Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Antoine Désilets"'
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273825 (2022)
TMPRSS6 is a type II transmembrane serine protease involved in iron homeostasis expressed as 4 isoforms in humans. TMPRSS6 isoform 2 downregulates hepcidin production by cleaving hemojuvelin and other surface proteins of hepatocytes. The functions of
Externí odkaz:
https://doaj.org/article/59be08b264514d2e81747bc264b43c0a
Autor:
Kelcie A Lahey, Natalie J Ronaghan, Judie Shang, Sébastien P Dion, Antoine Désilets, Richard Leduc, Wallace K MacNaughton
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180259 (2017)
Changes in barrier function of the gastrointestinal tract are thought to contribute to the inflammatory bowel diseases Crohn's disease and ulcerative colitis. Previous work in our lab demonstrated that apical exposure of intestinal epithelial cell li
Externí odkaz:
https://doaj.org/article/b44bc67df142412d959c2b40a2030a9f
Autor:
Tirosh Shapira, I. Abrrey Monreal, Sébastien P. Dion, David W. Buchholz, Brian Imbiakha, Andrea D. Olmstead, Mason Jager, Antoine Désilets, Guang Gao, Mathias Martins, Thierry Vandal, Connor A. H. Thompson, Aaleigha Chin, William D. Rees, Theodore Steiner, Ivan Robert Nabi, Eric Marsault, Julie Sahler, Diego G. Diel, Gerlinde R. Van de Walle, Avery August, Gary R. Whittaker, Pierre-Luc Boudreault, Richard Leduc, Hector C. Aguilar, François Jean
Publikováno v:
Nature. 605:340-348
The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced owing to emerging variants of concern1,2. Development of host-directed thera
Autor:
Arielle Elkrief, Eder Orlando Méndez-Salazar, Jade Maillou, Chad M. Vanderbilt, Pooja Gogia, Antoine Desilets, Meriem Messaoudene, Daniel Kelly, Marc Ladanyi, Matthew D. Hellmann, Laurence Zitvogel, Charles M. Rudin, Bertrand Routy, Lisa Derosa, Adam J. Schoenfeld
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-9 (2024)
Abstract Anti-PD(L)-1 inhibition combined with platinum doublet chemotherapy (Chemo-IO) has become the most frequently used standard of care regimen in patients with non-small cell lung cancer (NSCLC). The negative impact of antibiotics on clinical o
Externí odkaz:
https://doaj.org/article/6b78137517bb4690816d94fa12584591
Autor:
Sébastien P. Dion, Alexandre Murza, Pierre-Luc Boudreault, Eric Marsault, Richard Leduc, Antoine Désilets
Publikováno v:
Expert Opinion on Therapeutic Patents
Type II transmembrane serine proteases (TTSPs) of the human respiratory tract generate high interest owing to their ability, among other roles, to cleave surface proteins of respiratory viruses. This step is critical in the viral invasion of coronavi
Autor:
François Béliveau, Christine Lavoie, Richard Leduc, Antoine Désilets, Cloé Fontaine-Carbonneau, Andréanne Laniel, Erwan Lanchec
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
The amyloid beta peptide (Aβ) is derived from the amyloid precursor protein (APP) by secretase processing. APP is also cleaved by numerous other proteases, such as the type II transmembrane serine protease matriptase, with consequences on the produc
Autor:
Theodore S. Steiner, Guang Gao, Brian Imbiakha, Aaleigha Chin, Sébastien P. Dion, Julie Sahler, Eric Marsault, Ivan R. Nabi, Avery August, François Jean, I. Abrrey Monreal, Hector C. Aguilar, Antoine Désilets, Andrea D. Olmstead, David W. Buchholz, Gerlinde R. Van de Walle, Pierre-Luc Boudreault, Richard Leduc, Mason Jager, William Rees, Tirosh Shapira, Gary R. Whittaker, Thierry Vandal
Publikováno v:
bioRxiv
SummaryThe COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced against emerging variants of concern (VOCs) 1,2. Development of host-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1797ed55d168713c66471069b5fddec
https://europepmc.org/articles/PMC8109206/
https://europepmc.org/articles/PMC8109206/
Autor:
François Béliveau, Antoine Désilets, Mariana Gabriela Ghinet, Sébastien P. Dion, Richard Leduc
Publikováno v:
Journal of Cellular and Molecular Medicine
TMPRSS6 (matriptase‐2) is a type II transmembrane serine protease involved in iron homoeostasis. At the cell surface of hepatocytes, TMPRSS6 cleaves haemojuvelin (HJV) and regulates the BMP/SMAD signalling pathway leading to production of hepcidin,
Autor:
Raza S. Zaheer, Jerrold R. Turner, Natalie Ronaghan, Pina Colarusso, Richard Leduc, Wallace K. MacNaughton, Judie Shang, Antoine Désilets, Vadim Iablokov, Sébastien P. Dion
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 311:G466-G479
Barrier dysfunction is a characteristic of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. Understanding how the tight junction is modified to maintain barrier function may provide avenues for treatment of IBD. We have
Autor:
Antoine Desilets, Alan L Ho
Publikováno v:
BMJ Oncology, Vol 2, Iss 1 (2023)
Externí odkaz:
https://doaj.org/article/8e86894ad91041b8b40e1929c290edd7