Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Antoine E. Karnoub"'
Publikováno v:
Biomedicines, Vol 12, Iss 10, p 2220 (2024)
Background: Busulfan is an FDA-approved alkylating drug used in the chemotherapy of advanced acute myeloid leukemia. The precise mechanisms by which Busulfan kills spermatogonia stem cells (SSCs) are not yet completely understood. Methods: Using a mu
Externí odkaz:
https://doaj.org/article/86524d65cb2f43f49af7a7b699868d0c
Autor:
Zhenbo Tu, Antoine E. Karnoub
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101413- (2022)
Summary: We provide a protocol for gain-of-function (GOF) cDNA screen of genes that foster cancer cell colonization of secondary tissues, the last and most lethal step of the metastasis cascade. We present techniques for cDNA viral library preparatio
Externí odkaz:
https://doaj.org/article/fd2405b67b364c98934c1f5053042416
Autor:
Zhenbo Tu, Johannes Schmoellerl, Odette Mariani, Yurong Zheng, Yi Hu, Anne Vincent-Salomon, Antoine E. Karnoub
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-13 (2021)
Abstract The development of triple-negative breast cancer (TNBC) is critically regulated by certain tumor-microenvironment-associated cells called mesenchymal stem/stromal cells (MSCs), which we and others have shown promote TNBC progression by activ
Externí odkaz:
https://doaj.org/article/eb5b212410734bcb9411cb9cb050eda5
Autor:
Zhenbo Tu, Shengqi Hou, Yurong Zheng, Maerjianghan Abuduli, Tamer Onder, Andrew M. Intlekofer, Antoine E. Karnoub
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102425- (2021)
Summary: Elucidations of the factors that promote the growth of disseminated tumor cells (DTCs) into life-threatening lesions stand to provide much needed prognostic and therapeutic targets of translational utility for patients with metastatic cancer
Externí odkaz:
https://doaj.org/article/13fec15e8e6a45058adcc4078b3b1155
Autor:
Zhenbo Tu, Antoine E. Karnoub
Publikováno v:
Seminars in Cancer Biology. 86:81-92
Mesenchymal stem/stromal cells (MSCs) encompass a heterogeneous population of fibroblastic progenitor cells that reside in multiple tissues around the body. They are endowed with capacities to differentiate into multiple connective tissue lineages, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39227b97ebd5360dc5999e5814100498
https://doi.org/10.1016/j.semcancer.2022.09.002
https://doi.org/10.1016/j.semcancer.2022.09.002
Autor:
Philippe Clézardin, Marie Brevet, Antoine E. Karnoub, Géraldine Aimond, Clémence Thomas, Floriane Pez, Edith Bonnelye, Martine Croset, Casina Kan, Paola Di Mauro, Laura Ferreras, Caroline Reynaud
Supplementary figure legends from S1 to S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506b681f51e3e63df29d3c1cd4edea61
https://doi.org/10.1158/0008-5472.22411913.v1
https://doi.org/10.1158/0008-5472.22411913.v1
Autor:
Philippe Clézardin, Marie Brevet, Antoine E. Karnoub, Géraldine Aimond, Clémence Thomas, Floriane Pez, Edith Bonnelye, Martine Croset, Casina Kan, Paola Di Mauro, Laura Ferreras, Caroline Reynaud
Supplementary Table S1. Primer pairs used for quantitative real-time PCR analysis. Supplementary Table S2. Summary of the gene expression datasets used for meta-analysis. Supplementary Table S3. Expression levels of LOX-like mRNAs in Hct116 cells tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41cb0f506b1611ac8ebf2bea535cb7aa
https://doi.org/10.1158/0008-5472.22411907.v1
https://doi.org/10.1158/0008-5472.22411907.v1
Autor:
Philippe Clézardin, Marie Brevet, Antoine E. Karnoub, Géraldine Aimond, Clémence Thomas, Floriane Pez, Edith Bonnelye, Martine Croset, Casina Kan, Paola Di Mauro, Laura Ferreras, Caroline Reynaud
Lysyl oxidase (LOX) is a secreted copper-dependent amine oxidase whose primary function is to drive collagen crosslinking and extracellular matrix stiffness. LOX in colorectal cancer synergizes with hypoxia-inducible factor-1 (HIF-1) to promote tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fa6ac9faf7030fa3eb06539061a20c7
https://doi.org/10.1158/0008-5472.c.6508325.v1
https://doi.org/10.1158/0008-5472.c.6508325.v1
Autor:
Philippe Clézardin, Marie Brevet, Antoine E. Karnoub, Géraldine Aimond, Clémence Thomas, Floriane Pez, Edith Bonnelye, Martine Croset, Casina Kan, Paola Di Mauro, Laura Ferreras, Caroline Reynaud
Figure S1: LOX expression and clinical outcomes. Figure S2:The LOX inhibitor βAPN inhibits osteolytic lesion formation in vivo. Figure S3: Measurement of LOX enzymatic activity. Figure S4: Correlation analysis of the expression intensity of LOX and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed28ac88e4401f5ca74264c0790f9bf
https://doi.org/10.1158/0008-5472.22411910.v1
https://doi.org/10.1158/0008-5472.22411910.v1
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The phosphoinositide 3-kinase (PI3K) pathway represents the most hyperactivated oncogenic pathway in triple-negative breast cancer (TNBC), a highly aggressive tumor subtype encompassing ∼15% of breast cancers and which possesses no targeted therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdbcc39c7e0544b1c8d7a23920e4ebdb
https://doi.org/10.1073/pnas.2203180119
https://doi.org/10.1073/pnas.2203180119