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Blood-based RAS mutation testing: concordance with tissue-based RAS testing and mutational changes on progression

Autor: Jane Rogan, Sharzad Moghadam, Theodora Germetaki, M. Braun, Mark P Saunders, Antje Lukas, Eva Lenfert, Daniel L. Edelstein, Camille Nicholls, Frederick S. Jones, Richard Adams

Aim: To determine the concordance between plasma and tissue RAS mutation status in metastatic colorectal cancer patients to gauge whether blood-based testing is a viable alternative. We also evaluated the change in mutation status on progression. Mat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd86098bcb9c7183b5d6c65414b80b00
https://orca.cardiff.ac.uk/id/eprint/141030/1/fon-2020-0523.pdf

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Blood-based

Autor: Theodora, Germetaki, Camille, Nicholls, Richard A, Adams, Michael, Braun, Jane, Rogan, Sharzad, Moghadam, Eva, Lenfert, Antje, Lukas, Daniel L, Edelstein, Frederick S, Jones, Mark P, Saunders

Publikováno v: Future oncology (London, England). 16(28)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c439ec3a2cc502ba39f67d2df997bed
https://pubmed.ncbi.nlm.nih.gov/32716216

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Development of a Diagnostic Microarray Assay to Assess the Risk of Recurrence of Prostate Cancer Based on PITX2 DNA Methylation

Autor: Matthias Burger, Ina Fuhrmann, Matthias Schuster, Thomas Koenig, Robert Stoehr, Dimo Dietrich, Philipp Schatz, Glen Kristiansen, Antje Lukas, Ralf Lesche, John M. Corman, Arndt Hartmann, Gunter Weiss

Publikováno v: The Journal of Molecular Diagnostics. 12:345-353

Prostate cancer is among the most common cancers. Although it has a relatively good prognosis, 15 to 30% of men with prostate cancer experience a relapse after radical prostatectomy. Identifying patients with an aggressive tumor will therefore help t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e49999732ead3640e20cb88ec2fcefa
https://doi.org/10.2353/jmoldx.2010.090088

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Clinical applications of extended ctDNA RAS mutation determination in metastatic colorectal cancer

Publikováno v: Journal of Clinical Oncology. 35:607-607

607 Background: Tumor tissue is currently used for RAS testing in metastatic colorectal cancer (mCRC) patients, but detection of circulating tumor (ct) DNA in plasma is being actively investigated as an alternative for detection and monitoring RAS mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08f3a920b63b3a72adc4a70ef86332ec
https://doi.org/10.1200/jco.2017.35.4_suppl.607

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Performance of standardized BEAMing platform for detecting RAS mutations in the blood of metastatic colorectal cancer (mCRC) patients

Autor: Daniel L. Edelstein, Frederick S. Jones, Jessica Bien, Eva Lenfert, Antje Lukas, Jerzy Macioszek, Verena Boehm, Katharina Wichner, Kristin Stieler, Carina Ross

Publikováno v: Journal of Clinical Oncology. 34:11538-11538

11538Background: Expanded RAS testing with BEAMing has been shown to improve the identification of mCRC patients eligible for anti-EGFR therapy as evidenced by results of 1,218 patients from CRYSTA...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1af04b1a68cf1ef6e027a6bf27ec2532
https://doi.org/10.1200/jco.2016.34.15_suppl.11538

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Multicenter study using paraffin-embedded tumor tissue testing PITX2 DNA methylation as a marker for outcome prediction in tamoxifen-treated, node-negative breast cancer patients

Publikováno v: Journal of Clinical Oncology, 26(31), 5036-5042. American Society of Clinical Oncology

Purpose We recently reported DNA methylation of the paired-like homeodomain transcription factor 2 (PITX2) gene to be strongly correlated with increased risk of recurrence in node-negative, hormone receptor–positive, tamoxifen-treated breast cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5bd3da1ae8e0a28639feebd96607f4
https://www.zora.uzh.ch/id/eprint/11038/

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