, Hélène Malet, Arnaud Gruez, Antoine Frangeul, Maarit Heinonen, Tero Ahola, Hélène Dutartre, Valérie Campanacci, Ákos Putics, Bruno Canard

Publikováno v: Journal of Virology
Journal of Virology, American Society for Microbiology, 2006, 80 (17), pp.8493-8502. ⟨10.1128/JVI.00713-06⟩
Journal of Virology, 2006, 80 (17), pp.8493-8502. ⟨10.1128/JVI.00713-06⟩

Macro domains constitute a protein module family found associated with specific histones and proteins involved in chromatin metabolism. In addition, a small number of animal RNA viruses, such as corona- and toroviruses, alphaviruses, and hepatitis E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745ddb77402f3d785ece2d2d0356cad3
https://hal.archives-ouvertes.fr/hal-02459228

Zobrazit plný text záznamu

Bunyaviridae RNA Polymerases (L-protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral Cap-Dependent Transcription

Autor: Clemens Vonrhein, Bruno Coutard, Antoine Frangeul, Bruno Canard, Michaela Lelke, Romy Kerber, Rémi N. Charrel, Cécile Baronti, Saïd Jamal, Xavier de Lamballerie, François Ferron, Gérard Bricogne, Benjamin Morin, Stephan Günther, Julien Lescar

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 6, Iss 9, p e1001038 (2010)

Arenaviridae synthesize viral mRNAs using short capped primers presumably acquired from cellular transcripts by a ‘cap-snatching’ mechanism. Here, we report the crystal structure and functional characterization of the N-terminal 196 residues (NL1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ba28f605c643e4ed46e073eb37b5f2
https://doi.org/10.1371/journal.ppat.1001038

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání