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Autor:
Antje de la Haye, Michael Gütschow, Katja Sterz, Michael Wiese, Hans-Georg Häcker, Gregor Schnakenburg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6102-6105
P-glycoprotein (P-gp) is an important factor in the development of multidrug resistance (MDR) in cancer cells. In literature reports, a thieno[2,3-d]pyrimidine (QB13) was described as P-gp modulator and opposed effects on the cell accumulation of dis