Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Antoine E, Roux"'
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Organisms undergo a variety of characteristic changes as they age, suggesting a substantial commonality in the mechanistic basis of aging. Experiments in model organisms have revealed a variety of cellular systems that impact lifespan, but technical
Externí odkaz:
https://doaj.org/article/3d576617ebdd4db1899e581561ab443e
Autor:
Antoine E. Roux, Han Yuan, Katie Podshivalova, David Hendrickson, Rex Kerr, Cynthia Kenyon, David R. Kelley
Here we describe a single-cell atlas of aging for the nematode Caenorhabditis elegans. This unique resource describes the expression across adulthood of over 20,000 genes among 211 groups of cells that correspond to virtually every cell type in this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc262fdd7c0a8f17a871901dca0de44d
https://doi.org/10.1101/2022.06.15.496201
https://doi.org/10.1101/2022.06.15.496201
Publikováno v:
Frontiers in aging. 3
Organisms undergo a variety of characteristic changes as they age, suggesting a substantial commonality in the mechanistic basis of aging. Experiments in model organisms have revealed a variety of cellular systems that impact lifespan, but technical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::616aac4831cca6297cd576b8ac2616cb
https://pubmed.ncbi.nlm.nih.gov/36105851
https://pubmed.ncbi.nlm.nih.gov/36105851
Autor:
Antoine E, Roux, Chunlian, Zhang, Jonathan, Paw, José, Zavala-Solorio, Evangelia, Malahias, Twaritha, Vijay, Ganesh, Kolumam, Cynthia, Kenyon, Jacob C, Kimmel
Publikováno v:
Cell Systems. 13:574-587.e11
Partial pluripotent reprogramming can reverse features of aging in mammalian cells, but the impact on somatic identity and the necessity of individual reprogramming factors remain unknown. Here, we used single-cell genomics to map the identity trajec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55746f560ae2fc2b0b3975296a078911
https://doi.org/10.1016/j.cels.2022.05.002
https://doi.org/10.1016/j.cels.2022.05.002
Autor:
Twaritha Vijay, Jacob C. Kimmel, José-Zavalara Solorio, Ganesh Kolumam, Chunlian Zhang, Antoine E. Roux, Cynthia Kenyon, Jonathan S. Paw
Transient induction of pluripotent reprogramming factors has been reported to reverse some features of aging in mammalian cells and tissues. However, the impact of transient reprogramming on somatic cell identity programs and the necessity of individ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12d890b909f187223879079de81784a6
https://doi.org/10.1101/2021.05.21.444556
https://doi.org/10.1101/2021.05.21.444556
Autor:
Antoine E Roux, Alexandre Leroux, Manal A Alaamery, Charles S Hoffman, Pascal Chartrand, Gerardo Ferbeyre, Luis A Rokeach
Publikováno v:
PLoS Genetics, Vol 5, Iss 3, p e1000408 (2009)
Glucose is the preferred carbon and energy source in prokaryotes, unicellular eukaryotes, and metazoans. However, excess of glucose has been associated with several diseases, including diabetes and the less understood process of aging. On the contrar
Externí odkaz:
https://doaj.org/article/92c7bbee5fc7471198fb000cbff45725
Cells can enter quiescent states in which cell cycling and growth are suspended. We find that during a long developmental arrest (quiescence) induced by starvation, newly hatched C. elegans acquire features associated with impaired proteostasis and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472752d4119b92c61fd00f8634e32734
https://europepmc.org/articles/PMC5794336/
https://europepmc.org/articles/PMC5794336/
Publikováno v:
Annals of the New York Academy of Sciences. 1197:19-27
We present results showing that glucose signaling has proaging effects in the yeast Schizosaccharomyces pombe. Deletion of the receptor that senses extracellular glucose (Git3) increases the life span of S.pombe, while constitutive activation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e565a46f12bb2c6bcba149f1779c211
https://doi.org/10.1111/j.1749-6632.2010.05198.x
https://doi.org/10.1111/j.1749-6632.2010.05198.x
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. :1-8
In the past years, simple organisms such as yeasts and worms have contributed a great deal to aging research. Studies pioneered in Saccharomyces cerevisiae were useful to elucidate a significant number of molecular mechanisms underlying cellular agin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d18a19065b6172e5411cc7397b66f3
https://doi.org/10.1093/gerona/glp152
https://doi.org/10.1093/gerona/glp152
Publikováno v:
Aging Cell. 5:345-357
Budding yeast shows a progressive decline in viability after entering stationary phase, a phenomenon known as chronological aging. We show here that the fission yeast Schizosaccharomyces pombe also undergoes chronological aging and that the process i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b24a06dcf0512fe3e4f0fbf983f31dc
https://doi.org/10.1111/j.1474-9726.2006.00225.x
https://doi.org/10.1111/j.1474-9726.2006.00225.x