Assessment of adeno-associated virus gene therapies efficacy on acid alpha-glucosidase restoration and glycogen storage correction in cardiac muscle of Pompe disease mice using synchrotron infrared and ultraviolet microspectroscopies

Autor: Laurence Dubreil, Lydie Lagalice, Johan Deniaud, Antoine Sabourin, Claire Lovo, Karim Bey, Juliette Hordeaux, Chantal Thorin, Christophe Sandt, Frédéric Jamme, Marie-Anne Colle

Publikováno v: Journal of Spectral Imaging, Vol 8, Iss 1, p a13 (2019)

Pompe disease (glycogen storage disease type II) is a lysosomal storage disorder due to a mutation in the gene that encodes acid alpha-glucosidase (GAA). GAA deficiency causes the excessive storage of lysosomal glycogen in many cell types, leading to

Externí odkaz: https://doaj.org/article/c43b1b00ac0642fcaaad362ed97e6ee1

March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation

Autor: Osama A. Kishta, Antoine Sabourin, Leora Simon, Toby McGovern, Maxime Raymond, Tristan Galbas, Abdelilah Majdoubi, Satoshi Ishido, James G. Martin, Jacques Thibodeau

Publikováno v: Journal of Immunology Research, Vol 2018 (2018)

Membrane-associated RING-CH-1 (March1) is a member of the March family of E3 ubiquitin ligases. March1 downregulates cell surface expression of MHC II and CD86 by targeting them to lysosomal degradation. Given the key roles of MHC class II and CD86 i

Externí odkaz: https://doaj.org/article/f4d7a20688454d35a71b3a38a55e39c3

Uneven genotypic diversity of Escherichia coli in fecal sources limits the performance of a library-dependent method of microbial source tracking on the southwestern French Atlantic coast

Autor: Line Mornet, Frédéric Garabetian, Adeline Jouanillou, Isabelle Vitte, Antoine Sabourin, Hélène Moussard, Mélanie Lesne, Emilie Lyautey

Publikováno v: Canadian Journal of Microbiology
Canadian Journal of Microbiology, NRC Research Press, 2020, 66 (12), pp.698-712. ⟨10.1139/cjm-2020-0244⟩

To develop a library-dependent method of tracking fecal sources of contamination of beaches on the Atlantic coast of southwestern France, a library of 6368 Escherichia coli isolates was constructed from samples of feces, from 40 known human or animal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29bbde0ac7b9c6be4318b0519a4e2601
https://hal.archives-ouvertes.fr/hal-03031235

March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation

Autor: Antoine Sabourin, Satoshi Ishido, Leora Simon, Tristan Galbas, Osama A Kishta, James G. Martin, Abdelilah Majdoubi, Maxime Raymond, Toby K. McGovern, Jacques Thibodeau

Publikováno v: Journal of Immunology Research
Journal of Immunology Research, Vol 2018 (2018)

Membrane-associated RING-CH-1 (March1) is a member of the March family of E3 ubiquitin ligases. March1 downregulates cell surface expression of MHC II and CD86 by targeting them to lysosomal degradation. Given the key roles of MHC class II and CD86 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6e568b8beda7f4676d6405e7b7889d
https://doi.org/10.1155/2018/3823910

Assessment of adeno-associated virus gene therapies efficacy on acid alpha-glucosidase restoration and glycogenstorage correction in cardiac muscle of Pompe disease mice using synchrotron infrared and ultravioletmicrospectroscopies

Autor: Lydie Lagalice, Juliette Hordeaux, Christophe Sandt, Chantal Thorin, Laurence Dubreil, Marie-Anne Colle, Johan Deniaud, Claire Lovo, Frédéric Jamme, Antoine Sabourin, Karim Bey

Publikováno v: Journal of Spectral Imaging
Journal of Spectral Imaging, IM Publications, 2019, ⟨10.1255/jsi.2019.a13⟩
Journal of Spectral Imaging, Vol 8, Iss 1, p a13 (2019)

Pompe disease (glycogen storage disease type II) is a lysosomal storage disorder due to a mutation in the gene that encodes acid alpha-glucosidase (GAA). GAA deficiency causes the excessive storage of lysosomal glycogen in many cell types, leading to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db1ecd34aa714540a47c6dad3230eb9
https://hal.archives-ouvertes.fr/hal-02278997