Coxsackievirus-B4 Infection Can Induce the Expression of Human Endogenous Retrovirus W in Primary Cells

Autor: Arthur Dechaumes, Antoine Bertin, Famara Sane, Sandrine Levet, Jennifer Varghese, Benjamin Charvet, Valéry Gmyr, Julie Kerr-Conte, Justine Pierquin, Govindakarnavar Arunkumar, François Pattou, Hervé Perron, Didier Hober

Publikováno v: Microorganisms, Vol 8, Iss 9, p 1335 (2020)

Human Endogenous Retrovirus W Envelope (HERV-W ENV) mRNA or protein can be found in peripheral blood mononuclear cells (PBMCs) and exocrine pancreas of patients with type 1 diabetes (T1D). Further, previous observations have shown an association betw

Externí odkaz: https://doaj.org/article/281aac67223a44559e49a4644f11bd49

Emergence of Fluoxetine-Resistant Variants during Treatment of Human Pancreatic Cell Cultures Persistently Infected with Coxsackievirus B4

Autor: Enagnon Kazali Alidjinou, Antoine Bertin, Famara Sane, Delphine Caloone, Ilka Engelmann, Didier Hober

Publikováno v: Viruses, Vol 11, Iss 6, p 486 (2019)

This study reports the antiviral activity of the drug fluoxetine against some enteroviruses (EV). We had previously established a model of persistent coxsackievirus B4 (CVB4) infection in pancreatic cell cultures and demonstrated that fluoxetine coul

Externí odkaz: https://doaj.org/article/bf74a6727e534d7a86b719be9abd1383

Persistence of Coxsackievirus B4 in Pancreatic β Cells Disturbs Insulin Maturation, Pattern of Cellular Proteins, and DNA Methylation

Autor: Enagnon Kazali Alidjinou, Antoine Bertin, Famara Sane, Jean-Pascal Gimeno, Isabelle Fournier, Michel Salzet, Magloire Pandoua Nekoua, Didier Hober, Ilka Engelmann

Publikováno v: Microorganisms
Volume 9
Issue 6
Microorganisms, Vol 9, Iss 1125, p 1125 (2021)
Microorganisms, 2021, Microorganisms, 9 (6), pp.1125. ⟨10.3390/microorganisms9061125⟩

Coxsackievirus-B4 (CV-B4) can persist in pancreatic cell lines and impair the phenoytpe and/or gene expressions in these cells
however, the models used to study this phenomenon did not produce insulin. Therefore, we investigated CV-B4 persistenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c784c0c3139e354ffa3fb168fab066a
https://pubmed.ncbi.nlm.nih.gov/34067388

Persistent coxsackievirus B4 infection induces microRNA dysregulation in human pancreatic cells

Autor: Johann Bossu, Enagnon Kazali Alidjinou, Antoine Bertin, Famara Sane, Ilka Engelmann, Martin Figeac, Céline Villenet, Didier Hober

Publikováno v: Cellular and Molecular Life Sciences. 74:3851-3861

Enterovirus infections are implicated in the development of type 1 diabetes (T1D). MicroRNAs as regulators of gene expression are involved in many physiological and pathological processes. Given that viral infections dysregulate cellular microRNAs, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed717a50440fd59c1f53199201782f7e
https://doi.org/10.1007/s00018-017-2567-0

Impact of coxsackievirus-B4E2 combined with a single low dose of streptozotocin on pancreas of outbred mice: investigation of viral load, pathology and inflammation

Autor: Mehdi A. Benkahla, Famara Sane, Antoine Bertin, Anais-Camille Vreulx, Firas Elmastour, Hela Jaidane, Rachel Desailloud, Didier Hober

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)

Coxsackieviruses B (CV-B) belong to the EV-B species. CV-B and particularly CV-B4 are thought to be involved in the development of chronic diseases like type 1 diabetes (T1D). The mechanisms of the enteroviral pathogenesis of T1D are not well known,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8c2b1ede955bab3250b46c5784b90d44
http://europepmc.org/articles/PMC6626040