Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Antje, Dickmanns"'
Autor:
Lisa-Marie Funk, Gereon Poschmann, Fabian Rabe von Pappenheim, Ashwin Chari, Kim M. Stegmann, Antje Dickmanns, Marie Wensien, Nora Eulig, Elham Paknia, Gabi Heyne, Elke Penka, Arwen R. Pearson, Carsten Berndt, Tobias Fritz, Sophia Bazzi, Jon Uranga, Ricardo A. Mata, Matthias Dobbelstein, Rolf Hilgenfeld, Ute Curth, Kai Tittmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Besides vaccines, the development of antiviral drugs targeting SARS-CoV-2 is critical for preventing future COVID outbreaks. The SARS-CoV-2 main protease (Mpro), a cysteine protease with essential functions in viral replication, has been val
Externí odkaz:
https://doaj.org/article/721e5465cdfb4b73a39d8f7ff2da8167
Autor:
Arne Zibat, Xiaoxiao Zhang, Antje Dickmanns, Kim M. Stegmann, Adrian W. Dobbelstein, Halima Alachram, Rebecca Soliwoda, Gabriela Salinas, Uwe Groß, Dirk Görlich, Maik Kschischo, Bernd Wollnik, Matthias Dobbelstein
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107786- (2023)
Summary: N4-hydroxycytidine (NHC), the active compound of the drug Molnupiravir, is incorporated into SARS-CoV-2 RNA, causing false base pairing. The desired result is an “error catastrophe,” but this bears the risk of mutated virus progeny. To a
Externí odkaz:
https://doaj.org/article/e6f4cd40f75443999577c2a955f4834d
Autor:
Kim M. Stegmann, Antje Dickmanns, Natalie Heinen, Claudia Blaurock, Tim Karrasch, Angele Breithaupt, Robert Klopfleisch, Nadja Uhlig, Valentina Eberlein, Leila Issmail, Simon T. Herrmann, Amelie Schreieck, Evelyn Peelen, Hella Kohlhof, Balal Sadeghi, Alexander Riek, John R. Speakman, Uwe Groß, Dirk Görlich, Daniel Vitt, Thorsten Müller, Thomas Grunwald, Stephanie Pfaender, Anne Balkema-Buschmann, Matthias Dobbelstein
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104293- (2022)
Summary: The nucleoside analog N4-hydroxycytidine (NHC) is the active metabolite of the prodrug molnupiravir, which has been approved for the treatment of COVID-19. SARS-CoV-2 incorporates NHC into its RNA, resulting in defective virus genomes. Likew
Externí odkaz:
https://doaj.org/article/3893fdc86a5b4569a07925c5deb2bfb2
Autor:
Kai Tittmann, Lisa-Marie Funk, Fabian Rabe von Pappenheim, Marie Wensien, Nora Eulig, Elke Penka, Kim Stegmann, Antje Dickmanns, Matthias Dobbelstein, Ricardo Mata, Jon Uranga, Sophia Bazzi, Tobias Fritz, Ashwin Chari, Elham Paknia, Gaby Heyne, Arwen Pearson, Rolf Hilgenfeld, Ute Curth, Carsten Berndt, Gereon Poschmann
Besides vaccines, the development of antiviral drugs targeting SARS-CoV-2 is critical for stopping the current COVID-19 pandemic and preventing future outbreaks. The SARS-CoV-2 main protease (Mpro), a cysteine protease with essential functions in vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c52d5429e39701bce7669e6b07b16574
https://doi.org/10.21203/rs.3.rs-2341326/v1
https://doi.org/10.21203/rs.3.rs-2341326/v1
Autor:
Matthias Dobbelstein, Antje Dickmanns, Anne Müller, Daniela Kramer, Knut Schäkel, Stephan Hailfinger, Klaus Schulze-Osthoff, Claudia Resch
Publikováno v:
J Clin Invest
Psoriasis is a frequent, inflammatory skin disease characterized by keratinocyte hyperproliferation and a disease-related infiltration of immune cells. Here, we identified a novel proinflammatory signaling pathway driven by cyclin-dependent kinase 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a0116af4b0d8578b983f9877a85a0d
https://doi.org/10.1172/jci134217
https://doi.org/10.1172/jci134217
Autor:
