Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Antje, Beling"'
Autor:
Maxim Girod, Anja Geisler, Luisa Hinze, Leslie Elsner, Babette Dieringer, Antje Beling, Jens Kurreck, Henry Fechner
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5618 (2024)
FOLFOXIRI chemotherapy is a first-line therapy for advanced or metastatic colorectal cancer (CRC), yet its therapeutic efficacy remains limited. Immunostimulatory therapies like oncolytic viruses can complement chemotherapies by fostering the infiltr
Externí odkaz:
https://doaj.org/article/6555d9290d944c98a58e1101e1495938
Autor:
Fabien Thery, Lia Martina, Caroline Asselman, Yifeng Zhang, Madeleine Vessely, Heidi Repo, Koen Sedeyn, George D. Moschonas, Clara Bredow, Qi Wen Teo, Jingshu Zhang, Kevin Leandro, Denzel Eggermont, Delphine De Sutter, Katie Boucher, Tino Hochepied, Nele Festjens, Nico Callewaert, Xavier Saelens, Bart Dermaut, Klaus-Peter Knobeloch, Antje Beling, Sumana Sanyal, Lilliana Radoshevich, Sven Eyckerman, Francis Impens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
During microbial infection, proteins are modified by the ubiquitin-like protein ISG15. Here, the authors uncover RNF213 as a sensor for ISGylated proteins on the surface of lipid droplets, showing that RNF213 has antiviral properties but also directl
Externí odkaz:
https://doaj.org/article/765d12e51ea74ac084ead2b6c27e1699
Autor:
Martina Gast, Vanasa Nageswaran, Andreas W. Kuss, Ana Tzvetkova, Xiaomin Wang, Liliana H. Mochmann, Pegah Ramezani Rad, Stefan Weiss, Stefan Simm, Tanja Zeller, Henry Voelzke, Wolfgang Hoffmann, Uwe Völker, Stefan B. Felix, Marcus Dörr, Antje Beling, Carsten Skurk, David-Manuel Leistner, Bernhard H. Rauch, Tetsuro Hirose, Bettina Heidecker, Karin Klingel, Shinichi Nakagawa, Wolfram C. Poller, Filip K. Swirski, Arash Haghikia, Wolfgang Poller
Publikováno v:
Cells, Vol 11, Iss 24, p 3970 (2022)
The evolutionary conserved NEAT1-MALAT1 gene cluster generates large noncoding transcripts remaining nuclear, while tRNA-like transcripts (mascRNA, menRNA) enzymatically generated from these precursors translocate to the cytosol. Whereas functions ha
Externí odkaz:
https://doaj.org/article/ec8ff563749948efa86a683c898e23a4
Autor:
Yifeng Zhang, Fabien Thery, Nicholas C. Wu, Emma K. Luhmann, Olivier Dussurget, Mariko Foecke, Clara Bredow, Daniel Jiménez-Fernández, Kevin Leandro, Antje Beling, Klaus-Peter Knobeloch, Francis Impens, Pascale Cossart, Lilliana Radoshevich
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
ISG15 is a ubiquitin-like modifier that can be upregulated in response to bacterial infections. Here, the authors use proteomics to identify endogenous ISGylation substrates in the liver of Listeria monocytogenes infected mice and show that ISGylatio
Externí odkaz:
https://doaj.org/article/3ec566daad4b41d8b8622180c6d91133
A Conserved Cysteine Residue in Coxsackievirus B3 Protein 3A with Implication for Elevated Virulence
Autor:
Martin Voss, Sandra Pinkert, Meike Kespohl, Niclas Gimber, Karin Klingel, Jan Schmoranzer, Michael Laue, Matthias Gaida, Peter-Michael Kloetzel, Antje Beling
Publikováno v:
Viruses, Vol 14, Iss 4, p 769 (2022)
Enteroviruses (EV) are implicated in an extensive range of clinical manifestations, such as pancreatic failure, cardiovascular disease, hepatitis, and meningoencephalitis. We recently reported on the biochemical properties of the highly conserved cys
Externí odkaz:
https://doaj.org/article/9f5efb68db984bbcaa3449633c80f13b
Autor:
Nadine Althof, Carl Christoph Goetzke, Meike Kespohl, Karolin Voss, Arnd Heuser, Sandra Pinkert, Ziya Kaya, Karin Klingel, Antje Beling
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 2, Pp 200-218 (2018)
Abstract Severe heart pathology upon virus infection is closely associated with the immunological equipment of the host. Since there is no specific treatment available, current research focuses on identifying new drug targets to positively modulate p
Externí odkaz:
https://doaj.org/article/607eed355abc46dd98dc1a19e48ce185
Publikováno v:
Viruses, Vol 13, Iss 7, p 1360 (2021)
Infection by RNA viruses causes extensive cellular reorganization, including hijacking of membranes to create membranous structures termed replication organelles, which support viral RNA synthesis and virion assembly. In this study, we show that infe
Externí odkaz:
https://doaj.org/article/a673c64550d6442a9a8c1d10da95275c
Autor:
Sandra Pinkert, Meike Kespohl, Nicolas Kelm, Ziya Kaya, Arnd Heuser, Karin Klingel, Antje Beling
Publikováno v:
Viruses, Vol 13, Iss 7, p 1222 (2021)
Infection of mice with Coxsackievirus B3 (CVB3) triggers inflammation of the heart and this mouse model is commonly used to investigate underlying mechanisms and therapeutic aspects for viral myocarditis. Virus-triggered cytotoxicity and the activity
Externí odkaz:
https://doaj.org/article/4adc994e783c4863956e41ca6b0bc33d
Autor:
Janik Böhnke, Sandra Pinkert, Maria Schmidt, Hans Binder, Nicole Christin Bilz, Matthias Jung, Uta Reibetanz, Antje Beling, Dan Rujescu, Claudia Claus
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1220 (2021)
The association of members of the enterovirus family with pregnancy complications up to miscarriages is under discussion. Here, infection of two different human induced pluripotent stem cell (iPSC) lines and iPSC-derived primary germ-layer cells with
Externí odkaz:
https://doaj.org/article/fea5e4419ad94afe80b85e25e0a9d48c
Autor:
Hannah Louise Neumaier, Shelly Harel, Karin Klingel, Ziya Kaya, Arnd Heuser, Meike Kespohl, Antje Beling
Publikováno v:
Cells, Vol 9, Iss 5, p 1093 (2020)
Inhibition of proteasome function by small molecules is highly efficacious in cancer treatment. Other than non-selective proteasome inhibitors, immunoproteasome-specific inhibitors allow for specific targeting of the proteasome in immune cells and th
Externí odkaz:
https://doaj.org/article/c2891531edc74ebe8d9979c4098a2815