Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Antje Gohla"'
Autor:
Marian Brenner, Christoph Zink, Linda Witzinger, Angelika Keller, Kerstin Hadamek, Sebastian Bothe, Martin Neuenschwander, Carmen Villmann, Jens Peter von Kries, Hermann Schindelin, Elisabeth Jeanclos, Antje Gohla
Publikováno v:
eLife, Vol 13 (2024)
Vitamin B6 deficiency has been linked to cognitive impairment in human brain disorders for decades. Still, the molecular mechanisms linking vitamin B6 to these pathologies remain poorly understood, and whether vitamin B6 supplementation improves cogn
Externí odkaz:
https://doaj.org/article/2acd61b1b59445af81ae1d6f654bae80
Autor:
Elisabeth Jeanclos, Jan Schlötzer, Kerstin Hadamek, Natalia Yuan-Chen, Mohammad Alwahsh, Robert Hollmann, Stefanie Fratz, Dilan Yesilyurt-Gerhards, Tina Frankenbach, Daria Engelmann, Angelika Keller, Alexandra Kaestner, Werner Schmitz, Martin Neuenschwander, Roland Hergenröder, Christoph Sotriffer, Jens Peter von Kries, Hermann Schindelin, Antje Gohla
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Targeting cellular glucose metabolism is a therapeutic strategy in human diseases such as autoimmunity or cancer. Here, the authors demonstrate the druggability of phosphoglycolate phosphatase, and validate an alternative approach to control glycolys
Externí odkaz:
https://doaj.org/article/fece9c1dab514555a6b20fa9b7dd7974
Autor:
Kathy Busse, Rainer Strotmann, Karl Strecker, Florian Wegner, Vasudharani Devanathan, Antje Gohla, Torsten Schöneberg, Johannes Schwarz
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92605 (2014)
BACKGROUND: RGS9-deficient mice show drug-induced dyskinesia but normal locomotor activity under unchallenged conditions. RESULTS: Genes related to Ca2+ signaling and their functions were regulated in RGS9-deficient mice. CONCLUSION: Changes in Ca2+
Externí odkaz:
https://doaj.org/article/02c8c65db1f54e15b0ea4990c1d2f0c2
Autor:
Andrea Odersky, Oleg Fedorchenko, Gunnar Knobloch, Hermann Schindelin, Anna-Karina Lamprecht, Elisabeth Jeanclos, Antje Gohla, Axel Hoffmann
Publikováno v:
FEBS Letters. 594:2099-2115
Pyridoxal 5′‐phosphate (PLP) is an essential cofactor for neurotransmitter metabolism. Pyridoxal phosphatase (PDXP) deficiency in mice increases PLP and γ‐aminobutyric acid levels in the brain, yet how PDXP is regulated is unclear. Here, we id
Autor:
Elisabeth Jeanclos, Klaus-Peter Lesch, Annette Raab, Nanda M. Verhoeven-Duif, Monique Albersen, Ruben Ramos, Antje Gohla, Christian Wilhelm, Leif Hommers
Publikováno v:
Biochimica et Biophysica Acta-Molecular Basis of Disease, 1865(1), 193-205. Elsevier Science
Biochimica et Biophysica Acta-Molecular Basis of Disease, 1865(1), 193. Elsevier
Biochimica et Biophysica Acta-Molecular Basis of Disease, 1865(1), 193. Elsevier
Pyridoxal 5'-phosphate (PLP) is an essential cofactor in the catalysis of similar to 140 different enzymatic reactions. A pharmacological elevation of cellular PLP concentrations is of interest in neuropsychiatric diseases, but whole body consequence
Autor:
Antje Gohla
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1866:153-166
Mammalian haloacid dehalogenase (HAD)-type phosphatases have evolved to dephosphorylate a wide range of small metabolites, but can also target macromolecules such as serine/threonine, tyrosine-, and histidine-phosphorylated proteins. To accomplish th
Autor:
Elisabeth Jeanclos, Hiroaki Kinoh, Sabina Quader, Kazunori Kataoka, Alevtina Cubukova, Robert Luxenhofer, Michael M. Lübtow, Antje Gohla, Clemens Schulte, Antje Appelt-Menzel, Laura Meier, Maximilian Rist, Marion Krafft, Malik Salman Haider, Oltea Sampetrean, Sabrina Oerter
Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase of the family of statins have been suggested as therapeutic options in various tumors. Atorvastatin is a statin with the potential to cross the blood-brain barrier; however, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5037f87c4a221b7d8bb65f0cc0339dc7
https://publica.fraunhofer.de/handle/publica/263209
https://publica.fraunhofer.de/handle/publica/263209
Autor:
Johann Bauersachs, Oliver J. Müller, Joerg Heineke, Kai C. Wollert, Janina K Döppner, Anna Gigina, Michaela Scherr, Hugo A. Katus, Malgorzata Szaroszyk, Andrea Grund, Badder Kattih, Mona Malek Mohammadi, Ulrich Martin, Ina Gruh, Mortimer Korf-Klingebiel, Antje Gohla, Monica Jara-Avaca, George Kensah
Publikováno v:
Cardiovascular Research. 115:71-82
Aims Chronic heart failure is becoming increasingly prevalent and is still associated with a high mortality rate. Myocardial hypertrophy and fibrosis drive cardiac remodelling and heart failure, but they are not sufficiently inhibited by current trea
Autor:
Michael M Lübtow, Sabrina Oertner, Sabina Quader, Elisabeth Jeanclos, Alevtina Cubukova, Marion Krafft, Clemens Schulte, Laura Meier, Maximilian Rist, Oltea Sampetrean, Hiroaki Kinoh, Antje Gohla, Kazunori Kataoka, Antje Appelt-Menzel, Robert Luxenhofer
Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase of the family of statins have been suggested as therapeutic options in various tumors. Atorvastatin is a statin with potential to cross the blood-brain-barrier, however, the conc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ae143ba997397025c7d92fd5414f38
https://doi.org/10.26434/chemrxiv.10067993
https://doi.org/10.26434/chemrxiv.10067993
Dissection and Explant Culture of Murine Allantois for the In Vitro Analysis of Allantoic Attachment
Publikováno v:
Journal of Visualized Experiments.
The placenta is essential for the growth and development of mammalian embryos. For this reason, numerous genetic alterations and likely also environmental insults that disturb placenta development or function can cause early pregnancy loss in mice an