Lisa-Marie Funk, Gereon Poschmann, Ashwin Chari, Fabian Rabe von Pappenheim, Kim-Maren Stegmann, Antje Dickmanns, Nora Eulig, Marie Wensien, Elham Paknia, Gabi Heyne, Elke Penka, Arwen R. Pearson, Carsten Berndt, Tobias Fritz, Sophia Bazzi, Jon Uranga, Ricardo A. Mata, Matthias Dobbelstein, Rolf Hilgenfeld, Ute Curth, Kai Tittmann
Besides vaccines, the development of antiviral drugs targeting SARS-CoV-2 is critical for stopping the current COVID-19 pandemic and preventing future outbreaks. The SARS-CoV-2 main protease (Mpro), a cysteine protease with essential functions in vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c180ad7c9a84e59bc5f1117bc181f463
https://doi.org/10.1101/2022.04.18.487732
https://doi.org/10.1101/2022.04.18.487732
Autor:
Oleh Rymarenko, Kathrin Gregor, Volker C. Cordes, Jürgen Schünemann, Dirk Görlich, Christian Dienemann, Antje Dickmanns, Kim M. Stegmann, Uwe Groß, Bianka Mussil, Matthias Dobbelstein, Renate Rees, Waltraud Taxer, Jens Krull, Thomas Güttler, Philip Gunkel, M. Aksu, Ulrike Teichmann
Publikováno v:
The EMBO Journal
EMBO Journal
EMBO Journal
Monoclonal anti‐SARS‐CoV‐2 immunoglobulins represent a treatment option for COVID‐19. However, their production in mammalian cells is not scalable to meet the global demand. Single‐domain (VHH) antibodies (also called nanobodies) provide an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15d709374a21cebcda5e600711f8588
https://doi.org/10.15252/embj.2021107985
https://doi.org/10.15252/embj.2021107985
Autor:
Bernd Wollnik, Uwe Gross, Cathrin Bierwirth, Matthias Dobbelstein, Sabrina Gerber, Dirk Goerlich, Maren Sitte, Denise Schloesser, Vella Nikolova, Valentina Manzini, Antje Dickmanns, Gabriela Salinas, Kim M. Stegmann, Julia Freund, Raimond Lugert, Luisa Klemke
The search for successful therapies of infections with the coronavirus SARS-CoV-2 is ongoing. We tested inhibition of host cell nucleotide synthesis as a promising strategy to decrease the replication of SARS-CoV-2-RNA, thus diminishing the formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6382df62d9dea1ee8cda400fb086011
https://doi.org/10.1101/2020.07.18.210013
https://doi.org/10.1101/2020.07.18.210013
Autor:
Anusha, Sriraman, Antje, Dickmanns, Zeynab, Najafova, Steven A, Johnsen, Matthias, Dobbelstein
Publikováno v:
Cell Death and Disease, Vol 9, Iss 9, Pp 1-16 (2018)
Cell Death & Disease
Cell Death & Disease
The genes encoding MDM2 and CDK4 are frequently co-amplified in sarcomas, and inhibitors to both targets are approved or clinically tested for therapy. However, we show that inhibitors of MDM2 and CDK4 antagonize each other in their cytotoxicity towa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8da90cb1fa93b657dd7d6715cc94b522
http://link.springer.com/article/10.1038/s41419-018-0968-0
http://link.springer.com/article/10.1038/s41419-018-0968-0
Autor:
Uwe Groß, Maren Sitte, Dirk Görlich, Bernd Wollnik, Toni Luise Meister, Kim M. Stegmann, Luisa Klemke, Julia Freund, Sabrina Gerber, Matthias Dobbelstein, Vella Nikolova, Denise Schlösser, Stephanie Pfaender, Cathrin Bierwirth, Gabriela Salinas, Raimond Lugert, Antje Dickmanns, Valentina Manzini
Publikováno v:
Virus Research
The search for successful therapies of infections with the coronavirus SARS-CoV-2 is ongoing. We tested inhibition of host cell nucleotide synthesis as a promising strategy to decrease the replication of SARS-CoV-2-RNA, thus diminishing the formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3915bc1701cfb41e7cd3c0f25e1eb659
https://doi.org/10.1016/j.virusres.2021.198469
https://doi.org/10.1016/j.virusres.2021.198469