Výsledky vyhledávání - "Antje Siegert"

Abstract 4674: Patient-derived xenograft (PDX) and corresponding cell line models from glioblastoma for drug development, immuno-oncology and translational research

Autor: Joshua Alcaniz, Lars Winkler, Maria Stecklum, Hagen Wieland, Antje Siegert, Michael Becker, Bernadette Brzezicha, Wolfgang Walther, Jens Hoffmann

Publikováno v: Cancer Research. 83:4674-4674

Background: Glioblastoma (GBM) is the most common malignant brain tumor in adults, with about 90% of tumors developing de novo. Their heterogeneity, aggressiveness and infiltrative growth limit success of current standard of care (SoC) therapy and ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b161c19b00623338565994bf79fdabd4
https://doi.org/10.1158/1538-7445.am2023-4674

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Abstract 5631: Leukaemia and lymphoma patient-derived xenografts (PDX) engraft on humanized mice and respond to immune therapy with check point inhibitors

Autor: Jens Hoffmann, Antje Siegert, Annika Wulf-Goldenberg, Wolfgang Walther, Maria Stecklum, Bernadette Brzezicha, Anja Sterner-Kock

Publikováno v: Cancer Research. 80:5631-5631

Background The preclinical evaluation of novel immune therapies for cancer remains a challenge, as models require both, engraftment of human tumor cells and a matching human immune cell population. In previous experiments, we have demonstrated, that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85a986632f4ab51f301685db650021ad
https://doi.org/10.1158/1538-7445.am2020-5631

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Cell differentiation mediated by co-culture of human umbilical cord blood stem cells with murine hepatic cells

Autor: Maria Stecklum, Annika Wulf-Goldenberg, Klaus Eckert, Iduna Fichtner, Bettina Purfürst, Marlen Keil, Antje Siegert

Publikováno v: In Vitro Cellular & Developmental Biology - Animal. 51:183-191

In the present study, purified human cord blood stem cells were co-cultivated with murine hepatic alpha mouse liver 12 (AML12) cells to compare the effect on endodermal stem cell differentiation by either direct cell-cell interaction or by soluble fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f166daa475b41e5d02395a8ec3d0bba5
https://doi.org/10.1007/s11626-014-9817-3

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Abstract 1040: Patient derived xenografts of hematologic malignancies for translational research

Autor: Martin Janz, Leonid Karawajew, Jens Hoffmann, Antje Siegert, Clemens A. Schmitt, Bernadette Brzezicha, Iduna Fichtner, Stephan Fuhrmann

Publikováno v: Cancer Research. 78:1040-1040

Acute leukemias and lymphomas represent a very heterogeneous group of hematologic malignancies and pose an important challenge in the clinical routine. They frequently develop resistance to the treatment with standard-of-care (SoC) drugs and have a h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ceab52ffd8a9865650530ef0c552399
https://doi.org/10.1158/1538-7445.am2018-1040

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Abstract A005: Drug screening in patient-derived xenografts from acute myeloic leukemia and non-Hodgkin's lymphoma shows correlation with chemotherapy resistance in patients

Autor: Iduna Fichtner, Bernadette Brzezicha, Martin Janz, Jens Hoffmann, Clemens A. Schmitt, Wolfgang Walther, Antje Siegert, Leonid Karawajew

Publikováno v: Molecular Cancer Therapeutics. 17:A005-A005

Non-Hodgkin's lymphomas (NHL) and acute myeloid leukemias (AML) initially respond to chemo- or biologic therapy; however, some develop resistance, becoming aggressively growing tumors. The purpose of our study was the establishment of new PDX models

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8475b799c756fad4db0be887d998acf
https://doi.org/10.1158/1535-7163.targ-17-a005

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Induction of G0/G1 cell cycle arrest in ovarian carcinoma cells by the anti-inflammatory drug NS-398, but not by COX-2-specific RNA interference

Autor: Antje Siegert, Carsten Denkert, Ines Koch, Wilko Weichert, Steffen Hauptmann, Martin Köbel, Peter T. Daniel, Antje Fürstenberg

Publikováno v: Oncogene. 22:8653-8661

Cyclooxygenases, particularly COX-2, play an important role in tumor development and progression. We have previously shown that COX-2 expression is an independent prognostic factor in human ovarian carcinoma. In this study, we investigated the effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910518a479900ef112feb3401acb51ac
https://doi.org/10.1038/sj.onc.1206920

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Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma

Autor: Antje Siegert, Glen Kristiansen, Carsten Denkert, Sören Pest, Hans Guski, B. M. Müller, Steffen Hauptmann, Angela Reles, Wilko Weichert, Klaus-Jürgen Winzer, Martin Köbel

Publikováno v: Cancer. 97:2978-2987

BACKGROUND Cyclooxygenases regulate the production of prostaglandins and play a role in tumor development and progression. The authors investigated the prognostic impact of expression of the cyclooxygenase (COX) isoforms, COX-1 and COX-2, on disease-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcac21991897b16626f5cbb5d90c2e64
https://doi.org/10.1002/cncr.11437

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Regulation of cell growth and the expression of extracellular matrix proteins in colorectal adenocarcinoma: a fibroblast-tumor cell coculture model to study tumor-host interactions in vitro

Autor: Annalisa Siri, Stefan Berger, Antje Siegert, Carsten Denkert, Martin Köbel, Laura Borsi, Steffen Hauptmann, Stefan Ott

Publikováno v: European Journal of Cell Biology. 82:1-8

Summary The production of abundant connective tissue within malignant tumors, the so-called desmoplastic stromal reaction, is a hallmark of colorectal adenocarcinomas. This stroma is produced to a large extent by myofibroblasts and contains various a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac2fea73c4996bf34ae56653a8110e5
https://doi.org/10.1078/0171-9335-00283

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[Untitled]

Autor: Andreas Turzynski, Anja Leclere, Antje Siegert, Steffen Hauptmann, Carsten Denkert

Publikováno v: Clinical and Experimental Metastasis. 19:79-85

A lot of parallels have been described between invasion of malignant tumor cells and leukocyte movement during inflammatory responses. Concerning these similarities, we investigated the function of cytokine-suppressive anti-inflammatory drugs (CSAIDs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9337257f178e689a9f4900530aa20f82
https://doi.org/10.1023/a:1013857325012

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