Zobrazeno 1 - 10
of 248
pro vyhledávání: '"Antje, Sucker"'
Autor:
Nalini Srinivas, Lukas Peiffer, Kai Horny, Kuan Cheok Lei, Terkild B. Buus, Linda Kubat, Meng Luo, Menghong Yin, Ivelina Spassova, Antje Sucker, Farnoush Farahpour, Jan Kehrmann, Selma Ugurel, Elisabeth Livingstone, Thilo Gambichler, Niels Ødum, Jürgen C. Becker
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundMycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma (CTCL). Comprehensive analysis of MF cells in situ and ex vivo is complicated by the fact that is challenging to distinguish malignant from reactive T cells with
Externí odkaz:
https://doaj.org/article/b05b6c455d114b53a032805bb49cb832
Autor:
Johanna Matull, Jan-Malte Placke, Georg Lodde, Anne Zaremba, Jochen Utikal, Patrick Terheyden, Claudia Pföhler, Rudolf Herbst, Alexander Kreuter, Julia Welzel, Julia Kretz, Inga Möller, Antje Sucker, Annette Paschen, Elisabeth Livingstone, Lisa Zimmer, Eva Hadaschik, Selma Ugurel, Dirk Schadendorf, Carl Maximilian Thielmann, Klaus Georg Griewank
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundScreening for gene mutations has become routine clinical practice across numerous tumor entities, including melanoma. BAP1 gene mutations have been identified in various tumor types and acknowledged as a critical event in metastatic uveal m
Externí odkaz:
https://doaj.org/article/ffb5dcdffd0f4202acd393d8e273a129
Autor:
Jan‐Malte Placke, Maximilian Zahn, Hannah Zillikens, Frederik Krefting, Georg C. Lodde, Lisa Zimmer, Elisabeth Livingstone, Eva Hadaschik, Antje Sucker, Alexander Roesch, Alpaslan Tasdogan, Nalini K. Srinivas, Dirk Schadendorf, Jürgen C. Becker, Selma Ugurel
Publikováno v:
JEADV Clinical Practice, Vol 2, Iss 4, Pp 810-818 (2023)
Abstract Background Merkel cell carcinoma (MCC) is one of the deadliest skin cancers. Despite existing national guidelines, treatment of MCC patients is not as well standardized as for more common skin cancers. Objectives The study objective was to i
Externí odkaz:
https://doaj.org/article/188049c65be2447ba65d4615d59cda63
Autor:
Jan-Malte Placke, Mona Kimmig, Klaus Griewank, Rudolf Herbst, Patrick Terheyden, Jochen Utikal, Claudia Pföhler, Jens Ulrich, Alexander Kreuter, Peter Mohr, Ralf Gutzmer, Friedegund Meier, Edgar Dippel, Julia Welzel, Daniel Robert Engel, Sophia Kreft, Antje Sucker, Georg Lodde, Frederik Krefting, Ingo Stoffels, Joachim Klode, Alexander Roesch, Lisa Zimmer, Elisabeth Livingstone, Eva Hadaschik, Jürgen C. Becker, Michael Weichenthal, Alpaslan Tasdogan, Dirk Schadendorf, Selma Ugurel
Publikováno v:
EBioMedicine, Vol 96, Iss , Pp 104774- (2023)
Summary: Background: PD-1-based immune checkpoint inhibition (ICI) is the major backbone of current melanoma therapy. Tumor PD-L1 expression represents one of few biomarkers predicting ICI therapy outcome. The objective of the present study was to sy
Externí odkaz:
https://doaj.org/article/2d744a8eed3741f3b79556e7478f0af0
Autor:
Antje Sucker, Iris Helfrich, Luiza Martins Nascentes Melo, Dayana Herrera-Rios, Daniel Hinze, Stefanie Löffek, Irem Oezel, Juliane Klein, Sonia Leonardelli, Isa-Vanessa Westedt, Yahya Al-Matary, Sara Egea-Rodriguez, Alexandra Brenzel, Maja Bau, Eva Hadaschik, Florian Wirsdörfer, Niklas Uhlenbrock, Daniel Rauh, Joanna Poźniak, Florian Rambow, Jean-Christophe Marine, Maike Effern, Nicole Glodde, Jadwiga Jablonska
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 4 (2023)
Background Immune responses against tumors are subject to negative feedback regulation. Immune checkpoint inhibitors (ICIs) blocking Programmed cell death protein 1 (PD-1), a receptor expressed on T cells, or its ligand PD-L1 have significantly impro
