Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Antoine Attinger"'
Autor:
Carsten Riether, Andres McAllister, Murali Ramachandra, Frédéric Massière, Yogeshwar Bachhav, Stefania Rigotti, Michel Aguet, Saumitra Sengupta, Yara Banz, Christian M. Schürch, Anne-Laure Huguenin, Anne Vaslin Chessex, Antoine Attinger, Ramin Radpour, Maximilien Murone
Figure S1 shows expression of nuclear pSTAT3 and pSTAT5 in BM of newly diagnosed AML patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085c4f1eaae40f847030bef60ef73b67
https://doi.org/10.1158/1535-7163.22507858.v1
https://doi.org/10.1158/1535-7163.22507858.v1
Autor:
Carsten Riether, Andres McAllister, Murali Ramachandra, Frédéric Massière, Yogeshwar Bachhav, Stefania Rigotti, Michel Aguet, Saumitra Sengupta, Yara Banz, Christian M. Schürch, Anne-Laure Huguenin, Anne Vaslin Chessex, Antoine Attinger, Ramin Radpour, Maximilien Murone
Figure S8 shows that the body weight of AML-bearing mice is not affected by Debio 0617B.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f3734b947f9a9335a62988876c81b3
https://doi.org/10.1158/1535-7163.22507837
https://doi.org/10.1158/1535-7163.22507837
Autor:
Carsten Riether, Andres McAllister, Murali Ramachandra, Frédéric Massière, Yogeshwar Bachhav, Stefania Rigotti, Michel Aguet, Saumitra Sengupta, Yara Banz, Christian M. Schürch, Anne-Laure Huguenin, Anne Vaslin Chessex, Antoine Attinger, Ramin Radpour, Maximilien Murone
Figure S4 shows the pharmacokinetics/pharmacodynamics (PK/PD) of Debio 0617B in the rat MV-4-11 AML model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc480c8b61b49203b4a1b31362ea3d8
https://doi.org/10.1158/1535-7163.22507849.v1
https://doi.org/10.1158/1535-7163.22507849.v1
Autor:
Andres McAllister, Murali Ramachandra, Faye M. Johnson, Courtney Nicholas, Olivier Michielin, Vincent Zoete, Michel Aguet, Marc Lang, Peter Traxler, Silvano Brienza, Yogeshwar Bachhav, Stefania Rigotti, Samiulla Dhodheri, Sivapriya Marappan, Saumitra Sengupta, Girish Daginakatte, Shankar J. Shetty, Raghuveer Ramachandra, Antoine Attinger, Anne Vaslin Chessex, Maximilien Murone
Legend for Supplementary Tables:1,2,3,4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ca53742a30df58de5c8e279ec0d7a6
https://doi.org/10.1158/1535-7163.22503606
https://doi.org/10.1158/1535-7163.22503606
Autor:
Carsten Riether, Andres McAllister, Murali Ramachandra, Frédéric Massière, Yogeshwar Bachhav, Stefania Rigotti, Michel Aguet, Saumitra Sengupta, Yara Banz, Christian M. Schürch, Anne-Laure Huguenin, Anne Vaslin Chessex, Antoine Attinger, Ramin Radpour, Maximilien Murone
Figure S3 shows response of MOLM-13 cells to Debio 0617B after silencing of STAT3 and STAT5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d1ae1b1d98d8aa3c6bba559643e325
https://doi.org/10.1158/1535-7163.22507852
https://doi.org/10.1158/1535-7163.22507852
Autor:
Carsten Riether, Andres McAllister, Murali Ramachandra, Frédéric Massière, Yogeshwar Bachhav, Stefania Rigotti, Michel Aguet, Saumitra Sengupta, Yara Banz, Christian M. Schürch, Anne-Laure Huguenin, Anne Vaslin Chessex, Antoine Attinger, Ramin Radpour, Maximilien Murone
Figure S9 shows that Debio 0617B reduces spleen weight and cellularity in human PDX AML mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010bcbf26d716ba14c644d100a48a480
https://doi.org/10.1158/1535-7163.22507834
https://doi.org/10.1158/1535-7163.22507834
Autor:
Carsten Riether, Andres McAllister, Murali Ramachandra, Frédéric Massière, Yogeshwar Bachhav, Stefania Rigotti, Michel Aguet, Saumitra Sengupta, Yara Banz, Christian M. Schürch, Anne-Laure Huguenin, Anne Vaslin Chessex, Antoine Attinger, Ramin Radpour, Maximilien Murone
Tables S1-S4 show patient characteristics, kinome scan for Debio 0617B, selectivitly profile, GI50 values and FLT3-ITD inhibition capacity of Debio 0617B.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3e4a26353b550d404e1c83d2c611c1
https://doi.org/10.1158/1535-7163.22507828.v1
https://doi.org/10.1158/1535-7163.22507828.v1
Autor:
Carsten Riether, Andres McAllister, Murali Ramachandra, Frédéric Massière, Yogeshwar Bachhav, Stefania Rigotti, Michel Aguet, Saumitra Sengupta, Yara Banz, Christian M. Schürch, Anne-Laure Huguenin, Anne Vaslin Chessex, Antoine Attinger, Ramin Radpour, Maximilien Murone
Figure S2 shows Debio 0617B-induced apoptosis of the FLT3-ITD-driven AML cell line MOLM-13.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107ea7663be13f5692be8c8fc0d5c8fa
https://doi.org/10.1158/1535-7163.22507855.v1
https://doi.org/10.1158/1535-7163.22507855.v1
Autor:
Andres McAllister, Murali Ramachandra, Faye M. Johnson, Courtney Nicholas, Olivier Michielin, Vincent Zoete, Michel Aguet, Marc Lang, Peter Traxler, Silvano Brienza, Yogeshwar Bachhav, Stefania Rigotti, Samiulla Dhodheri, Sivapriya Marappan, Saumitra Sengupta, Girish Daginakatte, Shankar J. Shetty, Raghuveer Ramachandra, Antoine Attinger, Anne Vaslin Chessex, Maximilien Murone
Suppl. Table 1. Binding mode of Debio 0617B to ABL. Suppl. Table 2. Physico-chemical and early ADME profile of Debio 0617B. Suppl. Table 3. Debio 0617B activity on a panel of 21 cancer cell lines. Suppl. Table 4. PK/PD Profile of Debio 0617B in mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10dfcd8f345331fe23adf2ab75896daa
https://doi.org/10.1158/1535-7163.22503609.v1
https://doi.org/10.1158/1535-7163.22503609.v1
Autor:
Carsten Riether, Andres McAllister, Murali Ramachandra, Frédéric Massière, Yogeshwar Bachhav, Stefania Rigotti, Michel Aguet, Saumitra Sengupta, Yara Banz, Christian M. Schürch, Anne-Laure Huguenin, Anne Vaslin Chessex, Antoine Attinger, Ramin Radpour, Maximilien Murone
Acute myelogenous leukemia (AML) is initiated and maintained by leukemia stem cells (LSC). LSCs are therapy-resistant, cause relapse, and represent a major obstacle for the cure of AML. Resistance to therapy is often mediated by aberrant tyrosine kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c54c28b1593658b4b015cece7abf69
https://doi.org/10.1158/1535-7163.c.6538804
https://doi.org/10.1158/1535-7163.c.6538804