Supplementary Figures 1 - 3, Tables 1 - 2 from Preclinical Optimization of MDM2 Antagonist Scheduling for Cancer Treatment by Using a Model-Based Approach

Autor: Kathryn Packman, Lyubomir Vassilev, David Heimbrook, Christophe Meille, Michael Linn, Rosario Garrido, Violeta Adames, Shahid Tannu, Kenneth Kolinsky, Edmund Lee, Sazzad Hussain, Zoran Filipovic, Christian Tovar, Antje Walz, Kelli Glenn, Brian Higgins

PDF file - 311KB, Table S1. Results of proliferation assay. Table S2. Estimated PKPD population parameters. Fig. S1. Schematic view of the PK/PD model. Fig S2. Observed PK parameter and model predicted. Fig S3. Visual predictive check.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03937509c03c999ff11b402c64c3a3e1
https://doi.org/10.1158/1078-0432.22456187

Micro-organospheres retain patient tumor microenvironment for precision immuno-oncology

Autor: Shengli Ding, Naveen R. Natesh, Kassandra Spiller, Rui Xi, Daniel Nelson, Nikolche Gjorevski, Antje Walz, Estelle Marrer-Berger, Hans Clevers, Shiaowen David Hsu, Xiling Shen

Publikováno v: Journal of Clinical Oncology. 40:2573-2573

2573 Background: Current patient-derived organoid (PDO) models are largely devoid of immune components. We developed a precision microfluidic and membrane platform to generate patient-derived micro-organospheres (MOS) that retain tumor-resident immun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b6d67b190a283cadc8b45f9c585efa2
https://doi.org/10.1200/jco.2022.40.16_suppl.2573

Translational PK/PD modeling to increase probability of success in drug discovery and early development

Autor: Antje Walz, Antonello Caruso, Thierry Lavé, Neil Parrott

Publikováno v: Drug Discovery Today: Technologies. :27-34

In this review we present ways in which translational PK/PD modeling can address opportunities to enhance probability of success in drug discovery and early development. This is achieved by impacting efficacy and safety-driven attrition rates, throug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a29553af9a25a64d9e5e2d23d17eaa
https://doi.org/10.1016/j.ddtec.2016.11.005

Model-based assessment of erlotinib effect in vitro measured by real-time cell analysis

Autor: Elina Pietilae, Thierry Lavé, Isabelle Walter, Adrian Roth, Stefan Kustermann, Nicole A. Kratochwil, Athanassios Iliadis, Christophe Meille, Antje Walz, Stephan Benay, P. Alexis Gonsard

Publikováno v: Journal of Pharmacokinetics and Pharmacodynamics. 42:275-285

Real time cell analysis (RTCA) is an impedance-based technology which tracks various living cell characteristics over time, such as their number, morphology or adhesion to the extra cellular matrix. However, there is no consensus about how RTCA data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3695c62a25ed11f63697d67949ff7ffb
https://doi.org/10.1007/s10928-015-9415-3

First-in-human phase I clinical trial of RG7356, an anti-CD44 humanized antibody, in patients with advanced, CD44-expressing solid tumors

Autor: Dominik Rüttinger, Florian Heil, Randolph Christen, Christophe Le Tourneau, Devalingam Mahalingam, Michael Brewster, Antje Walz, C. Willemien Menke-van der Houven van Oordt, Michael A. Cannarile, Tapan K. Nayak, Ernesto Guarin, Valerie Meresse, Henk M.W. Verheul, Winette T. A. van der Graaf, Carlos Gomez-Roca, Stefan Weigand, Carla M.L. van Herpen, Andrew L. Coveler

Publikováno v: Menke, C W, Gomez-Roca, C, van Herpen, C, Coveler, A L, Mahalingam, D, Verheul, H M W, van der Graaf, W T A, Christen, R, Ruettinger, D, Weigand, S, Cannarile, M A, Heil, F, Brewster, M, Walz, A-C, Nayak, T K, Guarin, E, Meresse, V & Le Tourneau, C 2016, ' First-in-human phase I clinical trial of RG7356, an anti-CD44 humanized antibody, in patients with advanced, CD44-expressing solid tumors ', Oncotarget, vol. 7, no. 48, pp. 80046-80058 . https://doi.org/10.18632/oncotarget.11098
Oncotarget
Oncotarget, 7(48), 80046-80058. Impact Journals

// C. Willemien Menke-van der Houven van Oordt 1 , Carlos Gomez-Roca 2 , Carla van Herpen 3 , Andrew L. Coveler 4 , Devalingam Mahalingam 5 , Henk M. W. Verheul 1 , Winette T. A. van der Graaf 3 , Randolph Christen 6 , Dominik Ruttinger 7 , Stefan We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e2b3d48416f0e6edb2768480044066
https://research.vumc.nl/en/publications/ccfdebc6-56b5-4554-85b2-67217b7dd862