Externí odkaz:
https://doaj.org/article/eb05894568da4d9e909a3aa7f4f8edb4
Autor:
Lea Jessica Albrecht, Anna Höwner, Klaus Griewank, Smiths S. Lueong, Nils vonNeuhoff, Peter A. Horn, Antje Sucker, Annette Paschen, Elisabeth Livingstone, Selma Ugurel, Lisa Zimmer, Susanne Horn, Jens T. Siveke, Dirk Schadendorf, Renáta Váraljai, Alexander Roesch
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 11, Pp n/a-n/a (2022)
Abstract Background Plasma‐derived tumour‐specific cell‐free nucleic acids are increasingly utilized as a minimally invasive, real‐time biomarker approach in many solid tumours. Circulating tumour DNA of melanoma‐specific mutations is curre
Externí odkaz:
https://doaj.org/article/a603443095964c8b9b8f72dc9363e7fa
Autor:
Dirk Schadendorf, Antje Sucker, Johannes Koch, Fang Zhao, Susanne Horn, Beatrice Thier, Simone Stupia, Alicia Brüggemann, Nina Schulze, Christoph Coch, Gunther Hartmann, Annette Paschen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 6 (2022)
Externí odkaz:
https://doaj.org/article/a455cc172a084acda6e1751b28b18d59
Autor:
Anne Zaremba, Rafaela Kramer, Viola De Temple, Stefanie Bertram, Martin Salzmann, Anja Gesierich, Lydia Reinhardt, Barouyr Baroudjian, Michael M. Sachse, Gunhild Mechtersheimer, Douglas B. Johnson, Alison M. Weppler, Lavinia Spain, Carmen Loquai, Milena Dudda, Claudia Pföhler, Adriana Hepner, Georgina V. Long, Alexander M. Menzies, Matteo S. Carlino, Céleste Lebbé, Tomohiro Enokida, Makoto Tahara, Paul J. Bröckelmann, Thomas Eigentler, Katharina C. Kähler, Ralf Gutzmer, Carola Berking, Selma Ugurel, Nadine Stadtler, Antje Sucker, Jürgen C. Becker, Elisabeth Livingstone, Friedegund Meier, Jessica C. Hassel, Dirk Schadendorf, Maher Hanoun, Lucie Heinzerling, Lisa Zimmer
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
IntroductionImmune checkpoint inhibitors (ICI) are increasingly being used to treat numerous cancer types. Together with improved recognition of toxicities, this has led to more frequent identification of rare immune-related adverse events (irAE), fo
Externí odkaz:
https://doaj.org/article/d10a83d504ce49babdcbd1b891ef629b
Autor:
Jan-Malte Placke, Camille Soun, Jenny Bottek, Rudolf Herbst, Patrick Terheyden, Jochen Utikal, Claudia Pföhler, Jens Ulrich, Alexander Kreuter, Christiane Pfeiffer, Peter Mohr, Ralf Gutzmer, Friedegund Meier, Edgar Dippel, Michael Weichenthal, Lisa Zimmer, Elisabeth Livingstone, Jürgen C. Becker, Georg Lodde, Antje Sucker, Klaus Griewank, Susanne Horn, Eva Hadaschik, Alexander Roesch, Dirk Schadendorf, Daniel Robert Engel, Selma Ugurel
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundPD-1-based immune checkpoint blockade (ICB) is a highly effective therapy in metastatic melanoma. However, 40-60% of patients are primarily resistant, with valid predictive biomarkers currently missing. This study investigated the digitally
Externí odkaz:
https://doaj.org/article/967680da967d4d1da0a6265a5de347ab
Autor:
Nikolaus B. Wagner, Benjamin Weide, Mirko Gries, Maike Reith, Kathrin Tarnanidis, Valerie Schuermans, Charlotte Kemper, Coretta Kehrel, Anne Funder, Ramtin Lichtenberger, Antje Sucker, Esther Herpel, Tim Holland-Letz, Dirk Schadendorf, Claus Garbe, Viktor Umansky, Jochen Utikal, Christoffer Gebhardt
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-10 (2019)
Abstract Background Predicting metastasis in melanoma patients is important for disease management and could help to identify those who might benefit from adjuvant treatment. The aim of this study was to investigate whether the tumor microenvironment
Externí odkaz:
https://doaj.org/article/bdaced2bc15445bbb4dd0a04fba39c24